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Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin
Nature, 2017 Yupeng Wang, Wenqing Gao, Jingjin Ding
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Seminars in Immunology, 2023
The identification of gasdermin as the executor of pyroptosis has opened new avenues for the study of this process. Although pyroptosis research has mainly focused on immune cells since it was discovered three decades ago, accumulating evidence suggests that pyroptosis plays crucial roles in many biological processes.
Junwei Hou +4 more
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The identification of gasdermin as the executor of pyroptosis has opened new avenues for the study of this process. Although pyroptosis research has mainly focused on immune cells since it was discovered three decades ago, accumulating evidence suggests that pyroptosis plays crucial roles in many biological processes.
Junwei Hou +4 more
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Gasdermins and pyroptosis in the kidney
Nature Reviews Nephrology, 2023Pyroptosis is a form of regulated cell death that is mediated by the membrane-targeting, pore-forming gasdermin family of proteins. Pyroptosis was initially described as a caspase 1- and inflammasome-dependent cell death pathway typified by the loss of membrane integrity and the secretion of cytokines such as IL-1β.
Esteban E. Elias +2 more
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Oncolytic Parapoxvirus induces Gasdermin E-mediated pyroptosis and activates antitumor immunity
Nature Communications, 2023 Oncolytic viruses are able to target tumours and thought to induce apoptosis while remodelling the tumour immune microenvironment. Here authors show in an oncolytic parapoxvirus ovis model that pyroptosis, a highly immunogenic Gasdermin-E-dependent cell ...
Rongrong Fan, , Wenqi He
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Gasdermin and Gasdermin-Like Pore-Forming Proteins in Invertebrates, Fungi and Bacteria
Journal of Molecular Biology, 2022The gasdermin family of pore-forming proteins (PFPs) has recently emerged as key molecular players controlling immune-related cell death in mammals. Characterized mammalian gasdermins are activated through proteolytic cleavage by caspases or serine proteases, which remove an inhibitory carboxy-terminal domain, allowing the pore-formation process ...
N. Louise Glass, Asen Daskalov
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Gasdermins: making pores for pyroptosis [PDF]
Nature Reviews Immunology, 2021 Feng Shao highlights the studies that led to the discovery and definition of pyroptosis as gasdermin-mediated programmed necrotic cell death.
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Coral gasdermin triggers pyroptosis
Science Immunology, 2020Coral gasdermin is activated by caspase 3 and involved in pathogen-induced coral death.
Shuai Jiang, Zhi Zhou, Li Sun
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Mechanisms of Gasdermin Recognition by Proteases
Journal of Molecular Biology, 2022Members of the gasdermin family contain positively charged N-terminal domains (NTDs) capable of binding phospholipids and assembling membrane pores, and C-terminal domains (CTDs) that bind the NTDs to prevent pore formation in the resting states. The flexible NTD-CTD linker regions of gasdermins are highly variable in length and sequences, which may be
Tsan Sam Xiao +3 more
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