Metabolomic Insights into the Mechanisms of Ganoderic Acid: Protection against α-Amanitin-Induced Liver Injury [PDF]
Metabolites, 2023 α-Amanitin is a representative toxin found in the Amanita genus of mushrooms, and the consumption of mushrooms containing α-Amanitin can lead to severe liver damage.
Chong Zheng +7 more
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A methyltransferase LaeA regulates ganoderic acid biosynthesis in Ganoderma lingzhi [PDF]
Frontiers in Microbiology, 2022 The methyltransferase LaeA is a global regulator involved in the biosynthesis of secondary metabolites by ascomycete fungi. However, little is known of its regulatory role in basidiomycete fungi.
Qin Luo, Na Li, Jun-Wei Xu
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Pharmacokinetic, Metabolomic, and Stability Assessment of Ganoderic Acid H Based Triterpenoid Enriched Fraction of Ganoderma lucidum P. Karst [PDF]
Metabolites, 2022 Ganoderma lucidum P. karst is an edible fungus that is used in traditional medicine and contains triterpenoids as the major phytoconstituents. Ganoderic acids are the most abundant triterpenoids that showed pharmacological activity.
Mohd Hafizur Rehman Ansari +4 more
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Ganoderic Acid A Enhances Glycometabolism in Mouse Gastrocnemius Muscle During Exercise-Induced Fatigue via AMPK/PGC-1α Pathway Activation. [PDF]
Food Sci NutrThis study investigated the effects of GAA, an active ingredient in Ganoderma lucidum, on exercise‐induced fatigue. GAA effectively enhances exercise performance by improving endurance duration while simultaneously reducing metabolic byproducts and muscle fiber damage.
Zhu J +8 more
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Putative identification of CASTOR1 as one of the targets of ganoderic acid a via thermal proteome profiling and molecular docking [PDF]
Frontiers in PharmacologyIn traditional Chinese medicine theory, aging is hypothesized to arise from severe deficiency of kidney essence, which is posited to induce “emptiness of the sea of marrow”.
Aifang Chen +4 more
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Ganoderic Acid A and Its Amide Derivatives as Potential Anti-Cancer Agents by Regulating the p53-MDM2 Pathway: Synthesis and Biological Evaluation [PDF]
Molecules, 2023 The mechanisms of action of natural products and the identification of their targets have long been a research hotspot. Ganoderic acid A (GAA) is the earliest and most abundant triterpenoids discovered in Ganoderma lucidum.
Yi Jia +4 more
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Effects of different doses of Ganoderic Acid A on nociceptive behaviour and inflammatory parameters in polyarthritic mice rheumatoid arthritis model [PDF]
Scientific ReportsThe frequency of autoimmune diseases such as rheumatoid arthritis is increasing annually. Current treatments for these diseases cause new problems due to their side effects.
Derya Guzel Erdogan +5 more
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Ganoderic Acid A Attenuates Pathological Cardiac Hypertrophy by Attenuating Inflammatory Responses [PDF]
Current Issues in Molecular BiologyPathological cardiac hypertrophy is an important risk factor for cardiovascular disease. Ganoderic acid A (GAA), the primary bioactive constituent of Ganoderma lucidum (G.
Changlin Zhen +5 more
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Multi-omics integration identifies ganoderic acid A as a TNFα inhibitor for treating sepsis-related liver injury [PDF]
Frontiers in PharmacologyGanoderic acid A (GAA), a major bioactive triterpenoid from Ganoderma lucidum, is known for its anti-inflammatory effects; however, its precise molecular targets in sepsis-related liver injury (SRLI) remain unclear.
Hong Hu +9 more
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Ganoderic acid a potentiates cisplatin’s cytotoxicity on gallbladder cancer cells by promoting DNA damage and inhibiting cell stemness [PDF]
World Journal of Surgical OncologyBackground Ganoderma acid A (GAA), a triterpenoid compound from Ganoderma lucidum, has gained attention for its anti-tumor properties. Herein, we hypothesized that GAA may enhance cisplatin’s (DDP) anticancer effect in gallbladder cancer (GBC) cells by ...
Gan Zhang +6 more
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