Results 31 to 40 of about 2,001 (186)

Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics

British Journal of Clinical Pharmacology, EarlyView.
Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay, Amandine Manon, Hunter Stephens, S. Y. Amy Cheung, Bart de Keizer, Erik T. te Beek   +5 more
wiley   +1 more source

Pak2 regulates hematopoietic progenitor cell proliferation, survival and differentiation [PDF]

, 2015
p21-Activated kinase 2 (Pak2), a serine/threonine kinase, has been previously shown to be essential for hematopoietic stem cell (HSC) engraftment. However, Pak2 modulation of long-term hematopoiesis and lineage commitment remain unreported.
Broxmeyer, Hal E., Chernoff, Jonathan, Chitteti, Brahmananda Reddy, Clapp, Wade, Cooper, Scott, Hahn, Seongmin, Jiang, Li, Kosoff, Rachelle, Park, Su-Jung, Sandusky, George, Srour, Edward F., Staser, Karl, Sun, Zejin, Yang, XianLin, Yuan, Jin, Zeng, Yi   +15 more
core   +1 more source

Gastric duplication cyst causing hypergastrinemia in an infant

JPGN Reports, EarlyView.
Abstract Gastric duplication cysts are rare congenital anomalies, with fewer than 10% occurring in the stomach. We report a 14‐month‐old girl presenting with failure to thrive, recurrent emesis, hematemesis, and severe duodenitis with ulceration. Laboratory evaluation revealed marked hypergastrinemia (1781 pg/mL), and initial imaging was unrevealing ...
Nathan Bryan, Ian Leibowitz
wiley   +1 more source

Helicobacter pylori Infection Promotes Methylation and Silencing of Trefoil Factor 2, Leading to Gastric Tumor Development in Mice and Humans [PDF]

, 2010
Background & Aims Trefoil factors (TFFs) regulate mucosal repair and suppress tumor formation in the stomach. Tff1 deficiency results in gastric cancer, whereas Tff2 deficiency increases gastric inflammation.
Fox, James G., Giraud, Andrew S., Judd, Louise M., Kawakami, Kazuyuki, Menheniott, Trevelyan R., Minamoto, Toshinari, O'Connor, Louise, Ong, Eng Kok, Peterson, Anthony J., Walduck, Anna K., Wang, Timothy C.   +10 more
core   +1 more source

Biological activities and bioactive constituents of Flammulina velutipes: An updated systematic review

Journal of the Science of Food and Agriculture, EarlyView.
Abstract Flammulina velutipes (enokitake) is an edible mushroom recognized for both its nutritional and medicinal properties. It exhibits a broad spectrum of biological activities, including antioxidant, anti‐inflammatory, antitumor, immunomodulatory, and gut microbiota‐regulating effects.
Rıdvan Özgen, Didem Şöhretoğlu, Ayşe Kuruüzüm‐Uz   +2 more
wiley   +1 more source

PTPσ inhibitors promote hematopoietic stem cell regeneration. [PDF]

, 2019
Receptor type protein tyrosine phosphatase-sigma (PTPσ) is primarily expressed by adult neurons and regulates neural regeneration. We recently discovered that PTPσ is also expressed by hematopoietic stem cells (HSCs).
Chute, John P, Damoiseaux, Robert, Diers, Emelyne, Fang, Tiancheng, Himburg, Heather, Jin Gim, Hyo, Jung, Michael E, Kan, Jenny, Li, Michelle, McBride, William, Pohl, Katherine, Quarmyne, Mamle, Roos, Martina, Termini, Christina M, Whitelegge, Julian, Yan, Xiao, Zhang, Yurun, Zhao, Liman   +17 more
core   +1 more source

Exocrine Gland Dysfunction in Parkinson's Disease: Pathophysiology, Clinical Manifestations, and Therapeutic Perspectives—A Narrative Review

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Non‐motor symptoms, especially autonomic dysfunction, are major contributors to disability and decreased quality of life in Parkinson's disease (PD). Despite being common and having a wide range of clinical facets, exocrine gland dysfunction is still not well recognized and managed.
Renato P. Munhoz, Marina Farah, Laura Silveira‐Moriyama   +2 more
wiley   +1 more source

Evidence map and gap analysis of metabolic change in pediatric growth hormone deficiency treated with growth hormone

Pediatric Investigation, EarlyView.
This evidence map of 63 studies (n = 6158) showed growth hormone therapy in children with growth hormone deficiency has neutral glucose effects, mixed lipid outcomes, potential benefits for bone mineral density, bone mineral content, and parathyroid hormone, but generally no impact on thyroid function, body composition, or body mass index.
Wei Wu, Ningyi Song, Yue Zhao, Caiqi Du, Yuning Zhao, You Wu, Xiaoping Luo   +6 more
wiley   +1 more source

Proteomic and metabolic signatures of female reproductive factors and risk of age‐related ocular diseases: A large prospective cohort study

VIEW, EarlyView.
The full editable vector source file of this graphical abstract is uploaded as a supplementary EPS file for typesetting. All elements are copyright‐free. Abstract Age‐related ocular diseases (ARODs), including cataract, primary open‐angle glaucoma (POAG), and age‐related macular degeneration (AMD), are leading causes of vision impairment and exhibit ...
Linge Jian, Zhiqian Huang, Keke Zhang, Jing Lin, Jia You, Yi Lu, Xiangjia Zhu   +6 more
wiley   +1 more source

Surgical Management of Zollinger‐Ellison Syndrome in Multiple Endocrine Neoplasia Type 1 an AFCE and GTE Cohort Study. (Association Francophone de Chirurgie Endocrinienne and Groupe d'étude des Tumeurs Endocrines)

World Journal of Surgery, EarlyView.
To describe surgical indications, procedures and outcomes in patients operated for Zollinger‐Ellison syndrome (ZES) in multiple endocrine neoplasia type 1 (MEN1) using a large nationwide cohort. ABSTRACT Objective To describe surgical indications, procedures and outcomes in patients operated for Zollinger‐Ellison syndrome (ZES) in multiple endocrine ...
Sébastien Gaujoux, François Pattou, Guillaume Cadiot, Mustapha Adham, Philippe Bachellier, Jean‐Pierre Bail, Robert Caiazzo, Nicolas Carrere, Philippe Chaffanjon, Sophie Deguelte, Gianluca Donatini, Bertrand Dousset, Matthieu Faron, Caroline Gronnier, Bruno Heyd, Jean‐Christophe Lifante, Jean Lubrano, Nicolas Meurisse, Eric Mirallié, Nicolas Santucci, Alain Sauvanet, Frédéric Sebag, Laurent Sulpice, Baudoin Thebault, Jean‐Jacques Tuech, Thomas Walter, Christine Binquet, Pierre Goudet   +27 more
wiley   +1 more source