Increased production of ganoderic acids by overexpression of homologous farnesyl diphosphate synthase and kinetic modeling of ganoderic acid production in Ganoderma lucidum [PDF]
Microbial Cell Factories, 2019 Background Ganoderic acids (GAs), derived from the medicinal mushroom Ganoderma lucidum, possess anticancer and other important pharmacological activities.
Yu Fei, Na Li, De-Huai Zhang, Jun-Wei Xu
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A methyltransferase LaeA regulates ganoderic acid biosynthesis in Ganoderma lingzhi
Frontiers in Microbiology, 2022 The methyltransferase LaeA is a global regulator involved in the biosynthesis of secondary metabolites by ascomycete fungi. However, little is known of its regulatory role in basidiomycete fungi.
Qin Luo, Na Li, Jun-Wei Xu
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Development of a CRISPR/Cas9 Genome Editing System in Dikaryotic Ganoderma lucidum for Targeting Key CYP450 Gene Involved in Triterpenoid Synthesis [PDF]
Journal of FungiCurrently, most research on CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) gene editing in edible fungi focuses on monokaryotic strains.
Beibei Dong +8 more
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Enhanced production of individual ganoderic acids by integrating Vitreoscilla haemoglobin expression and calcium ion induction in liquid static cultures of Ganoderma lingzhi [PDF]
Microbial Biotechnology, 2019 Summary Ganoderic acids produced by Ganoderma exhibit anticancer and antimetastatic activities. A novel approach by combining Vitreoscilla haemoglobin (VHb) expression and calcium ion induction was developed to enhance ganoderic acid (GA) production in ...
Jun‐Wei Xu +5 more
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A Triterpenoid-Enriched GLE70 Fraction From <i>Ganoderma lingzhi</i> Ameliorates Alcoholic Liver Disease via Multi-Target Regulation. [PDF]
Food Sci NutrGLE fractions were prepared from Ganoderma lingzhi using gradient ethanol elution and evaluated for their biological activities. Among the fractions, GLE70 exhibited the strongest antioxidant and hepatoprotective effects. Integrated chemical characterization, network pharmacology, molecular docking, and in vivo validation suggested that GLE70 may exert
Chen Y +7 more
europepmc +2 more sources
Enhanced ganoderic acids production by using thermotolerant Ganoderma tsugae at high-temperature liquid cultivation [PDF]
PLoS ONEGanoderic acids (GAs) are bioactive triterpenoids produced by Ganoderma species with demonstrated anticancer properties. While the yield of GAs in Ganoderma tsugae is typically low, heat stress has been shown to enhance its production.
Quan Ma +4 more
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Ganoderic Acids Prevent Renal Ischemia Reperfusion Injury by Inhibiting Inflammation and Apoptosis [PDF]
International Journal of Molecular Sciences, 2021 Xiaoqiang Geng +2 more
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ATP deficiency triggers ganoderic acids accumulation via fatty acid β-oxidation pathway in Ganoderma lucidum [PDF]
Microbial Cell FactoriesBackground Ganoderic acids (GAs), recognized as significant triterpenoid bioactive components in Ganoderma lucidum, exhibit a broad spectrum of pharmacological activities, including immunomodulation, anti-cancer, and anti-aging properties.
Weidong Liu +7 more
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Frontiers in MicrobiologyGanoderic acids (GAs) are major functional components of Ganoderma lucidum. The study aimed to breed a new G. lucidum strain with increased contents of individual GAs. Two mating-compatible monokaryotic strains, G. 260125 and G. 260124, were successfully
Jun-Wei Xu, Xu Jun-Wei
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Glycosylation of Ganoderic Acid G by Bacillus Glycosyltransferases [PDF]
International Journal of Molecular Sciences, 2021 Ganoderma lucidum is a medicinal fungus abundant in triterpenoids, its primary bioactive components. Although numerous Ganoderma triterpenoids have already been identified, rare Ganoderma triterpenoid saponins were recently discovered. To create novel Ganoderma saponins, ganoderic acid G (GAG) was selected for biotransformation using four Bacillus ...
Jiumn-Yih Wu +4 more
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