Results 261 to 270 of about 64,020 (335)

Glucose-dependent insulinotropic polypeptide/gastric inhibitory polypeptide

Best Practice and Research in Clinical Endocrinology and Metabolism, 2004
The 42 amino acid polypeptide glucose-dependent insulinotropic polypeptide/gastric inhibitory polypeptide (GIP) is released from intestinal K-cells in response to nutrient ingestion. Based on animal studies, the peptide was initially assumed to act as an endogenous inhibitor of gastric acid secretion.
Juris J Meier, Michael A Nauck
exaly   +2 more sources

Identification and Actions of Gastric Inhibitory Polypeptide

Recent Progress in Hormone Research, 1975
Publisher Summary This chapter gives an overview of the identification and actions of gastric inhibitory polypeptide (GIP). It describes an experiment in which it is concluded that exogenous or endogenous GIP is capable of insulinotropic effects in normal man and can lead to substantial acceleration of the disposal of glucose.
J C, Brown, J R, Dryburgh, S A, Ross, J, Dupré   +3 more
openaire   +3 more sources

Lipid photosensitizers for suppression of gastric inhibitory polypeptide in obese with type 2 diabetes.

Biomaterials, 2020
"K-cell targeted photodynamic therapy (K-cell targeted PDT)" with a minimally invasive procedure was investigated to reduce the secretion of gastric inhibitory polypeptide (GIP), an incretin hormone secreted from enteroendocrine K-cells in the duodenum ...
Sanghee Lee, K. Na
semanticscholar   +1 more source

Gastric Inhibitory Polypeptide

Clinics in Gastroenterology, 1980
The available data show that GIP is at present the strongest candidate for the insulin-secreting factor of the gut named incretin. Its release is triggered by the absorption of ingested nutrients. GIP acts on the B-cells of the pancreas by potentiating glucose-induced insulin secretion. The role of GIP as an enterogastrone is less well established. The
R, Ebert, W, Creutzfeldt
openaire   +2 more sources

Clinical studies with gastric inhibitory polypeptide

World Journal of Surgery, 1979
AbstractIntravenous infusion of porcine GIP in man induces insulin release when a degree of hyperglycemia is present. This glucose‐dependent insulinotropic response occurs when a dose of GIP is administered to obtain circulating levels of approximately 1 ng/ml, a physiologic level that can be achieved by the ingestion of glucose or corn oil or a mixed ...
J C, Brown, S, Otte
openaire   +2 more sources

Gastric Inhibitory Polypeptide

Comprehensive Physiology, 1989
Abstract The sections in this article are: Gastric Inhibitory Effect of Gastric Inhibitory Polypeptide Insulinotropic Action of GIP
John C Brown, Alison M. J. Buchan, Christopher H. S. McIntosh, Raymond A. Pederson   +3 more
openaire   +1 more source

The Insulinotropic Action of Gastric Inhibitory Polypeptide

Canadian Journal of Physiology and Pharmacology, 1975
The effect of highly purified gastric inhibitory polypeptide (GIP) on immunoreactive insulin (IRI) secretion in the conscious fasted dog was investigated. Significant increases in IRI release were observed with intravenous administration of three different doses of GIP. These were accompanied by depression in fasting serum-glucose levels.
R A, Pederson, H E, Schubert, J C, Brown
openaire   +2 more sources

Immunoreactive Gastric Inhibitory Polypeptide*

Endocrine Reviews, 1988
IN 1906 extracts of mucosa from the upper small intestine from pigs were tested as a treatment of diabetes in the hope that “the internal secretion of the pancreas might be stimulated and initiated by the substance of the nature of a hormone yielded by the duodenal mucous membrane” (1).
openaire   +2 more sources

The Hepatic Extraction of Gastric Inhibitory Polypeptide and Insulin*

Endocrinology, 1984
The hepatic extractions of gastric inhibitory polypeptide (GIP) and insulin were determined using in vitro and in vivo methods to assess the role of the liver in GIP metabolism and the possible effect of GIP on the hepatic extraction of insulin. During in vitro studies using the isolated perfused rat liver, infusion of GIP (2000 pg/ml) alone and in ...
J B, Hanks, D K, Andersen, J E, Wise, W S, Putnam, W C, Meyers, R S, Jones   +5 more
openaire   +2 more sources

A RADIOIMMUNOASSAY OF GASTRIC INHIBITORY POLYPEPTIDE IN HUMAN PLASMA

Journal of Endocrinology, 1980
A sensitive radioimmunoassay for the measurement of human gastric inhibitory polypeptide (GIP), using pure porcine GIP, has been developed. Cross-reactivity of the antiserum with all available mammalian gut peptide preparations was negligible with the exception of glucagon when it was approximately 1%.
D L, Sarson, M G, Bryant, S R, Bloom
openaire   +2 more sources