Ganoderic Acid A Prevented Osteoporosis by Modulating the PIK3CA/p-Akt/TWIST1 Signaling Pathway. [PDF]
Food Sci NutrOsteoporosis is a disorder of decreased bone mass, microarchitectural deterioration, and fragility fractures. Ganoderma lucidum has been reported to have a variety of pharmacological activities, including immune regulation, anti‐inflammation ...
Zhao J +6 more
europepmc +2 more sources
Establishment and Application of a Method for the Determination of Ganoderic Acid A [PDF]
Journal of Food Quality, 2020 A method for the quantitative determination of ganoderic acid A was constructed using the principle of indirect competitive enzyme-linked immunosorbent assay (ELISA), and this method was used to determine the ganoderic A contents of Ganoderma lucidum ...
Shengyun Li +5 more
doaj +2 more sources
Biotransformation of Ganoderic Acid A to 3-O-Acetyl Ganoderic Acid A by Soil-isolated Streptomyces sp. [PDF]
Fermentation, 2018 The medicinal fungus Ganoderma lucidum contains many bioactive triterpenoids, ganoderic acid A (GAA) being one of the major ones. The present study explored the microbial biotransformation of GAA, isolating 283 strains of soil actinomycetes and ...
Te-Sheng Chang +4 more
doaj +2 more sources
Pharmacokinetic, Metabolomic, and Stability Assessment of Ganoderic Acid H Based Triterpenoid Enriched Fraction of Ganoderma lucidum P. Karst [PDF]
Metabolites, 2022 Ganoderma lucidum P. karst is an edible fungus that is used in traditional medicine and contains triterpenoids as the major phytoconstituents. Ganoderic acids are the most abundant triterpenoids that showed pharmacological activity.
Mohd Hafizur Rehman Ansari +4 more
doaj +2 more sources
Ganoderic Acid A Alleviates Severe Acute Pancreatitis by Modulating Gut Homeostasis and Inhibiting TLR4-NLRP3 Signaling. [PDF]
J Agric Food ChemBackground Severe acute pancreatitis (SAP) manifests as a critical state marked by acute abdominal symptoms, often associated with intestinal barrier dysfunction, exacerbating SAP retroactively.
Zhang L +6 more
europepmc +2 more sources
Food Frontiers, Volume 6, Issue 6, Page 3108-3121, November 2025.Lipid metabolism disorders (LMDs) can cause many metabolic diseases and seriously threaten human health. It is necessary to develop safe drugs for long‐term use in LMDs patients. Ganoderma lucidum (G.
Feng Lu +7 more
semanticscholar +2 more sources
Ganoderic acid a derivative induces apoptosis of cervical cancer cells by inhibiting JNK pathway. [PDF]
Chin Herb MedObjective Ganoderic acid A can inhibit the proliferation and promotes the apoptosis of cancer cells. Surprisingly, the molecular mechanisms underlying the anti-cancer effects of ganoderic acid A still remain poorly defined.
Wang M +7 more
europepmc +2 more sources
Dual inhibitory potential of ganoderic acid A on GLUT1/3: computational and in vitro insights into targeting glucose metabolism in human lung cancer. [PDF]
RSC AdvHuman glucose transporters (GLUTs) facilitate the uptake of hexoses into cells. In cancer, the increased proliferation necessitates higher expression of GLUTs, with particular emphasis on GLUT1 and GLUT3.
Bashir MA +7 more
europepmc +2 more sources
In Vitro Anti-Glioblastoma Activity of a Novel Pt(IV)-Ganoderic Acid A Conjugate. [PDF]
Int J Mol SciGlioblastoma is the most aggressive primary malignant tumor of the central nervous system in adults, with a poor prognosis and high resistance to conventional therapies.
Gaiaschi L +7 more
europepmc +2 more sources
Ganoderic acid A alleviate psoriasis by inhibiting GSDMD-mediated pyroptosis.
Tissue and CellOBJECTIVE Psoriasis is a chronic inflammatory dermatological condition characterized by the infiltration of inflammatory cells into the dermal layer. This study aimed to elucidate the anti-inflammatory properties and underlying molecular mechanisms of ...
Chenggen Xiao +3 more
semanticscholar +3 more sources