Results 41 to 50 of about 886,070 (201)

Biosynthesis of mushroom-derived type II ganoderic acids by engineered yeast

Nature Communications, 2022
AbstractType II ganoderic acids (GAs) produced by the traditional medicinal mushroom Ganoderma are a group of triterpenoids with superior biological activities. However, challenges in the genetic manipulation of the native producer, low level of accumulation in the farmed mushroom, the vulnerabilities of the farming-based supply chain, and the elusive ...
Wei Yuan, Chenjian Jiang, Qin Wang, Yubo Fang, Jin Wang, Meng Wang, Han Xiao   +6 more
openaire   +3 more sources

Ganoderic Acid Production via Aerial Co-cultivation of Ganoderma lucidum with Bacillus subtilis and Aspergillus niger Using Bubble Column Bioreactor

Applied Food Biotechnology
Background and Objective: Ganoderma lucidum, with its medicinal characteristics, is one of the most beneficial fungi in traditional Asian medicine.
Soheil Kianirad, Dana Shakiba, Ashrafalsadat Hatamian, Zahra-Beagom Mokhtari-Hosseini, Hale Alvandi, Elham Ansari, Bahman Ebrahimi Hosseinzadeh   +6 more
doaj   +1 more source

Ganoderic acid A regulates CSF1R to reprogram tumor-associated macrophages for immune therapy of hepatocellular carcinoma.

International Immunopharmacology
BACKGROUND The tumor microenvironment (TME) plays a crucial role in cancer progression, with tumor-associated macrophages (TAMs) constituting the core cell population of the tumor immune microenvironment.
Jiahui Lu, Tinghuang Zhang, Chenying Jiang, Hongtao Hu, Yunxuan Fei, Yaqin Yang, Hai An, Haixin Qin, Zhihui Zhu, Yanzi Yang, S. Tian, Lili Huang, Huajun Zhao   +12 more
semanticscholar   +1 more source

Determination of ganoderic acids in triterpenoid constituents of Ganoderma tsugae

Journal of Food and Drug Analysis, 2020
Ganoderma product has the highest sale volume in the health food market in Taiwan. The most widely-used raw material is the species of G. tsuage. Nine triterpenoids were isolated from the fruiting body of G. tsugae and their structures were identified, using 1H NMR and FT-IR, as ganoderic acid A (1), B (2), C (3), D (4), E (5), C5 (6), C6 (7), G (8 ...
D.-H. Chen, W.K.-D. Chen
openaire   +1 more source

Induction of apoptosis and ganoderic acid biosynthesis by cAMP signaling in Ganoderma lucidum [PDF]

Scientific Reports, 2017
AbstractApoptosis is an essential physiological process that controls many important biological functions. However, apoptosis signaling in relation to secondary metabolite biosynthesis in plants and fungi remains a mystery. The fungusGanoderma lucidumis a popular herbal medicine worldwide, but the biosynthetic regulation of its active ingredients ...
Bang-Jau You, Ni Tien, Miin-Huey Lee, Bo-Ying Bao, Yih-Shyuan Wu, Tsung-Chi Hu, Hong-Zin Lee   +6 more
openaire   +3 more sources

Ganoderic Acid TR, a New Lanostanoid with 5α-Reductase Inhibitory Activity from the Fruiting Body of

Natural Product Communications, 2006
By means of 5α-reductase inhibitory activity-guided fractionation, a new lanostanoid, 15α-hydroxy-3-oxolanosta- 7, 9(11), 24(E)-trien-26-oic acid, named as ganoderic acid TR, was isolated from the ethanol extract of the fruiting bodies of Ganoderma ...
Jie Liu, Kuniyoshi Shimizu, Ryuichiro Kondo   +2 more
doaj   +1 more source

Exploratory Analysis of Biomarkers Predictive or Reflective of Ninjin'yoeito Efficacy in Patients With Loss of Appetite or Apathy Attributable to Dementia

Traditional &Kampo Medicine, Volume 13, Issue 2, August 2026.
ABSTRACT Aim This study explored biomarkers related to patient characteristics and the efficacy of Ninjin'yoeito (NYT), a traditional Japanese Kampo medicine, by conducting omics (metabolomic and microbiomic) analyses of plasma and stool samples obtained during a randomized controlled trial targeting anorexia and apathy in patients with dementia ...
Masashi Tamura, Taro Shindo, Katsutoshi Furukawa, Kei Suzuki, Kunihiro Konno, Shiori Ishizawa, Yasuharu Mizuhara, Takashi Matsumoto, Mitsue Nishiyama, Hitomi Kanno, Tetsuaki Arai   +10 more
wiley   +1 more source

Ganoderic Acid DM: An Alternative Agent for the Treatment of Advanced Prostate Cancer [PDF]

The Open Prostate Cancer Journal, 2010
Prostate cancer is the most commonly diagnosed cancer in men and accounts for significant morbidity and mortality in the western world. While traditional therapies are effective at clearing early stage cancer, they often fail to treat late stage metastatic disease.
Benjamin M, Johnson, Bently P, Doonan, Faisal F, Radwan, Azizul, Haque   +3 more
openaire   +2 more sources

Alcohol Extracts From Ganoderma lucidum Delay the Progress of Alzheimer’s Disease by Regulating DNA Methylation in Rodents

Frontiers in Pharmacology, 2019
Age-related changes in methylation are involved in the occurrence and development of tumors, autoimmune disease, and nervous system disorders, including Alzheimer’s disease (AD), in elderly individuals; hence, modulation of these methylation changes may ...
Guoxiao Lai, Guoxiao Lai, Yinrui Guo, Diling Chen, Xiaocui Tang, Ou Shuai, Tianqiao Yong, Dongdong Wang, Chun Xiao, Gailian Zhou, Yizhen Xie, Burton B. Yang, Burton B. Yang, Qingping Wu   +13 more
doaj   +1 more source

Effect of Methyl Jasmonate Elicitation on Triterpene Production and Evaluation of Cytotoxic Activity of Mycelial Culture Extracts of Ganoderma applanatum (Pers.) Pat.

Plants, 2023
Abiotic elicitation, a well-known strategy in mushroom biotechnology, promotes increased accumulation of secondary metabolites in mycelial cultures. The study aimed the effects of methyl jasmonate (MeJA) on the production of triterpenes in submerged ...
Katarzyna Sułkowska-Ziaja, Agnieszka Galanty, Agnieszka Szewczyk, Paweł Paśko, Katarzyna Kała, Anna Apola, Irma Podolak, Bożena Muszyńska   +7 more
doaj   +1 more source