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Gasdermins: making pores for pyroptosis
Nature Reviews Immunology, 2021Feng Shao highlights the studies that led to the discovery and definition of pyroptosis as gasdermin-mediated programmed necrotic cell death.
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Gasdermins in pyroptosis, inflammation, and cancer
Trends in Molecular MedicinePyroptosis is a type of programmed inflammatory cell death characterized by balloon-like swelling, membrane rupture, and the release of inflammatory cytokines and danger signals. Pyroptosis is directly triggered by activated gasdermins (GSDMs) which bind to membrane phospholipids, oligomerize, and form pores in cell membranes.
Rui Min +3 more
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Regulation of gasdermins in pyroptosis and cytokine release
2023Gasdermins are effectors of pyroptosis downstream of diverse signaling pathways. Emerging evidence suggests that a number of post-translational modifications regulate the function of gasdermins in pyroptosis, a highly inflammatory form of cell death, and lytic or non-lytic secretion of intracellular contents.
Sai, Li +3 more
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Versatility of gasdermin D beyond pyroptosis
Trends in Cell BiologyGasdermin D (GSDMD) has garnered significant attention primarily for the pore-forming role of its p30 N-terminal fragment (NT-p30) generated during pyroptosis, a proinflammatory form of cell death. However, emerging evidence suggests that the formation of GSDMD-NT pores is reversible, and the activation of GSDMD does not necessarily lead to pyroptosis.
Tianming Zhao, Zhexu Chi, Di Wang
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Gasdermin D opens the way for NETs
Nature Reviews Rheumatology, 2018Gasdermin D is a pore-forming protein that can cause pyroptosis, a form of inflammatory cell death. New research indicates that the pores generated by gasdermin D can also promote the formation of neutrophil extracellular traps, potentially opening new therapeutic avenues for the treatment of inflammatory diseases.
Lotte Spel, Fabio Martinon
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Mechanistic insights into gasdermin-mediated pyroptosis
Nature Reviews Molecular Cell BiologyPyroptosis, a novel mode of inflammatory cell death, is executed by membrane pore-forming gasdermin (GSDM) family members in response to extracellular or intracellular injury cues and is characterized by a ballooning cell morphology, plasma membrane rupture and the release of inflammatory mediators such as interleukin-1β (IL-1β), IL-18 and high ...
Yang Bai, Youdong Pan, Xing Liu
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Posttranslational and Therapeutic Control of Gasdermin-Mediated Pyroptosis and Inflammation
Frontiers in Immunology, 2021Fabian A Fischer +2 more
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