Results 231 to 240 of about 17,935 (273)

Reviewer #2 (Public review): Gasdermin D-mediated neutrophil pyroptosis drives inflammation in psoriasis

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Correction: Taletrectinib promotes pyroptosis in colorectal carcinoma via SRC/AKT/mTOR axis inhibition. [PDF]

Sci Rep
Zhang T, Zou Y, Zhang SH, Wang YY, He S, Yuan W, Yang M, Liu T, Deng SH, Wu DM, Xu Y.   +10 more
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Editorial: Cell death in innate immunity and inflammatory diseases

Frontiers in Immunology
Malvina Pizzuto, Chiara Cipollina, Chiara Cipollina   +2 more
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Antibodies Targeting Gasdermin E as a Potential Therapeutic Option for Psoriasis - A Pilot Study on a Mouse Model. [PDF]

Psoriasis (Auckl)
Nowowiejska-Purpurowicz J, Hermanowicz JM, Pawlak D, Flisiak I, Lipinski T.   +4 more
europepmc   +1 more source

Starvation-induced phosphorylation activates gasdermin A to initiate pyroptosis

Xinran Li, Wei Li, Cong Xiang, Jin Cao, Jiansheng Guo, Shilei Zhu, Jingyi Tan, Lijing Wang, Chun Gao, Shengduo Liu, Lifeng Zhao, Bo Yuan, Pinglong Xu, Bing Yang, Dali Li, Bin Zhao, Xin‐Hua Feng   +16 more
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Macrophage gasdermin A (GSDMA) in systemic sclerosis.

, 2019
Moreno-Mora, Aida, Bagnati, Marta, Kotura, Surya, Jeong-Hun Ko, Fonseca, Carmen, Harmston, Nathan, Game, Laurence, Martín, Javier, Ong, Voon, Abraham, David J., Denton, Christopher, Petretto, Enrico, Behmoaras, Jacques   +12 more
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Gasdermins and cancers

Seminars in Immunology, 2023
The identification of gasdermin as the executor of pyroptosis has opened new avenues for the study of this process. Although pyroptosis research has mainly focused on immune cells since it was discovered three decades ago, accumulating evidence suggests that pyroptosis plays crucial roles in many biological processes.
Junwei Hou, Tiansheng Li, Jung-Mao Hsu, Xin Zhang, Mien-Chie Hung   +4 more
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Gasdermins and pyroptosis in the kidney

Nature Reviews Nephrology, 2023
Pyroptosis is a form of regulated cell death that is mediated by the membrane-targeting, pore-forming gasdermin family of proteins. Pyroptosis was initially described as a caspase 1- and inflammasome-dependent cell death pathway typified by the loss of membrane integrity and the secretion of cytokines such as IL-1β.
Esteban E. Elias, Brayden Lyons, Daniel A. Muruve   +2 more
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Mechanisms of Gasdermin Recognition by Proteases

Journal of Molecular Biology, 2022
Members of the gasdermin family contain positively charged N-terminal domains (NTDs) capable of binding phospholipids and assembling membrane pores, and C-terminal domains (CTDs) that bind the NTDs to prevent pore formation in the resting states. The flexible NTD-CTD linker regions of gasdermins are highly variable in length and sequences, which may be
Zhonghua Liu, Tsan Sam Xiao
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