Results 51 to 60 of about 178,028 (260)

Optimizing Intersection Design: Insights From Older Drivers’ Physiological Responses and Gap Acceptance Behavior at Signalized Left Turns

IEEE Access
Aging populations pose significant challenges for transportation safety at complex intersections. This study investigated gap acceptance behavior of older drivers at left-turn signalized permissive intersections using a driving simulator with 40 ...
Sneha Srinivasan, Amandeep Singh, Hyowon Lee, Shene Abdalla, Apurva Narayan, Siby Samuel   +5 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Analysis of Pedestrian Gap Acceptance and Crossing Decision in Kuala Lumpur

MATEC Web of Conferences, 2017
Pedestrians are most vulnerable of all road users. This research aims to investigate and model pedestrian road crossing behaviour at crossing facilities. In particular, they have two aspects of pedestrians crossing behaviour are examined, namely the size
Mohamad Nor Siti Naquiyah, David Daniel Basil, Hamidun Rizati, Al Bargi Walid A, Rohani Munzilah Md, Prasetijo Joewono, Aman Mohamad Yusri, Ambak Kamarudin   +7 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

PENGARUH GAP ACCEPTANCE TERHADAP PROBABILITAS MENYEBERANG JALAN IMPACT OF GAP ACCEPTANCE TO PROBABILITY OF PEDESTRIAN CROSSING

Jurnal Penelitian Transportasi Darat, 2019
Pesatnya pertumbuhan lalu lintas saat ini khususnya kendaraan roda dua, menyebabkan minimnya pergerakan lalu lintas non-motorized seperti pengguna sepeda serta pejalan kaki. Tingginya aktivitas lalu lintas motorized menyebabkan sulitnya seseorang mendapatkan kesempatan (gap) untuk menyeberang jalan.
openaire   +2 more sources

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

Mind the gap: A comparative study of low-car policy acceptance

European Transport Studies
The introduction or even consideration of low-car interventions may spark a heated debate amongst residents as well as between local authorities and residents.
Anastasia Roukouni, Oded Cats
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source