Biosynthesis of mushroom-derived type II ganoderic acids by engineered yeast [PDF]
Nature Communications, 2022 The biosynthetic pathway of type II ganoderic acids (GAs) in Ganoderma lucidum, a traditional medicinal mushroom, is unknown. Here, the authors assemble the genome of type II GAs accumulating accession, identify CYPs involving in type II GAs biosynthesis,
Wei Yuan +6 more
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Development of a Rapid and Confirmatory Method to Identify Ganoderic Acids in Ganoderma Mushrooms [PDF]
Frontiers in Pharmacology, 2012 To examine the composition of lanostanoids in Ganoderma lucidum, we have developed a liquid chromatography-mass spectrometry (LC-MS) method by using the ganoderic acids isolated in our laboratory as reference standards.
Hao Howard Sun, Ying eQi, Lingling eZhao
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Ganoderic Acids Alleviate Neuroinflammation by Targeting Myeloid Differentiation Factor 2 for Ischemic Stroke Therapy [PDF]
ExplorationNeuroinflammation plays a critical role in cerebral ischemic injury, making it an important therapeutic target for stroke treatment. Ganoderic acids (GAs), the primary bioactive compounds isolated from Ganoderma lucidum, exhibit well‐demonstrated anti ...
Ang Ma +17 more
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Effects of Oleic Acid Addition Methods on the Metabolic Flux Distribution of Ganoderic Acids R, S and T’s Biosynthesis [PDF]
Journal of Fungi, 2022 The effects of oleic acid addition methods on the metabolic flux distribution of ganoderic acids R, S and T’s biosynthesis from Ganoderma lucidum were investigated.
Meng-Qiu Yan +9 more
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Biotransformation of triterpenoid ganoderic acids from exogenous diterpene dihydrotanshinone I in the cultures of Ganoderma sessile [PDF]
Microbial Cell Factories, 2023 Background Triterpenoids have shown a wide range of biological activities including antitumor and antiviral effects. Typically, triterpenes are synthesized through the mevalonate pathway and are extracted from natural plants and fungi.
Xinwei Wang +5 more
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Impact of Rifampin Induction on the Fermentation Production of Ganoderic Acids by Medicinal Mushroom Ganoderma lucidum [PDF]
Applied Food Biotechnology, 2016 Backgrounds and Objectives: Ganoderic acids are the most valuable secondary metabolites in Ganoderma lucidum traditional medicinal mushrooms, which have shown antitumor properties in many studies. However, application of ganoderic acids is limited due to
Fahimeh Nojoki +6 more
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The Protective Effects of Ganoderic Acids from Ganoderma lucidum Fruiting Body on Alcoholic Liver Injury and Intestinal Microflora Disturbance in Mice with Excessive Alcohol Intake [PDF]
Foods, 2022 This study aimed to investigate the protective effects of ganoderic acids (GA) from Ganoderma lucidum against liver injury and intestinal microbial disorder in mice with excessive alcohol intake.
Ying-Jia Cao +8 more
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Synthesis of Ganoderic Acids Loaded Zein-Chitosan Nanoparticles and Evaluation of Their Hepatoprotective Effect on Mice Given Excessive Alcohol [PDF]
FoodsGanoderma lucidum, used in East Asia for its health benefits, contains ganoderic acids (GA) which have various pharmacological activities but are limited by poor water solubility and low oral bioaccessibility.
Yingjia Cao +6 more
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Research Progress on the Biological Activity of Ganoderic Acids in Ganoderma lucidum over the Last Five Years [PDF]
LifeGanoderma lucidum (G. lucidum) is a traditional edible and medicinal mushroom in China. The main bioactive components in G. lucidum include triterpenoids, polysaccharides, steroids, and sterols.
Siyi Wang +4 more
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Development of a CRISPR/Cas9 Genome Editing System in Dikaryotic Ganoderma lucidum for Targeting Key CYP450 Gene Involved in Triterpenoid Synthesis [PDF]
Journal of FungiCurrently, most research on CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) gene editing in edible fungi focuses on monokaryotic strains.
Beibei Dong +8 more
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