Results 61 to 70 of about 178,028 (260)

Pedestrian gap acceptance behavior at unsignalized mid-block crossing under mixed traffic conditions

IATSS Research
In Thailand, 68 % of pedestrian crashes on national highways in 2021 occurred when they were crossing the road. Pedestrians may encounter difficulties when deciding on the minimum safe gap to cross the road under diverse conditions, especially when the ...
Satanan Piyalungka, Kunnawee Kanitpong, Ampol Karoonsoontawong   +2 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Identifying contextual barriers and facilitators in implementing non-specialist interventions for mental health in Sri Lanka: A qualitative study with mental health workers and community members

Cambridge Prisms: Global Mental Health
Non-specialist mental health interventions serve as a potential solution to reduce the mental healthcare gap in low- and middle-income countries, such as Sri Lanka.
Kalpani Wijekoon Wijekoon Mudiyanselage, Frederike Jörg, Murukkuvadura Sajani Dilhara Mendis, Daniela C. Fuhr, Heide Busse   +4 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Study of Driver Gap Acceptance Behavior at Merging Area in Baghdad City

Iraqi Journal of Civil Engineering, 2007
This paper describes traffic behavior at merging (on-ramp) areas in Baghdad city. The objective is to predict acceptable and critical gaps necessary for completing the merging process based on observed traffic data collected from two selected sites.
Mehdi I. AL-Kubaisi
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Cuteness vs. Usefulness: A Dual Perspective on Service Robot Acceptance in the Travel Industry

Journal of Theoretical and Applied Electronic Commerce Research
The integration of service robots in the travel and hospitality industry is rapidly transforming customer interactions, offering both operational efficiencies and novel guest experiences.
José Maeiro, Álvaro Dias, Leandro Pereira   +2 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source