Results 41 to 50 of about 10,014 (199)
Biosynthesis of mushroom-derived type II ganoderic acids by engineered yeast
Nature Communications, 2022 AbstractType II ganoderic acids (GAs) produced by the traditional medicinal mushroom Ganoderma are a group of triterpenoids with superior biological activities. However, challenges in the genetic manipulation of the native producer, low level of accumulation in the farmed mushroom, the vulnerabilities of the farming-based supply chain, and the elusive ...
Wei Yuan +6 more
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Journal of FungiCurrently, most research on CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) gene editing in edible fungi focuses on monokaryotic strains.
Beibei Dong +8 more
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Development of a Rapid and Confirmatory Method to Identify Ganoderic Acids in Ganoderma Mushrooms [PDF]
Frontiers in Pharmacology, 2012 To examine the composition of lanostanoids in Ganoderma lucidum, we have developed a liquid chromatography-mass spectrometry (LC-MS) method by using the ganoderic acids isolated in our laboratory as reference standards. The identity of 14 peaks in the high performance liquid chromatogram (HPLC) of G. lucidum has been confirmed.
Qi, Ying, Zhao, Lingling, Sun, Hao H.
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Induction of apoptosis and ganoderic acid biosynthesis by cAMP signaling in Ganoderma lucidum [PDF]
Scientific Reports, 2017 AbstractApoptosis is an essential physiological process that controls many important biological functions. However, apoptosis signaling in relation to secondary metabolite biosynthesis in plants and fungi remains a mystery. The fungusGanoderma lucidumis a popular herbal medicine worldwide, but the biosynthetic regulation of its active ingredients ...
Bang-Jau You +6 more
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, 2020 Fig. 4. Ganoderic acid biosynthesis in G. lucidum is influenced by the lag gene. A Systematic content analysis of ganoderic acid in the lag-silenced, WT and SiControl strains.
Shi, Liang +9 more
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Ganoderic Acid DM: An Alternative Agent for the Treatment of Advanced Prostate Cancer [PDF]
The Open Prostate Cancer Journal, 2010 Prostate cancer is the most commonly diagnosed cancer in men and accounts for significant morbidity and mortality in the western world. While traditional therapies are effective at clearing early stage cancer, they often fail to treat late stage metastatic disease.
Benjamin M, Johnson +3 more
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Plants, 2023 Abiotic elicitation, a well-known strategy in mushroom biotechnology, promotes increased accumulation of secondary metabolites in mycelial cultures. The study aimed the effects of methyl jasmonate (MeJA) on the production of triterpenes in submerged ...
Katarzyna Sułkowska-Ziaja +7 more
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, 2009 Investigations on Ganoderma lucidum fermentation suggested that the responses of the cell growth and metabolites biosynthesis to pH and dissolved oxygen tension (DOT) were different. The ganoderic acid (GA) production of 321.6 mg/L was obtained in the pH-
Zhong, Jian-Jiang +3 more
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Ganoderic Acid TR, a New Lanostanoid with 5α-Reductase Inhibitory Activity from the Fruiting Body of
Natural Product Communications, 2006 By means of 5α-reductase inhibitory activity-guided fractionation, a new lanostanoid, 15α-hydroxy-3-oxolanosta- 7, 9(11), 24(E)-trien-26-oic acid, named as ganoderic acid TR, was isolated from the ethanol extract of the fruiting bodies of Ganoderma ...
Jie Liu +2 more
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Food and Medicine Homologous Plants in Osteoporosis: A Scoping Review of Preclinical Evidence
Food Science &Nutrition, Volume 14, Issue 6, June 2026.Food and medicine homologous (FMH) plants and their bioactive compounds exhibit potential osteoprotective effects through multiple complementary mechanisms, including estrogen‐like signaling, attenuation of oxidative stress, modulation of the gut microbiota–bone axis, and regulation of autophagy.
Long Zhao +4 more
wiley +1 more source