Results 21 to 30 of about 2,525,777 (194)

Ganoderic Acid A Ameliorates Pentylenetetrazol-Induced Epilepsy in Mice via Activating KCNQ2. [PDF]

CNS Neurosci Ther
GA‐A binds and activates KCNQ2, thereby reducing epileptic‐like EEG discharges, the loss and apoptosis of hippocampal neurons, and improving anxiety and depression‐like behavioral changes. In addition, GA‐A inhibits neuroinflammation and alleviates oxidative stress independent of activating KCNQ2.
Yao Y, Liu Z, Wang X, Bian C, Wang R, Zhang Y.   +5 more
europepmc   +2 more sources

Ganoderic Acids Alleviate Neuroinflammation by Targeting Myeloid Differentiation Factor 2 for Ischemic Stroke Therapy

Exploration
Neuroinflammation plays a critical role in cerebral ischemic injury, making it an important therapeutic target for stroke treatment. Ganoderic acids (GAs), the primary bioactive compounds isolated from Ganoderma lucidum, exhibit well‐demonstrated anti ...
Ang Ma, Yinhua Zhu, Yi Ying, Shuyuan Wang, Jingsong Zhang, Na Feng, Yazhu Quan, Guangying Shao, Dandan Liu, Shujie Zhang, Xiaoqiang Geng, Hong Zhou, Min Li, Dongmei Lin, Lianfu Wang, Guang Liang, Shaowei Li, Baoxue Yang   +17 more
doaj   +2 more sources

Current Techniques for the Cultivation of Ganoderma lucidum for the Production of Biomass, Ganoderic Acid and Polysaccharides [PDF]

Food Technology and Biotechnology, 2003
Ganoderma lucidum is a medicinal mushroom that has been used in the Orient for more than 2000 years. Due to the long time required for basidiocarp formation, attention has recently been given to the use of submerged fermentation for the production of ...
Ricardo Wagner, Guilherme Lanzi Sassaki, Maria Angela Lopes de Almeida Amazonas, Marin Berovič, David Alexander Mitchell   +4 more
doaj   +4 more sources

Ganoderic Acid A Enhances Glycometabolism in Mouse Gastrocnemius Muscle During Exercise-Induced Fatigue via AMPK/PGC-1α Pathway Activation. [PDF]

Food Sci Nutr
This study investigated the effects of GAA, an active ingredient in Ganoderma lucidum, on exercise‐induced fatigue. GAA effectively enhances exercise performance by improving endurance duration while simultaneously reducing metabolic byproducts and muscle fiber damage.
Zhu J, Peng F, Zhang L, Guo Y, Liu W, Li J, Shang S, Zhang B, Qiu T.   +8 more
europepmc   +2 more sources

Analysis of Functional Components of Kangding Ganoderma leucocontextum and Its Antioxidant and Hypoglycemic Activity in Virto

Shipin gongye ke-ji, 2023
The contents of polysaccharides, triterpenes, ganoderic acid A, ganoderic acid C1 and ganoderic acid F in Kangding Ganoderma leucocontextum were analyzed by pharmacopoeia and HPLC.
Boyu ZHU, Yongqing ZHU, Hang CHEN, Zhuoya XIANG, Jiajun ZHAO, Junlin DENG, Jian CHEN, Xing YANG, Chen XIA   +8 more
doaj   +1 more source

Ganoderic Acid A Metabolites and Their Metabolic Kinetics [PDF]

Frontiers in Pharmacology, 2017
Ganoderic acid A (GAA), a representative active triterpenoid from Ganoderma lucidum, has been reported to exhibit antinociceptive, antioxidative, cytotoxic, hepatoprotective and anticancer activities. The present study aims (1) to identify GAA metabolites, in vivo by analyzing the bile, plasma and urine after intravenous administration to rats (20 mg ...
Cao, Fang-Rui, Feng, Li, Ye, Lin-Hu, Wang, Li-Sha, Xiao, Bing-Xin, Tao, Xue, Chang, Qi   +6 more
openaire   +2 more sources

Integrated Transcriptomics and Nontargeted Metabolomics Analysis Reveal Key Metabolic Pathways in Ganoderma lucidum in Response to Ethylene

Journal of Fungi, 2022
Ganoderic acid (GA) is an important secondary metabolite of Ganoderma lucidum with a diverse array of pharmacological properties. In this study, we found that exogenous ethylene increased the production of endogenous ethylene and ganoderic acid in G ...
Li Meng, Ruyue Zhou, Jialong Lin, Qingji Wang, Panmeng Wang, Wei Wang, Li Wang, Zhuang Li   +7 more
doaj   +1 more source

Data_Sheet_1_A methyltransferase LaeA regulates ganoderic acid biosynthesis in Ganoderma lingzhi.PDF

, 2022
The methyltransferase LaeA is a global regulator involved in the biosynthesis of secondary metabolites by ascomycete fungi. However, little is known of its regulatory role in basidiomycete fungi.
Na Li (6550), Jun-Wei Xu (4053484), Qin Luo (2182514)   +2 more
core   +1 more source

Increased production of ganoderic acids by overexpression of homologous farnesyl diphosphate synthase and kinetic modeling of ganoderic acid production in Ganoderma lucidum [PDF]

Microbial Cell Factories, 2019
Ganoderic acids (GAs), derived from the medicinal mushroom Ganoderma lucidum, possess anticancer and other important pharmacological activities. To improve production of GAs, a homologous farnesyl diphosphate synthase (FPS) gene was overexpressed in G. lucidum.
Yu Fei, Na Li, De-Huai Zhang, Jun-Wei Xu
openaire   +3 more sources

Quality Difference Study of 6 Varieties of Ganoderma Lucidum with Different Origins

Frontiers in Pharmacology, 2012
The quality difference of 6 varieties Ganoderma Lucidum with different origins was investigated in this study by comparing the contents of ganoderic acid A and B, polysaccharide and triterpenoids .The contents of ganoderic acid A and B in G.lucidum were ...
Juan eLu, Jia-zhang eQin, Ping eChen, Xi eChen, Ying-Zhi eZhang, Si-jia eZhao   +5 more
doaj   +1 more source