Results 11 to 20 of about 7,010 (202)

Increased production of ganoderic acids by overexpression of homologous farnesyl diphosphate synthase and kinetic modeling of ganoderic acid production in Ganoderma lucidum [PDF]

Microbial Cell Factories, 2019
Background Ganoderic acids (GAs), derived from the medicinal mushroom Ganoderma lucidum, possess anticancer and other important pharmacological activities.
Yu Fei, Na Li, De-Huai Zhang, Jun-Wei Xu
doaj   +5 more sources

ATP deficiency triggers ganoderic acids accumulation via fatty acid β-oxidation pathway in Ganoderma lucidum [PDF]

Microbial Cell Factories
Background Ganoderic acids (GAs), recognized as significant triterpenoid bioactive components in Ganoderma lucidum, exhibit a broad spectrum of pharmacological activities, including immunomodulation, anti-cancer, and anti-aging properties.
Weidong Liu, Yin Sun, Sining Yue, Yi Kong, Qianqian Cong, Yufei Lan, Mingwen Zhao, Liang Shi   +7 more
doaj   +4 more sources

A methyltransferase LaeA regulates ganoderic acid biosynthesis in Ganoderma lingzhi

Frontiers in Microbiology, 2022
The methyltransferase LaeA is a global regulator involved in the biosynthesis of secondary metabolites by ascomycete fungi. However, little is known of its regulatory role in basidiomycete fungi.
Qin Luo, Na Li, Jun-Wei Xu
doaj   +3 more sources

Ganoderic Acids Prevent Renal Ischemia Reperfusion Injury by Inhibiting Inflammation and Apoptosis. [PDF]

Int J Mol Sci, 2021
Renal ischemia reperfusion injury (RIRI) is one of the main causes of acute kidney injury (AKI), which can lead to acute renal failure. The development of RIRI is so complicated that it involves many factors such as inflammatory response, oxidative stress and cell apoptosis.
Shao G, He J, Meng J, Ma A, Geng X, Zhang S, Qiu Z, Lin D, Li M, Zhou H, Lin S, Yang B.   +11 more
europepmc   +6 more sources

Enhanced production of individual ganoderic acids by integrating Vitreoscilla haemoglobin expression and calcium ion induction in liquid static cultures of Ganoderma lingzhi [PDF]

Microbial Biotechnology, 2019
Summary Ganoderic acids produced by Ganoderma exhibit anticancer and antimetastatic activities. A novel approach by combining Vitreoscilla haemoglobin (VHb) expression and calcium ion induction was developed to enhance ganoderic acid (GA) production in ...
Jun‐Wei Xu, Tong‐Hui Yue, Xuya Yu, Peng Zhao, Tao Li, Na Li   +5 more
doaj   +2 more sources

Enhanced ganoderic acids production by using thermotolerant Ganoderma tsugae at high-temperature liquid cultivation [PDF]

PLoS ONE
Ganoderic acids (GAs) are bioactive triterpenoids produced by Ganoderma species with demonstrated anticancer properties. While the yield of GAs in Ganoderma tsugae is typically low, heat stress has been shown to enhance its production.
Quan Ma, Yang-Meng-Jie Jing, Li-Yuan Luo, Xiao-Long He, Yue-Qin Liu   +4 more
doaj   +3 more sources

Application of Electronic tongue and HPLC in rapid determination of functional triterpenes and origins of Ganoderma lucidum [PDF]

Frontiers in Nutrition
IntroductionGanoderma lucidum is one well known functional food resource. The triterpenes, such as Ganoderic acid A and Ganoderic acid D, as well as the sensory characteristics could reflect the quality of G. lucidum.MethodsIn order to find rapid methods
Jing Tian, Jing Tian, Jinfeng Wei, Yuxin Liu, Yuxin Liu, Changqin Li, Changqin Li, Changqin Li, Changqin Li, Changyang Ma, Changyang Ma, Changyang Ma, Changyang Ma, Wenyi Kang, Wenyi Kang, Wenyi Kang, Wenyi Kang   +16 more
doaj   +2 more sources

Decoding and reprogramming of the biosynthetic networks of mushroom-derived bioactive type II ganoderic acids in yeast [PDF]

Cell Discovery
Mushroom’s specialized secondary metabolites possess important pharmacological activities, but their biosynthetic pathway elucidation is extremely challenging, not to mention reprogramming of their biosynthetic networks to target metabolites.
Qin Wang, Ye Li, Shunhan Zhang, Wei Yuan, Zeqian Du, Ting Shi, Zhao Chang, Xingye Zhai, Yinhua Lu, Meng Wang, Juan Guo, Jian-Jiang Zhong, Han Xiao   +12 more
doaj   +2 more sources

Pharmacokinetics of ganoderic acids a and f after oral administration of ling zhi preparation in healthy male volunteers. [PDF]

Evid Based Complement Alternat Med, 2012
The objectives of this paper were to evaluate the pharmacokinetics of ganoderic acids A and F after a single oral dose of the water extract of MG2-strain Ling Zhi (MG2FB-WE) and to assess the influence of food on the pharmacokinetics in 12 healthy male ...
Teekachunhatean S, Sadja S, Ampasavate C, Chiranthanut N, Rojanasthien N, Sangdee C.   +5 more
europepmc   +5 more sources

Ganoderic acid B’s influence towards the therapeutic window of trifluoperazine (TFP) [PDF]

African Health Sciences, 2015
Background: Ganoderic acid B is an important bioactive ingredient isolated from Ganoderma lucidum, and exhibits various pharmacological activities.Aims: To investigate the influence of Ganoderic acid B towards the therapeutic window of trifluoperazine ...
Guo, J, Liu, T, Liu, X, Ni, C
core   +5 more sources