Results 21 to 30 of about 10,669 (208)

Ganoderic acid a potentiates cisplatin’s cytotoxicity on gallbladder cancer cells by promoting DNA damage and inhibiting cell stemness [PDF]

World Journal of Surgical Oncology
Background Ganoderma acid A (GAA), a triterpenoid compound from Ganoderma lucidum, has gained attention for its anti-tumor properties. Herein, we hypothesized that GAA may enhance cisplatin’s (DDP) anticancer effect in gallbladder cancer (GBC) cells by ...
Gan Zhang, Haoming Lan, Jie Wu, Xianfeng Sheng, Linsheng Huang, Meng Zhou, Jun Hu   +6 more
doaj   +2 more sources

Ganoderic Acid A-Mediated Modulation of Microglial Polarization is Involved in Depressive-Like Behaviors and Neuroinflammation in a Rat Model of Post-Stroke Depression [PDF]

Neuropsychiatric Disease and Treatment, 2021
Ling Zhang,1 Lei Zhang,2 Rubo Sui1 1Department of Neurology, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, People’s Republic of China; 2College of Nursing, Jinzhou Medical University, Jinzhou, People’s Republic of ...
Zhang L, Zhang L, Sui R
doaj   +2 more sources

Ganoderic Acid A Enhances Glycometabolism in Mouse Gastrocnemius Muscle During Exercise-Induced Fatigue via AMPK/PGC-1α Pathway Activation. [PDF]

Food Sci Nutr
This study investigated the effects of GAA, an active ingredient in Ganoderma lucidum, on exercise‐induced fatigue. GAA effectively enhances exercise performance by improving endurance duration while simultaneously reducing metabolic byproducts and muscle fiber damage.
Zhu J, Peng F, Zhang L, Guo Y, Liu W, Li J, Shang S, Zhang B, Qiu T.   +8 more
europepmc   +2 more sources

Ganoderic Acid A Metabolites and Their Metabolic Kinetics [PDF]

Frontiers in Pharmacology, 2017
Ganoderic acid A (GAA), a representative active triterpenoid from Ganoderma lucidum, has been reported to exhibit antinociceptive, antioxidative, cytotoxic, hepatoprotective and anticancer activities. The present study aims (1) to identify GAA metabolites, in vivo by analyzing the bile, plasma and urine after intravenous administration to rats (20 mg ...
Cao, Fang-Rui, Feng, Li, Ye, Lin-Hu, Wang, Li-Sha, Xiao, Bing-Xin, Tao, Xue, Chang, Qi   +6 more
openaire   +2 more sources

Analysis of Functional Components of Kangding Ganoderma leucocontextum and Its Antioxidant and Hypoglycemic Activity in Virto

Shipin gongye ke-ji, 2023
The contents of polysaccharides, triterpenes, ganoderic acid A, ganoderic acid C1 and ganoderic acid F in Kangding Ganoderma leucocontextum were analyzed by pharmacopoeia and HPLC.
Boyu ZHU, Yongqing ZHU, Hang CHEN, Zhuoya XIANG, Jiajun ZHAO, Junlin DENG, Jian CHEN, Xing YANG, Chen XIA   +8 more
doaj   +1 more source

Effects of Oleic Acid Addition Methods on the Metabolic Flux Distribution of Ganoderic Acids R, S and T’s Biosynthesis

Journal of Fungi, 2022
The effects of oleic acid addition methods on the metabolic flux distribution of ganoderic acids R, S and T’s biosynthesis from Ganoderma lucidum were investigated.
Meng-Qiu Yan, Xiao-Wei Su, Yan-Fang Liu, Chuan-Hong Tang, Qing-Jiu Tang, Shuai Zhou, Yi Tan, Li-Ping Liu, Jing-Song Zhang, Jie Feng   +9 more
doaj   +1 more source

Ganoderic acid A attenuates lipopolysaccharide-induced lung injury in mice [PDF]

Bioscience Reports, 2019
AbstractThe present study aimed to investigate the protective effects of ganoderic acid A (GAA) on lipopolysaccharide (LPS)-induced acute lung injury. In mouse model of LPS-induced acute lung injury, we found that GAA led to significantly lower lung wet-to-dry weight ratio and lung myeloperoxidase activity, and attenuated pathological damages.
Bing Wan, Yan Li, Shuangshuang Sun, Yang Yang, Yanling LV, Li Wang, Meijuan Song, Meizi Chen, Chengjiang Wu, Hangcheng Pan, Xiuwei Zhang   +10 more
openaire   +2 more sources

Methyl Ganoderic Acid DM: A Selective Potent Osteoclastogenesis Inhibitor [PDF]

The Open Bioactive Compounds Journal, 2009
Increased osteoclastic bone resorption plays a central role in the pathogenesis of many bone diseases, and osteoclast inhibitors are the most widely used treatments for these diseases. Ganoderic acid DM, the main component of Ganoderma lucidum, has been known for its medicinal effects such as anti-androgen and anti-proliferative activities.
Jie Liu, Jun Shiono, Yukiko Tsuji, Kuniyoshi Shimizu, Ryuichiro Kondo   +4 more
openaire   +1 more source

Integrated Transcriptomics and Nontargeted Metabolomics Analysis Reveal Key Metabolic Pathways in Ganoderma lucidum in Response to Ethylene

Journal of Fungi, 2022
Ganoderic acid (GA) is an important secondary metabolite of Ganoderma lucidum with a diverse array of pharmacological properties. In this study, we found that exogenous ethylene increased the production of endogenous ethylene and ganoderic acid in G ...
Li Meng, Ruyue Zhou, Jialong Lin, Qingji Wang, Panmeng Wang, Wei Wang, Li Wang, Zhuang Li   +7 more
doaj   +1 more source

The potential of Ganoderma lucidum extracts as bioactive ingredients in topical formulations, beyond its nutritional benefits [PDF]

, 2017
Ganoderma lucidum was characterized in terms of nutritional value and chemical composition. Thereafter, ethanolic Soxhlet extracts were evaluated for antioxidant, anti-inflammatory, antityrosinase, antimicrobial and cytotoxic effects, and further ...
Alves, Maria José, Barreiro, M.F., Barros, Lillian, Calhelha, Ricardo C., Ferreira, Isabel C.F.R., González-Paramás, Ana María, Heleno, Sandrina A., Taofiq, Oludemi   +7 more
core   +1 more source