Results 71 to 80 of about 886,070 (201)

High Oxygen Treatments Enhance the Contents of Phenolic Compound and Ganoderic Acid, and the Antioxidant and DNA Damage Protective Activities of Ganoderma lingzhi Fruiting Body

Frontiers in Microbiology, 2019
Ganoderma lingzhi is a famous medicinal mushroom used as Chinese medicine or functional food and has been accepted across the globe. It is important to enhance the contents of bioactive compounds, which in turn improves the quality and biological ...
Qingying Dong, Yueyue Li, Gaoqiang Liu, Zhiwei Zhang, Huabin Zhou, Hailong Yang   +5 more
doaj   +1 more source

A novel approach to enhancing ganoderic acid production by Ganoderma lucidum using apoptosis induction. [PDF]

PLoS ONE, 2013
Ganoderma lucidum is one of most widely used herbal medicine and functional food in Asia, and ganoderic acids (GAs) are its active ingredients. Regulation of GA biosynthesis and enhancing GA production are critical to using G.
Bang-Jau You, Miin-Huey Lee, Ni Tien, Meng-Shiou Lee, Hui-Chuan Hsieh, Lin-Hsien Tseng, Yu-Lin Chung, Hong-Zin Lee   +7 more
doaj   +1 more source

Ethanol Extract From Ganoderma atrum Alleviates Obesity Through Modulating Gut Microbiota and Metabolism

Food Frontiers, Volume 7, Issue 2, March 2026.
EEG potentially exerts anti‐obesity effects by reducing the abundance of Lactobacillus, which subsequently elevates the levels of conjugated bile acids. ABSTRACT Obesity is a serious public health challenge, underscoring the importance of developing natural and effective interventions.
Qiuyue Fang, Chenqing Xu, Siying Wu, Steve W. Cui, Shaoping Nie   +4 more
wiley   +1 more source

Influence of cultivation substrate on antioxidant activities and triterpenoid profiles of the fruiting body of Ganoderma lucidum

Frontiers in Nutrition
IntroductionThe fruiting body of Ganoderma lucidum has been believed to possess a wide range of therapeutic effects. There are two main methods for artificial cultivation of G.
Gelian Luo, Zhibin Pan, Zhibin Liu, Weiqing Cheng, Tingting Yu   +4 more
doaj   +1 more source

Improved Production and Antitumor Properties of Triterpene Acids from Submerged Culture of Ganoderma lingzhi

Molecules, 2016
Triterpene acids (TAs) are the major bioactive constituents in the medicinal fungus Ganoderma lingzhi. However, fermentative production of TAs has not been optimized for commercial use, and whether the TAs isolated from G.
Xiao-Ling Wang, Zhong-Yang Ding, Gao-Qiang Liu, Hailong Yang, Guo-Ying Zhou   +4 more
doaj   +1 more source

Aging‐Derived Alterations in Genomic, Immune, and Metabolic Networks: Implications for Cancer Development and Therapy

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ageing acts as a double‐edged sword in cancer. In the elderly, open chromatin, immunosenescence, and chronic inflammation drive SASP (IL‐6, MMPs), MDSC accumulation and T‐cell suppression, fostering tumor‐promoting microenvironments and limited therapeutic benefit.
Qi Wang, Xue Sun, Xinhao Han, Xingda Zhang, Wenzheng Wang, Hongbin Wang, He Ren, Lina Gu   +7 more
wiley   +1 more source

Genetic engineering ofGanoderma lucidumfor the efficient production of ganoderic acids [PDF]

Bioengineered, 2015
Ganoderma lucidum is a well-known traditional medicinal mushroom that produces ganoderic acids with numerous interesting bioactivities. Genetic engineering is an efficient approach to improve ganoderic acid biosynthesis. However, reliable genetic transformation methods and appropriate genetic manipulation strategies remain underdeveloped and thus ...
Jun-Wei, Xu, Jian-Jiang, Zhong
openaire   +2 more sources

Impact of Rifampin Induction on the Fermentation Production of Ganoderic Acids by Medicinal Mushroom Ganoderma lucidum

Applied Food Biotechnology, 2016
Backgrounds and Objectives: Ganoderic acids are the most valuable secondary metabolites in Ganoderma lucidum traditional medicinal mushrooms, which have shown antitumor properties in many studies. However, application of ganoderic acids is limited due to
Fahimeh Nojoki, Ashrafalsadat Hatamian-Zarmi, Mohammad Mir-Drikvand, Bahman Ebrahimi-Hosseinzadeh, Zahra-begom Mokhtari-Hosseini, Saeed Kalantari-Dehaghi, Maryam Esmaeilifar   +6 more
doaj  

A New Triterpenoid Glucoside from a Novel Acidic Glycosylation of Ganoderic Acid A via Recombinant Glycosyltransferase of Bacillus subtilis

Molecules, 2019
Ganoderic acid A (GAA) is a bioactive triterpenoid isolated from the medicinal fungus Ganoderma lucidum. Our previous study showed that the Bacillus subtilis ATCC (American type culture collection) 6633 strain could biotransform GAA into compound (1 ...
Te-Sheng Chang, Chien-Min Chiang, Yu-Han Kao, Jiumn-Yih Wu, Yu-Wei Wu, Tzi-Yuan Wang   +5 more
doaj   +1 more source

Ganoderic Acids Alleviate Neuroinflammation by Targeting Myeloid Differentiation Factor 2 for Ischemic Stroke Therapy

Exploration, Volume 6, Issue 1, February 2026.
Ganoderic acids confer neuroprotection in ischemic stroke by directly targeting MD2, thereby blocking MD2/TLR4 complex formation and downstream MAPK and NF‐κB activation. This suppresses microglia‐driven neuroinflammation and mitigates cerebral ischemic injury.
Ang Ma, Yinhua Zhu, Yi Ying, Shuyuan Wang, Jingsong Zhang, Na Feng, Yazhu Quan, Guangying Shao, Dandan Liu, Shujie Zhang, Xiaoqiang Geng, Hong Zhou, Min Li, Dongmei Lin, Lianfu Wang, Guang Liang, Shaowei Li, Baoxue Yang   +17 more
wiley   +1 more source