Results 61 to 70 of about 886,070 (201)

Identification of potential neuroprotective compound from Ganoderma lucidum extract targeting microtubule affinity regulation kinase 4 involved in Alzheimer's disease through molecular dynamics simulation and MMGBSA

Aging Medicine, 2023
Objective Alzheimer's disease (AD) is one of the most prevalent neurological ailments, affecting around 50 million individuals globally. The condition is characterized by nerve cell damage due to the formation of amyloid‐beta plaques and neurofibrillary ...
Faizan Ahmad, Gagandeep Singh, Hemant Soni, Smriti Tandon   +3 more
doaj   +1 more source

Effect of Pd-Sensitization on Poisonous Chlorine Gas Detection Ability of TiO₂: Green Synthesis and Low-Temperature Operation

Sensors, 2022
Ganoderma lucidum mushroom-mediated green synthesis of nanocrystalline titanium dioxide (TiO2) is explored via a low-temperature (≤70 °C) wet chemical method. The role of Ganoderma lucidum mushroom extract in the reaction is to release the ganoderic acid
Satish Ekar, Umesh T. Nakate, Yogesh B. Khollam, Shoyebmohamad F. Shaikh, Rajaram S. Mane, Abu ul Hassan S. Rana, Marimuthu Palaniswami   +6 more
doaj   +1 more source

Ganoderic Acid A Extract Induces Apoptosis and Upregulates Autophagy-Related Genes in NALM-6 Cell Line: A Potential Therapeutic Agent for Acute Lymphoblastic Leukemia

Shiraz E Medical Journal
Background: Acute lymphoblastic leukemia (ALL) is the most common leukemia in children and is associated with a high relapse rate despite current treatments.
Hanie Shafiee, R. Fotouhi-Ardakani, Parisa Tandel, Faezeh Mortazavi, Simin Taheri, Atefeh Bahmei, Gholamhossein Tamaddon, N. Nasiri   +7 more
semanticscholar   +1 more source

A Triterpenoid‐Enriched GLE70 Fraction From Ganoderma lingzhi Ameliorates Alcoholic Liver Disease via Multi‐Target Regulation

Food Science &Nutrition, Volume 14, Issue 5, May 2026.
GLE fractions were prepared from Ganoderma lingzhi using gradient ethanol elution and evaluated for their biological activities. Among the fractions, GLE70 exhibited the strongest antioxidant and hepatoprotective effects. Integrated chemical characterization, network pharmacology, molecular docking, and in vivo validation suggested that GLE70 may exert
Yanjun Chen, Wenjia Li, Shiyi Ye, Jiaxue Li, Xiaobing Song, Qianli Ma, Ping Chen, Biying Zhang   +7 more
wiley   +1 more source

Synergistic Effect of Elicitors in Enhancement of Ganoderic Acid Production: Optimization and Gene Expression Studies

Applied Food Biotechnology, 2015
Ganoderma lucidum is one of the most well-known fungi, and has many applications in medicine. Ganoderic acid is among the valuable secondary metabolites of Ganoderma lucidum, and responsible for the inhibition of the tumor cell growth and cancer ...
Motaharehsadat Heydarian, Ashrafalsadat Hatamian-Zarmi, Ghassem Amoabediny, Fatemeh Yazdian, Ali Doryab   +4 more
doaj  

The Triterpenoid High-Performance Liquid Chromatography Analytical Profiles of the Mycelia of Ganoderma lucidum (lingzhi)

Microbiology Research, 2023
(1) Background: Ganoderic acids (GAs) are specific triterpenes of Ganoderma lucidum. The HPLC fingerprint profile of GAs of the fruiting body is well known, but their mycelial fingerprinting remains unclear.
Deng-Hai Chen, Jian-Yuan Wang, Mon-Tarng Chen, Yen-Chun Liu, Kuang-Dee Chen   +4 more
doaj   +1 more source

Protective Effect of LGG From Lophatherum Gracile Brongn. on Alcohol‐Injured HepG2 Cells and Exploration of Potential Mechanism

eFood, Volume 7, Issue 2, April 2026.
LGG was separated from L. gracile and its hepatoprotective effect was investigated. LGG significantly reduced the mortality, ROS and MDA content in alcohol‐injured liver cells. LGG up‐regulated 156 mRNAs (63 miRNAs) and down‐regulated 1529 mRNAs (35 miRNAs).
Yi‐Long Ma, Xin Guo, Zheng‐Fang Wu, Qian‐Lan Wu, Jing Li, Tian‐Le Mao, Zhi Li, Ya‐Fang Shang, Kiran Thakur, Zhao‐Jun Wei   +9 more
wiley   +1 more source

Quercetin Synergistically Inhibit EBV-Associated Gastric Carcinoma with Ganoderma lucidum Extracts

Molecules, 2019
Mycotherapy has been shown to improve the overall response rate during cancer treatment and reduce some chemotherapy-related adverse events. Ganoderma lucidum is a traditional mushroom used for pharmaceutical purposes. G.
Sora Huh, Seulki Lee, Su Jin Choi, Zhexue Wu, Jae-Han Cho, Lina Kim, Yu Su Shin, Byung Woog Kang, Jong Gwang Kim, Kwanghyeon Liu, Hyosun Cho, Hyojeung Kang   +11 more
doaj   +1 more source

When Pathways Converge: Iron, Lipid Peroxidation, and α‐Synuclein in Ferroptosis‐Driven Dopaminergic Neurodegeneration

Journal of Neurochemistry, Volume 170, Issue 4, April 2026.
Dopaminergic neurons are particularly susceptible to ferroptosis. Pacemaking activity–driven calcium (Ca2+) influx increases metabolic demand and reactive oxygen species (ROS) production, promoting iron release from aconitase. Alpha‐synuclein (α‐syn) enhances iron uptake via transferrin receptor 1 (TfR1) and exhibits ferrireductase activity, converting
Carmem L. Sperlich, Brent R. Stockwell, Marcelo Farina   +2 more
wiley   +1 more source

Establishment of the fingerprint of ganoderma lucidum spore powder and study on the anti-inflammatory activity of ganoderma lucidum spore oil

Guoji laonian yixue zazhi
[Objective] Establishment of a fingerprinting assay for Ganoderma lucidum spore powder and investigation of the effects of Ganoderma lucidum spore oil on the inflammatory factors IL-1β, IL-6, and TNF-α.
Yu Zhang, Lihui Hou, Le Wang, Yunshan Si, Hongjuan Wen, Ying Gao, Xiuhua Yu   +6 more
doaj   +1 more source