Results 41 to 50 of about 18,988 (214)

Helicobacter pylori promotes gastric intestinal metaplasia through activation of IRF3-mediated kynurenine pathway

Cell Communication and Signaling, 2023
Background Metabolic reprogramming is a critical event for cell fate and function, making it an attractive target for clinical therapy. The function of metabolic reprogramming in Helicobacter pylori (H.
Xinhua Liang, Wenjun Du, Ling Huang, Li Xiang, Wenxu Pan, Fangying Yang, Fengfeng Zheng, Yongwu Xie, Lanlan Geng, Sitang Gong, Wanfu Xu   +10 more
doaj   +1 more source

Intestinal Metaplasia and the Risk of Gastric Cancer in an Immigrant Asian Population

, 2012
The development of intestinal metaplasia (IM) has been purported to be a critical step in the pathogenesis of gastric cancer. However, the natural history of IM in migrant human populations has not been well elucidated.
Christine Brezden-Masley, Andrea Grin, Amir Abadir, Young-In Kim, Catherine Streutker   +4 more
core   +1 more source

hTERT, MYC and TP53 deregulation in gastric preneoplastic lesions

BMC Gastroenterology, 2012
Background Gastric cancer is a serious public health problem in Northern Brazil and in the world due to its high incidence and mortality. Despite the severity of the disease, more research is needed to better understand the molecular events involved in ...
Silva Tanielly Cristina, Leal Mariana, Calcagno Danielle, de Souza Carolina Rosal, Khayat André, dos Santos Ney Pereira, Montenegro Raquel, Rabenhorst Silvia Helena, Nascimento Mayara, Assumpção Paulo, de Arruda Cardoso Smith Marília, Burbano Rommel   +11 more
doaj   +1 more source

Advances in Gastric Cancer Research: Insights Into Carcinogenesis, the Tumor Microenvironment, Metastasis, and Factors Influencing Prognosis

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Background The Department of Gastroenterological Surgery at Kumamoto University has maintained a commitment to integrating cutting‐edge clinical practice with fundamental research, particularly concerning malignant diseases of the digestive tract.
Hideo Baba, Takatsugu Ishimoto, Yoshifumi Baba, Hiromitsu Hayashi, Masaaki Iwatsuki   +4 more
wiley   +1 more source

Prevalência de metaplasia intestinal na junção esofagogástrica no Instituto de Endiscopia do Planalto [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Ciências Médicas, Florianópolis, 2006.Os estudos de prevalência de metaplasia intestinal na junção esofagogástrica são recentes na ...
Guzatti Fiho, Osmar
core  

Blood Biomarkers of Helicobacter pylori‐Infected Chronic Gastritis in Active Versus Stable Phases: A Clinical Indicator Analysis Combined With Proteomic and Metabolomic Investigations

iMetaMed, EarlyView.
Combining clinical data with serum proteomics and metabolomics, the HGB–CAPZB–acetic acid model was developed as a potential diagnostic index to distinguish the active and stable stages of Helicobacter pylori‐infected chronic gastritis, and the related mechanism was explored through multi‐omics.
Tiantong Jiang, Zhen Ma, Yang Li, Shaoli Wang, Yanjiao Zhang, Lei Song, Xianyu Li, Zhen Liu   +7 more
wiley   +1 more source

Helicobacter pylori with stronger intensity of CagA phosphorylation lead to an increased risk of gastric intestinal metaplasia and cancer

BMC Microbiology, 2011
Background Nearly all Taiwanese H. pylori stains are cagA-genopositive and encode CagA protein. In this study, we evaluated whether different intensity of tyrosine phosphorylated-CagA (p-CagA) had an impact on the clinical diseases and histological ...
Cheng Hsiu-Chi, Wu Jiunn-Jong, Hung Kuei-Hsiang, Sheu Shew-Meei, Yang Hsiao-Bai, Chuang Chiao-Hsiung, Chang Wei-Lun, Sheu Bor-Shyang   +7 more
doaj   +1 more source

YAP targetome reveals activation of SPEM in gastric pre-neoplastic progression and regeneration

Cell Reports, 2023
Summary: Peptic ulcer disease caused by environmental factors increases the risk of developing gastric cancer (GC), one of the most common and deadly cancers in the world. However, the mechanisms underlying this association remain unclear.
Adrian K.H. Loe, Abilasha Rao-Bhatia, Zhao Wei, Jung-Eun Kim, Bingxin Guan, Yan Qin, Minji Hong, Hyo Sang Kwak, Xiaoyu Liu, Leyi Zhang, Jeffrey L. Wrana, Haiyang Guo, Tae-Hee Kim   +12 more
doaj   +1 more source

Multi‐omics biomarkers for intestinal infection and inflammation in inflammatory bowel disease: Current evidence, translational challenges, and diagnostic opportunities

Interdisciplinary Medicine, EarlyView.
Prospective multi‐site cohorts, multi‐omics profiling, and computational analysis may help identify biomarker patterns across clinical settings in IBD and superimposed infections. With further mechanistic and clinical validation, these signals could support the development of practical multi‐analyte tools for more precise diagnosis and management ...
Ziyu Yang, Jiayi Yao, Xinxian Zhao, Yan Xu, Yifan Chen, Tianchi Chen, Ying Jian, Min Li   +7 more
wiley   +1 more source

Do we need gastric acid? [PDF]

, 2008
Evidence from comparative anatomy and physiology studies indicates that gastric acid secretion developed during the evolution of vertebrates approximately 350 million years ago.
Lippl, F., Lippl, F, Schiefke, I, Prinz, C., Pohl, D, Rogler, G., Prinz, C, Fox, M, Mönnikes, H, Schiefke, I., Keller, J, Seidler, U, Allescher, H D, Dauer, M, Göke, B., Seidler, U., Keller, J., Fox, M., Göke, B, Pohl, D., Moennikes, H., Dauer, M., Rogler, G, Kandahar Study Group, Fried, M, Allescher, H. D.   +25 more
core   +1 more source