Results 321 to 330 of about 24,180 (354)

Evolution of the gasdermin family and pyroptosis

Developmental & Comparative Immunology, 2023
Gasdermins have been identified as playing a prominent role in the innate immune response as the executors of a specific type of cell death called pyroptosis. Specific proteolytic cleavage of gasdermins generates an N-terminal that oligomerizes and forms pores in the cell membrane.
Diego Angosto-Bazarra, Adriana Guijarro, Pablo Pelegrín   +2 more
openaire   +2 more sources

Palmitoylation at a conserved cysteine residue facilitates gasdermin D-mediated pyroptosis and cytokine release

Proceedings of the National Academy of Sciences of the United States of America
Significance Pyroptosis is an inflammatory form of cell death that plays important roles in host defense and inflammatory disorders. Despite intensive studies, the molecular events underlying the gasdermin D (GSDMD)-mediated pyroptosis remain poorly ...
Zhonghua Liu, Sai Li, Chuanping Wang, Kaylynn J Vidmar, Syrena Bracey, Ling Li, Belinda Willard, Masaru Miyagi, Tong Lan, Bryan C. Dickinson, A. Osme, Theresa T. Pizarro, T. S. Xiao   +12 more
semanticscholar   +1 more source

Gasdermin D opens the way for NETs [PDF]

Nature Reviews Rheumatology, 2018
Gasdermin D is a pore-forming protein that can cause pyroptosis, a form of inflammatory cell death. New research indicates that the pores generated by gasdermin D can also promote the formation of neutrophil extracellular traps, potentially opening new therapeutic avenues for the treatment of inflammatory diseases.
Lotte Spel, Fabio Martinon
openaire   +2 more sources

Dual-Responsive Epigenetic Inhibitor Nanoprodrug Combined with Oncolytic Virus Synergistically Boost Cancer Immunotherapy by Igniting Gasdermin E-Mediated Pyroptosis.

ACS Nano
Cancer immunotherapy has emerged as a promising approach for the treatment of various cancers. However, the immunosuppressive tumor microenvironment (TME) limits the efficacy of current immunotherapies.
Yuan-Yuan Wang, Jingting Wang, Shuo Wang, Qi-Chao Yang, A. Song, Meng‐Jie Zhang, Wen-Da Wang, Yuan-Tong Liu, Junjie Zhang, Wei-Ming Wang, Zhigang Xu, Zhijun Sun   +11 more
semanticscholar   +1 more source

Pyroptosis, gasdermins and allergic diseases

Allergy
AbstractPyroptosis is an inflammatory form of programmed cell death that is distinct from necrosis and apoptosis. Pyroptosis is primarily mediated by the gasdermin family of proteins (GSDMA‐E and PVJK), which, when activated by proteolytic cleavage, form pores in the plasma membrane, leading to cell death.
Ronald Allan Panganiban, Kari C. Nadeau, Quan Lu   +2 more
openaire   +2 more sources

NK-cell–elicited gasdermin-D–dependent hepatocyte pyroptosis induces neutrophil extracellular traps that facilitate HBV-related acute-on-chronic liver failure

Hepatology
Background and Aims: HBV infection is a major etiology of acute-on-chronic liver failure (ACLF). At present, the pattern and regulation of hepatocyte death during HBV-ACLF progression are still undefined.
Qiang Zhao, Dong-Ping Chen, Hua-Di Chen, Ying-Zhe Wang, Wei Shi, Yi-Tong Lu, Yi-Zheng Ren, Yuan-Kai Wu, Yi-Hua Pang, Hong Deng, Xiaoshun He, Dong-Ming Kuang, Zhiyong Guo   +12 more
semanticscholar   +1 more source

Gasdermin D permeabilization of mitochondrial inner and outer membranes accelerates and enhances pyroptosis.

Immunity, 2023
Rui Miao, Cong Jiang, Winston Y. Chang, Haiwei Zhang, Jinsu An, Felicia Ho, Pengcheng Chen, Han Zhang, Caroline Junqueira, Dulguun Amgalan, Felix G Liang, Junbing Zhang, Charles L. Evavold, Iva Hafner-Bratkovič, Zhibin Zhang, Pietro Fontana, S. Xia, Markus Waldeck-Weiermair, Youdong Pan, Thomas Michel, L. Bar-Peled, Hao Wu, Jonathan C. Kagan, R. Kitsis, Peng Zhang, Xing Liu, Judy Lieberman   +26 more
semanticscholar   +1 more source

Gasdermins in pyroptosis, inflammation, and cancer

Trends in Molecular Medicine
Pyroptosis is a type of programmed inflammatory cell death characterized by balloon-like swelling, membrane rupture, and the release of inflammatory cytokines and danger signals. Pyroptosis is directly triggered by activated gasdermins (GSDMs) which bind to membrane phospholipids, oligomerize, and form pores in cell membranes.
Rui Min, Yang Bai, Ning-Rui Wang, Xing Liu   +3 more
openaire   +2 more sources

Gasdermin splicing

Nature Immunology, 2023
openaire   +2 more sources

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

Nature, 2015
N. Kayagaki, Irma B. Stowe, Bettina L. Lee, K. O’Rourke, Keith Anderson, S. Warming, Trinna L Cuellar, B. Haley, M. Roose-Girma, Q. Phung, Peter S. Liu, J. Lill, Hong Li, Jiansheng Wu, S. Kummerfeld, Juan Zhang, Wyne P. Lee, S. Snipas, G. Salvesen, L. X. Morris, L. Fitzgerald, Yafei Zhang, E. Bertram, C. Goodnow, V. Dixit   +24 more
semanticscholar   +1 more source