Results 81 to 90 of about 85,133 (302)

Canagliflozin Alleviates Diabetic Glomerular Endothelial Injury via Melibiose in a Microbiota‐Dependent Manner

Advanced Science, EarlyView.
Canagliflozin treatment reshapes the gut microbiota in DKD and elevates levels of melibiose, a metabolite derived from Roseburia intestinalis. Melibiose directly binds to and enhances the enzymatic activity of glyoxalase 1, leading to decreased methylglyoxal accumulation.
Wei Zhang, Yi Song, Changkun Li, Yuanyuan Luo, Mingwei Shao, Feng Guo, Fangyi Wei, Xunjie Fan, Wenwen Guo, Fengmei Xu, Yanhong Sang, Dongming Zhang, Yanhong Zhou, Lianwei Wang, Zhiqiang Kang, Yingjun Yang, Chunhua Song, Yanxia Liu, Xiaojun Ma, Jiao Wang, Chong Li, Shengnan Ma, Lin Zhao, Zhi Qin, Guolan Xing, Qiubo Zhao, Jun Li, Shumin Song, Dan Zhao, Ting Huang, Qingzhu Wang, Yanyan Zhao, Guijun Qin   +32 more
wiley   +1 more source

Comparative Analysis of Single-stage and Two-stage Fermentation Systems under Various Process Conditions

BioResources, 2016
A comparative study of single-stage fermentation (wet or dry) and two-stage (wet-dry and dry-wet) fermentation systems was carried out under medium temperature conditions. The effect of the length of the first wet or dry fermentation stage (5-, 10-, 15-,
Jing Du, Yuting Qian, Haoli Qu, Yonglan Xi, Hongying Huang, Hongmei Jin, Yueding Xu, Xiwu Lü, Zhizhou Chang   +8 more
doaj   +1 more source

Dos and don’ts for scaling up gas fermentations

Current Opinion in Biotechnology
Gas fermentation processes (using CO2, CO, H2, CH4) have gained significant research and commercial interest in the last years due to their potential for carbon capture and sequestration. The small economic margins of these processes necessitate the use of large-volume bioreactors. For cost-effective gas delivery, we advise using pneumatically agitated
Lars Puiman, Carolin Bokelmann, Sean D Simpson, Alfred M Spormann, Ralf Takors   +4 more
openaire   +4 more sources

Nanocellulose Alleviates Intrahepatic Cholestasis of Pregnancy via Gut Microbiota‐Mediated Bile Acid Homeostasis

Advanced Science, EarlyView.
Nanocellulose, derived from microcrystalline cellulose (MCC) through sulfuric acid hydrolysis or mechanical grinding to produce CNC or CNF, was tested in a rat ICP model. Particularly, CNF improved gut microbiota composition, reduced secondary bile acid metabolism, and restored bile acid homeostasis through modulation of the gut–liver axis.
Muhua Yu, Hongjie Dai, Xiaocui Zhong, Qibin Li, Hui Yuan, Yang Yang, Daiyong Huang, Lei Zhang, Rui Ran, Tian He, Yuanzhi Huang, Silas Villas‐Boas, Sergey Tumanov, Richard D. Cannon, Boris Novakovic, Richard Saffery, Yuhao Zhang, Xiaojing Dong, Ting‐Li Han   +18 more
wiley   +1 more source

Scaling-up vaccine production: implementation aspects of a biomass growth observer and controller [PDF]

, 2009
This study considers two aspects of the implementation of a biomass growth observer and specific growth rate controller in scale-up from small- to pilot-scale bioreactors towards a feasible bulk production process for whole-cell vaccine against whooping ...
IJssel, J., van den, Straten, G., van, van den IJssel, J., Boxtel, A.J.B., van, Pol, L.A., van der, Soons, Z.I.T.A., van der Pol, L.A., van Boxtel, A.J.B., van Straten, G.   +8 more
core   +1 more source

Low electric current in a bioelectrochemical system facilitates ethanol production from CO using CO-enriched mixed culture

Frontiers in Microbiology
Fossil resources must be replaced by renewable resources in production systems to mitigate green-house gas emissions and combat climate change. Electro-fermentation utilizes a bioelectrochemical system (BES) to valorize industrial and municipal waste ...
Chaeho Im, Minsoo Kim, Jung Rae Kim, Kaspar Valgepea, Oskar Modin, Yvonne Nygård, Yvonne Nygård, Carl Johan Franzén   +7 more
doaj   +1 more source

Advanced Routes of Biological and Bio-electrocatalytic Carbon Dioxide (CO2) Mitigation Toward Carbon Neutrality

Frontiers in Energy Research, 2020
Changes in the environment due to multiple factors, such as combustion of fossil fuels, heating, transportation, deforestation, etc., have led to more greenhouse gases in the atmosphere, which eventually led to a rise in global temperatures.
Sanath Kondaveeti, Ibrahim M. Abu-Reesh, Gunda Mohanakrishna, Metin Bulut, Deepak Pant   +4 more
doaj   +1 more source

Cysteine Redox State Governs the Condensation Pathway of Hendra Virus W Protein and Differentially Impacts Type I IFN and NF‐κB Signaling

Advanced Science, EarlyView.
The cysteine redox state of the Hendra virus W (WHeV) protein controls assembly into fibrils or amorphous aggregates, with residues 2–29 required for fibrillation. In cells, WHeV forms different types of nuclear condensates. Impaired ability to form redox‐sensitive, non‐filamentous condensates reduces WHeV inhibition of the NF‐κB pathway, while it ...
Frank Gondelaud, Alexandre Lalande, Giulia Pesce, Auriane Bouchet, Carole Meunier, Christophe Bignon, Denis Ptchelkine, Yu Gu, Eva Ogire, Pierre‐Yves Lozach, Denis Gerlier, Cyrille Mathieu, Sonia Longhi   +12 more
wiley   +1 more source

Bioethanol Production via Syngas Fermentation of Clostridium Ljungdahlii in a Hollow Fiber Membrane Supported Bioreactor

International Journal of Technology, 2019
Ethanol production via syngas fermentation obtained from lignocellulose gasification provides a method to completely utilize all the carbon content from lignocellulosic feedstock.
Irika Devi Anggraini, Keryanti, Made Tri Ari Penia Kresnowati, Ronny Purwadi, Reiji Noda, Tomohide Watanabe, Tjandra Setiadi   +6 more
doaj   +1 more source

Streptavidins Coordinate Biotin Sequestration and Self‐Resistance Within a Biotin‐Pathway Antibiotic Network

Advanced Science, EarlyView.
A conserved genomic region between two streptavidin genes in Streptomyces packages biosynthetic gene clusters for diverse biotin‐pathway antibiotics: acidomycin, stravidin, the new non‐proteinogenic amino acid ANDA, and the new BioA inhibitor α‐methyl‐KAPA.
Sumire Kurosawa, Jingjun Mo, Xiaotong Diao, Feng Xie, Tingting Wang, Haowen Zhao, Dalei Wu, Rolf Müller, Chengzhang Fu   +8 more
wiley   +1 more source