Results 51 to 60 of about 10,014 (199)

Alcohol Extracts From Ganoderma lucidum Delay the Progress of Alzheimer’s Disease by Regulating DNA Methylation in Rodents

Frontiers in Pharmacology, 2019
Age-related changes in methylation are involved in the occurrence and development of tumors, autoimmune disease, and nervous system disorders, including Alzheimer’s disease (AD), in elderly individuals; hence, modulation of these methylation changes may ...
Guoxiao Lai, Guoxiao Lai, Yinrui Guo, Diling Chen, Xiaocui Tang, Ou Shuai, Tianqiao Yong, Dongdong Wang, Chun Xiao, Gailian Zhou, Yizhen Xie, Burton B. Yang, Burton B. Yang, Qingping Wu   +13 more
doaj   +1 more source

The Potential Alleviating Property Against NAFLD by Ganoderma lucidum With Bacteria‐Enzyme Synergistic Fermentation

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
A bacteria‐enzyme synergistic fermentation process using Lactobacillus rhamnosus was developed to produce fermented Ganoderma lucidum broth (FBG), which significantly enriched ganoderic acid F compared to water extraction. In FFA‐induced HepG2 cells, FBG alleviated NAFLD‐related damage by reducing lipid deposition, ROS, MDA, TC, TG, and LDL‐C, while ...
Manhui Sun, Kecheng Li, Zhenzhen Wang, Jing Dai, Jianwei Mao, Min Cai, Ruyi Sha   +6 more
wiley   +1 more source

Target identification of HIV related ganoderic acids using molecular docking / Rahmad Akbar [PDF]

, 2011
Four Ganoderic acids (á, B, C1 H) were studied using molecular docking approach. Both reverse molecular docking and molecular docking were combined to elucidate suitable target(s) for these Ganoderic acids. Outcomes from molecular docking were compared
Akbar, Rahmad
core  

Identification of potential neuroprotective compound from Ganoderma lucidum extract targeting microtubule affinity regulation kinase 4 involved in Alzheimer's disease through molecular dynamics simulation and MMGBSA

Aging Medicine, 2023
Objective Alzheimer's disease (AD) is one of the most prevalent neurological ailments, affecting around 50 million individuals globally. The condition is characterized by nerve cell damage due to the formation of amyloid‐beta plaques and neurofibrillary ...
Faizan Ahmad, Gagandeep Singh, Hemant Soni, Smriti Tandon   +3 more
doaj   +1 more source

Target specific inhibition of West Nile virus envelope glycoprotein and methyltransferase using phytocompounds: an in silico strategy leveraging molecular docking and dynamics simulation

Frontiers in Microbiology, 2023
Mosquitoes are the primary vector for West Nile virus, a flavivirus. The virus’s ability to infiltrate and establish itself in increasing numbers of nations has made it a persistent threat to public health worldwide.
Shopnil Akash, Imren Bayıl, Md. Anisur Rahman, Nobendu Mukerjee, Nobendu Mukerjee, Swastika Maitra, Md. Rezaul Islam, Sanchaita Rajkhowa, Arabinda Ghosh, Sami A. Al-Hussain, Magdi E. A. Zaki, Vikash Jaiswal, Sanjit Sah, Sanjit Sah, Joshuan J. Barboza, Ranjit Sah, Ranjit Sah, Ranjit Sah   +17 more
doaj   +1 more source

Comprehensive Evaluation of Fructus Tsaoko, Seeds of Tsaoko Fructus and Ginger Made Seeds of Tsaoko Fructus Based on Drug‐Like Compounds and Aroma Analysis

Food Science &Nutrition, Volume 14, Issue 5, May 2026.
This study mainly consists of two parts. First, after screening for drug‐like metabolites via LC–MS and GC–MS, a comprehensive evaluation model was established using a principal component analysis‐based weighted scoring method, by which the drug‐likeness ranking of three samples was determined.
Han Chen, Meiquan Yang, Weize Yang, Mingju Qi, Zongliang Xu, Tianmei Yang, Jinyu Zhang   +6 more
wiley   +1 more source

The Triterpenoid High-Performance Liquid Chromatography Analytical Profiles of the Mycelia of Ganoderma lucidum (lingzhi)

Microbiology Research, 2023
(1) Background: Ganoderic acids (GAs) are specific triterpenes of Ganoderma lucidum. The HPLC fingerprint profile of GAs of the fruiting body is well known, but their mycelial fingerprinting remains unclear.
Deng-Hai Chen, Jian-Yuan Wang, Mon-Tarng Chen, Yen-Chun Liu, Kuang-Dee Chen   +4 more
doaj   +1 more source

A Triterpenoid‐Enriched GLE70 Fraction From Ganoderma lingzhi Ameliorates Alcoholic Liver Disease via Multi‐Target Regulation

Food Science &Nutrition, Volume 14, Issue 5, May 2026.
GLE fractions were prepared from Ganoderma lingzhi using gradient ethanol elution and evaluated for their biological activities. Among the fractions, GLE70 exhibited the strongest antioxidant and hepatoprotective effects. Integrated chemical characterization, network pharmacology, molecular docking, and in vivo validation suggested that GLE70 may exert
Yanjun Chen, Wenjia Li, Shiyi Ye, Jiaxue Li, Xiaobing Song, Qianli Ma, Ping Chen, Biying Zhang   +7 more
wiley   +1 more source

Effect of Pd-Sensitization on Poisonous Chlorine Gas Detection Ability of TiO₂: Green Synthesis and Low-Temperature Operation

Sensors, 2022
Ganoderma lucidum mushroom-mediated green synthesis of nanocrystalline titanium dioxide (TiO2) is explored via a low-temperature (≤70 °C) wet chemical method. The role of Ganoderma lucidum mushroom extract in the reaction is to release the ganoderic acid
Satish Ekar, Umesh T. Nakate, Yogesh B. Khollam, Shoyebmohamad F. Shaikh, Rajaram S. Mane, Abu ul Hassan S. Rana, Marimuthu Palaniswami   +6 more
doaj   +1 more source

Protective Effect of LGG From Lophatherum Gracile Brongn. on Alcohol‐Injured HepG2 Cells and Exploration of Potential Mechanism

eFood, Volume 7, Issue 2, April 2026.
LGG was separated from L. gracile and its hepatoprotective effect was investigated. LGG significantly reduced the mortality, ROS and MDA content in alcohol‐injured liver cells. LGG up‐regulated 156 mRNAs (63 miRNAs) and down‐regulated 1529 mRNAs (35 miRNAs).
Yi‐Long Ma, Xin Guo, Zheng‐Fang Wu, Qian‐Lan Wu, Jing Li, Tian‐Le Mao, Zhi Li, Ya‐Fang Shang, Kiran Thakur, Zhao‐Jun Wei   +9 more
wiley   +1 more source