Results 41 to 50 of about 5,353,010 (253)

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Development of sample clean up methods for the analysis of Mycobacterium tuberculosis methyl mycocerosate biomarkers in sputum extracts by gas chromatography-mass spectrometry. [PDF]

, 2015
A proof of principle gas chromatography-mass spectrometry method is presented, in combination with clean up assays, aiming to improve the analysis of methyl mycocerosate tuberculosis biomarkers from sputum.
O'Sullivan, Denise M., Minnikin, David E, Mutetwa, Reggie, Lee, Oona Y.-C, O'Sullivan, Denise M, Minnikin, David E., McNerney, Ruth, Morgan, Geraint, Turner, Nicholas W, Lee, Oona Y.-C., Corbett, Liz E., Morgan, Geraint H, Corbett, Liz E, Lee, Oona Y-C, Nicoara, Simona C., Turner, Nicholas W., Morgan, Geraint H., Nicoara, Simona C   +17 more
core   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

The Recognition Chemicals in Fingerprints by Gas Chromatography/Mass Spectrometry [PDF]

Research on Addiction, 2014
Objective: It has been greatly attempted to learn more about chemical information on finger prints using new vehicular technique use for the detection of a variety of substances, including narcotic drugs and medicines, as well using nano particles bound ...
M Rezaei, M Gholami
doaj   +1 more source

Gas-liquid chromatography-mass spectrometry of synthetic ceramides containing phytosphingosine

Journal of Lipid Research, 1970
Ceramides containing phytosphingosine as base and one of the fatty acids 16:0, 18:0, 20:0, 22:0, 23:0, and 24:0, were prepared by direct coupling in the presence of a mixed carbodiimide. The ceramides were analyzed as the 1,3,4-tri-O-trimethylsilyl ether
Sven Hammarström
doaj   +1 more source

Mechanistic Insights into Alzheimer’s Disease Unveiled through the Investigation of Disturbances in Central Metabolites and Metabolic Pathways

Biomedicines, 2021
Hydrophilic metabolites are closely involved in multiple primary metabolic pathways and, consequently, play an essential role in the onset and progression of multifactorial human disorders, such as Alzheimer’s disease.
Raúl González-Domínguez, Álvaro González-Domínguez, Ana Sayago, Juan Diego González-Sanz, Alfonso María Lechuga-Sancho, Ángeles Fernández-Recamales   +5 more
doaj   +1 more source

The Analysis of Recreational Drugs in Biological Specimens Using Liquid Chromatography Mass Spectrometry [PDF]

, 2008
In the last few years, the prevalence of legal party pills in New Zealand has risen dramatically. These pills contain new piperazine designer drugs, two of the more common being 1-benzylpiperazine (BZP) and m-trifluoromethylphenylpiperazine (TFMPP). This
Lucas, Natasha
core  

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Data on the optimization of a GC–MS procedure for the determination of total plasma myo-inositol

Data in Brief, 2016
Myo-inositol (MI) is one of the stereoisomers of hexahydroxycyclohexane, which plays an important role in intracellular signal pathway. Derivatization is an indispensable step in both external and internal standard method during the chromatography-mass ...
Jin Guo, Yingfei Shi, Chengbao Xu, Rugang Zhong, Feng Zhang, Bo Niu, Jianhua Wang, Ting Zhang   +7 more
doaj   +1 more source

An application of data mining to fruit and vegetable sample identification using Gas Chromatography-Mass Spectrometry [PDF]

, 2012
One of the uses of Gas Chromatography-Mass Spectrometry (GC-MS) is in the detection of pesticide residues in fruit and vegetables. In a high throughput laboratory there is the potential for sample swaps or mislabelling, as once a sample has been pre ...
Holmes, Geoffrey, Reutemann, Peter, Fletcher, Dale   +2 more
core   +1 more source