Results 11 to 20 of about 10,669 (208)

Impact of Rifampin Induction on the Fermentation Production of Ganoderic Acids by Medicinal Mushroom Ganoderma lucidum [PDF]

Applied Food Biotechnology, 2016
Backgrounds and Objectives: Ganoderic acids are the most valuable secondary metabolites in Ganoderma lucidum traditional medicinal mushrooms, which have shown antitumor properties in many studies. However, application of ganoderic acids is limited due to
Fahimeh Nojoki, Ashrafalsadat Hatamian-Zarmi, Mohammad Mir-Drikvand, Bahman Ebrahimi-Hosseinzadeh, Zahra-begom Mokhtari-Hosseini, Saeed Kalantari-Dehaghi, Maryam Esmaeilifar   +6 more
doaj   +4 more sources

Effects of different doses of Ganoderic Acid A on nociceptive behaviour and inflammatory parameters in polyarthritic mice rheumatoid arthritis model [PDF]

Scientific Reports
The frequency of autoimmune diseases such as rheumatoid arthritis is increasing annually. Current treatments for these diseases cause new problems due to their side effects.
Derya Guzel Erdogan, Ayşenur Demır, Hüseyin Baylan, Özcan Budak, Erdem Cokluk, Pelin Tanyerı   +5 more
doaj   +2 more sources

A New Triterpenoid Glucoside from a Novel Acidic Glycosylation of Ganoderic Acid A via Recombinant Glycosyltransferase of Bacillus subtilis [PDF]

Molecules, 2019
Ganoderic acid A (GAA) is a bioactive triterpenoid isolated from the medicinal fungus Ganoderma lucidum. Our previous study showed that the Bacillus subtilis ATCC (American type culture collection) 6633 strain could biotransform GAA into compound (1 ...
Te-Sheng Chang, Chien-Min Chiang, Yu-Han Kao, Jiumn-Yih Wu, Yu-Wei Wu, Tzi-Yuan Wang   +5 more
doaj   +4 more sources

Putative identification of CASTOR1 as one of the targets of ganoderic acid a via thermal proteome profiling and molecular docking [PDF]

Frontiers in Pharmacology
In traditional Chinese medicine theory, aging is hypothesized to arise from severe deficiency of kidney essence, which is posited to induce “emptiness of the sea of marrow”.
Aifang Chen, Weishuai Xu, Yaxin Wang, Hualun Liang, Diling Chen   +4 more
doaj   +2 more sources

Multi-omics integration identifies ganoderic acid A as a TNFα inhibitor for treating sepsis-related liver injury [PDF]

Frontiers in Pharmacology
Ganoderic acid A (GAA), a major bioactive triterpenoid from Ganoderma lucidum, is known for its anti-inflammatory effects; however, its precise molecular targets in sepsis-related liver injury (SRLI) remain unclear.
Hong Hu, Zike Chen, Jinlu Han, Mengyan Chen, Yun Song, De Zhao, De Zhao, Chen Wang, Chen Wang, Min Shi   +9 more
doaj   +2 more sources

Ganoderic Acid Production via Aerial Co-cultivation of Ganoderma lucidum with Bacillus subtilis and Aspergillus niger Using Bubble Column Bioreactor [PDF]

Applied Food Biotechnology
Background and Objective: Ganoderma lucidum, with its medicinal characteristics, is one of the most beneficial fungi in traditional Asian medicine.
Soheil Kianirad, Dana Shakiba, Ashrafalsadat Hatamian, Zahra-Beagom Mokhtari-Hosseini, Hale Alvandi, Elham Ansari, Bahman Ebrahimi Hosseinzadeh   +6 more
doaj   +3 more sources

Ganoderic Acid A Prevented Osteoporosis by Modulating the PIK3CA/p-Akt/TWIST1 Signaling Pathway. [PDF]

Food Sci Nutr
ABSTRACT Osteoporosis is a disorder of decreased bone mass, microarchitectural deterioration, and fragility fractures. Ganoderma lucidum has been reported to have a variety of pharmacological activities, including immune regulation, anti‐inflammation, antioxidation, sedative hypnosis, blood sugar and lipid ...
Zhao J, Fan Y, Li H, Wang C, Fan S, Sun H, Liu M.   +6 more
europepmc   +3 more sources

In vitro inhibitory effects of ganoderic acid A on human liver cytochrome P450 enzymes. [PDF]

Pharm Biol, 2020
Context: Ganoderic acid A (GAA) is usually used to prevent cancers or other diseases, which make it likely to be used with other drugs metabolized by cytochromes P450.Objective: This study investigates the effect of GAA on eight major cytochrome P450 isoforms in human liver microsomes.Material and method: The effects of GAA (100 μM) on eight human ...
Xu S, Zhang F, Chen D, Su K, Zhang L, Jiang R.   +5 more
europepmc   +5 more sources

A novel approach to enhancing ganoderic acid production by Ganoderma lucidum using apoptosis induction. [PDF]

PLoS ONE, 2013
Ganoderma lucidum is one of most widely used herbal medicine and functional food in Asia, and ganoderic acids (GAs) are its active ingredients. Regulation of GA biosynthesis and enhancing GA production are critical to using G.
Bang-Jau You, Miin-Huey Lee, Ni Tien, Meng-Shiou Lee, Hui-Chuan Hsieh, Lin-Hsien Tseng, Yu-Lin Chung, Hong-Zin Lee   +7 more
doaj   +4 more sources

Ganoderic Acid A Attenuates LPS-Induced Neuroinflammation in BV2 Microglia by Activating Farnesoid X Receptor. [PDF]

Neurochem Res, 2021
AbstractNeuroinflammation plays an important role in the onset and progression of neurodegenerative diseases. Microglia-mediated neuroinflammation have been proved to be the main reason for causing the neurodegenerative diseases. Ganoderic acid A (GAA), isolated from Ganoderma lucidum, showed anti-inflammatory effect in metabolism diseases.
Jia Y, Zhang D, Yin H, Li H, Du J, Bao H.   +5 more
europepmc   +4 more sources