Results 21 to 30 of about 6,455 (147)

The Potential Alleviating Property Against NAFLD by <i>Ganoderma lucidum</i> With Bacteria-Enzyme Synergistic Fermentation. [PDF]

Food Sci Nutr
A bacteria‐enzyme synergistic fermentation process using Lactobacillus rhamnosus was developed to produce fermented Ganoderma lucidum broth (FBG), which significantly enriched ganoderic acid F compared to water extraction. In FFA‐induced HepG2 cells, FBG alleviated NAFLD‐related damage by reducing lipid deposition, ROS, MDA, TC, TG, and LDL‐C, while ...
Sun M, Li K, Wang Z, Dai J, Mao J, Cai M, Sha R.   +6 more
europepmc   +2 more sources

Impact of Rifampin Induction on the Fermentation Production of Ganoderic Acids by Medicinal Mushroom Ganoderma lucidum

Applied Food Biotechnology, 2016
Backgrounds and Objectives: Ganoderic acids are the most valuable secondary metabolites in Ganoderma lucidum traditional medicinal mushrooms, which have shown antitumor properties in many studies. However, application of ganoderic acids is limited due to
Fahimeh Nojoki, Ashrafalsadat Hatamian-Zarmi, Mohammad Mir-Drikvand, Bahman Ebrahimi-Hosseinzadeh, Zahra-begom Mokhtari-Hosseini, Saeed Kalantari-Dehaghi, Maryam Esmaeilifar   +6 more
doaj   +3 more sources

Development of a CRISPR/Cas9 Genome Editing System in Dikaryotic Ganoderma lucidum for Targeting Key CYP450 Gene Involved in Triterpenoid Synthesis [PDF]

Journal of Fungi
Currently, most research on CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) gene editing in edible fungi focuses on monokaryotic strains.
Beibei Dong, Yi Tan, Gen Zou, Na Feng, Linmeng Tang, Jie Feng, Yawen Zhang, Chuanhong Tang, Jingsong Zhang   +8 more
doaj   +2 more sources

A Triterpenoid-Enriched GLE70 Fraction From <i>Ganoderma lingzhi</i> Ameliorates Alcoholic Liver Disease via Multi-Target Regulation. [PDF]

Food Sci Nutr
GLE fractions were prepared from Ganoderma lingzhi using gradient ethanol elution and evaluated for their biological activities. Among the fractions, GLE70 exhibited the strongest antioxidant and hepatoprotective effects. Integrated chemical characterization, network pharmacology, molecular docking, and in vivo validation suggested that GLE70 may exert
Chen Y, Li W, Ye S, Li J, Song X, Ma Q, Chen P, Zhang B.   +7 more
europepmc   +2 more sources

Enhanced ganoderic acids production by using thermotolerant Ganoderma tsugae at high-temperature liquid cultivation [PDF]

PLoS ONE
Ganoderic acids (GAs) are bioactive triterpenoids produced by Ganoderma species with demonstrated anticancer properties. While the yield of GAs in Ganoderma tsugae is typically low, heat stress has been shown to enhance its production.
Quan Ma, Yang-Meng-Jie Jing, Li-Yuan Luo, Xiao-Long He, Yue-Qin Liu   +4 more
doaj   +3 more sources

Enhanced production of individual ganoderic acids by integrating Vitreoscilla haemoglobin expression and calcium ion induction in liquid static cultures of Ganoderma lingzhi [PDF]

Microbial Biotechnology, 2019
Summary Ganoderic acids produced by Ganoderma exhibit anticancer and antimetastatic activities. A novel approach by combining Vitreoscilla haemoglobin (VHb) expression and calcium ion induction was developed to enhance ganoderic acid (GA) production in ...
Jun‐Wei Xu, Tong‐Hui Yue, Xuya Yu, Peng Zhao, Tao Li, Na Li   +5 more
doaj   +2 more sources

Increased production of ganoderic acids by overexpression of homologous farnesyl diphosphate synthase and kinetic modeling of ganoderic acid production in Ganoderma lucidum [PDF]

Microbial Cell Factories, 2019
Background Ganoderic acids (GAs), derived from the medicinal mushroom Ganoderma lucidum, possess anticancer and other important pharmacological activities.
Yu Fei, Na Li, De-Huai Zhang, Jun-Wei Xu
doaj   +2 more sources

ATP deficiency triggers ganoderic acids accumulation via fatty acid β-oxidation pathway in Ganoderma lucidum [PDF]

Microbial Cell Factories
Background Ganoderic acids (GAs), recognized as significant triterpenoid bioactive components in Ganoderma lucidum, exhibit a broad spectrum of pharmacological activities, including immunomodulation, anti-cancer, and anti-aging properties.
Weidong Liu, Yin Sun, Sining Yue, Yi Kong, Qianqian Cong, Yufei Lan, Mingwen Zhao, Liang Shi   +7 more
doaj   +2 more sources

Improved Production and Antitumor Properties of Triterpene Acids from Submerged Culture of Ganoderma lingzhi

Molecules, 2016
Triterpene acids (TAs) are the major bioactive constituents in the medicinal fungus Ganoderma lingzhi. However, fermentative production of TAs has not been optimized for commercial use, and whether the TAs isolated from G.
Xiao-Ling Wang, Zhong-Yang Ding, Gao-Qiang Liu, Hailong Yang, Guo-Ying Zhou   +4 more
doaj   +2 more sources

Breeding a new Ganoderma lucidum strain with increased contents of individual ganoderic acids by mono–mono crossing of genetically modified monokaryons

Frontiers in Microbiology
Ganoderic acids (GAs) are major functional components of Ganoderma lucidum. The study aimed to breed a new G. lucidum strain with increased contents of individual GAs. Two mating-compatible monokaryotic strains, G. 260125 and G. 260124, were successfully
Ding-Xi Zhou, Xiang-Ming Kong, Xiong-Min Huang, Na Li, Na Feng, Jun-Wei Xu   +5 more
doaj   +3 more sources