Results 81 to 90 of about 886,070 (201)

Improved ganoderic acids production in Ganoderma lucidum by wood decaying components [PDF]

open access: yesScientific Reports, 2017
AbstractGanoderma lucidumis a legendary Traditional Chinese Medicine (TCM) over a few thousands of years and one kind of its major active components are Ganoderic acids (GAs). GAs are largely produced in the mushroom primordium and fruiting body but much less in mycelium stage. However, little is known on the underlying regulatory mechanism.
Yanru Hu   +7 more
openaire   +2 more sources

Ganoderic acid and its derivatives as cholesterol synthesis inhibitors.

open access: yesChemical and Pharmaceutical Bulletin, 1989
Oxygenated lanosterol derivatives, which were isolated from Ganoderma lucidum (Polyporaceae) or their derivatives obtained by chemical conversion, were tested for their effect on cholesterol biosynthesis from 24,25-dihydrolanosterol by rat hepatic subcellular 10,000 x g supernatant fraction.
KOMODA, Yasuo   +3 more
openaire   +3 more sources

Discovery of ganoderic acid A (GAA) PROTACs as MDM2 protein degraders for the treatment of breast cancer.

open access: yesEuropean journal of medicinal chemistry
Breast cancer is one of the most common female malignant tumors, with triple-negative breast cancer (TNBC) being the most specific, highly invasive, metastatic and associated with a poor prognosis.
Yan Li   +7 more
semanticscholar   +1 more source

Multi‐Omics Analysis Reveals the Potential Preventive Mechanism of Lactobacillus salivarius Li01 Against L‐Arginine‐Induced Acute Pancreatitis in Mice

open access: yesMicrobial Biotechnology, Volume 19, Issue 1, January 2026.
This study reveals that Lactobacillus salivarius Li01 alleviates acute pancreatitis by increasing gut Paramuribaculum. This modulation of the microbiota and its steroid hormone metabolites suppresses the pancreatic TNF signaling pathway, uncovering a protective ‘gut‐metabolism‐immunity’ axis.
Jiamin Duan   +5 more
wiley   +1 more source

Systemic Effect of Ganoderma lucidum Filtrate on Septoria Leaf Spot and Pycnidia Formation by Septoria lycopersici

open access: yesJournal of Phytopathology, Volume 174, Issue 1, January/February 2026.
ABSTRACT This study aimed to evaluate the potential of the mycelial growth filtrate (MGF) from Ganoderma lucidum in providing systemic protection to tomato plants against Septoria lycopersici‐induced leaf spot and inhibiting the production of reproductive structures by the phytopathogen. In greenhouse experiments, foliar application of MGF at 40% (v/v)
Mycheli P. Cruz   +3 more
wiley   +1 more source

Interaction of ganoderic acid on HIV related target: molecular docking studies [PDF]

open access: yesBioinformation, 2011
Trouver le remède ultime contre le VIH reste une tâche difficile depuis des décennies. Divers composés actifs ont été testés contre divers composants du virus dans le but d'arrêter le développement du virus chez l'hôte infecté. L'idée de trouver un remède à partir de composés naturels pharmacologiquement actifs connus est intrigante et pratique.
Rahmad Akbar, Wai Keat Yam
openaire   +2 more sources

Medicinal Plants and Lead Phytomolecules as Immunomodulators: An Updated Review

open access: yesBioMed Research International, Volume 2026, Issue 1, 2026.
All therapeutic interventions aimed at modulating the immune response to pathogens, self‐antigens, carcinogens, or xenogeneic antigens are referred to as immunomodulation, which either prevents hyperactivation or restores the appropriate response of the immune system.
Gurdeep Singh   +3 more
wiley   +1 more source

Phytofabricated Silver Nanoparticles From Vaccinium arctostaphylos L.: Anticancer Activity Against Breast Cancer Cells via Apoptosis Induction and Growth Suppression

open access: yesFood Science &Nutrition, Volume 13, Issue 11, November 2025.
This study demonstrates that phytofabricated silver nanoparticles (VACAgNPs) from Vaccinium arctostaphylos L. exhibit significant anticancer activity against breast cancer cells, inducing apoptosis and suppressing growth in both hormone‐responsive (MCF‐7) and triple‐negative (4T1, MDA‐MB‐231) subtypes. The nanoparticles enhanced reactive oxygen species
Nazila Soleimani   +3 more
wiley   +1 more source

Sustainable Natural Product Glycosylation: A Critical Evaluation of Biocatalytic and Chemical Approaches

open access: yesChemSusChem, Volume 18, Issue 20, October 23, 2025.
Developing a process to produce glycosylated natural products involves many decisions, and given the current climate crisis, the environmental impact of the various processes must be a major consideration. This review provides an overview of the various processes and a framework for which metrics should be quantified to select processes that are both ...
Felipe Mejia‐Otalvaro   +3 more
wiley   +1 more source

Ganoderic Acid A Suppresses Androgen-independent Cell Growth via the AKT/GSK-3β/β-catenin Signaling Pathway

open access: yesPharmacognosy Magazine
Objectives The primary aim of this study is to investigate the specific effects and mechanisms of ganoderic acid A (GAA) on castration-resistant prostate cancer (CRPC).
Q. Lyu   +5 more
semanticscholar   +1 more source

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