Results 11 to 20 of about 1,657 (182)
Gastrins and gastrinomas [PDF]
Postgraduate Medical Journal, 1984 Summary The past 20 years have seen gastrin attain true hormonal status. Its structure has been characterized, it has been synthesized, radioimmunoassays for its measurement in blood and tissues have been developed and its physiology and metabolism elucidated.
J. Hansky
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Gastrin and the Moderate Hypergastrinemias. [PDF]
Int J Mol Sci, 2021 The antral hormone gastrin potently regulates gastric acid secretion and fundic mucosal growth. Consequently, appropriate gastrin secretion and plasma concentrations are important for the early phases of digestion. This review describes as the first premise the normal biogenesis of gastrin in the antral mucosa, but also mentions the extraantral ...
Rehfeld JF.
europepmc +6 more sources
Gastrin, gastrin receptors and colorectal carcinoma [PDF]
Gut, 1998 The possibility that gastrin may play a role in the development of colorectal carcinoma has aroused considerable interest over the past decade. In early reports some colorectal carcinomas and colorectal carcinoma cell lines were shown to produce gastrin,1 to express gastrin receptors,2 and to respond mitogenically to exogenous gastrin.2 The most ...
G S, Baldwin, A, Shulkes
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The Lancet, 1965 The Lancet 285 (1965) 816-816.
University of Florida, Gainesville, United States. ( host institution ) +1 more
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Gastrins, iron homeostasis and colorectal cancer [PDF]
, 2011 The peptide hormone gastrin has been identified as a major regulator of acid secretion and a potent mitogen for normal and malignant gastrointestinal cells. The importance of gastric acid in the absorption of dietary iron first became evident 50years ago
Kovac, Suzana +5 more
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Gut, 1972 Gastrin release in the basal state and following a standard protein meal has been estimated in patients after partial gastrectomy, partial gastrectomy with truncal vagotomy, and total gastrectomy. Following partial gastrectomy, gastrin rose from 8 ± 0·8 to 20 ± 3·8 pg/ml with a protein meal.
M G, Korman, C, Soveny, J, Hansky
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Demonstration and biological significance of a gastrin-P21-activated kinase 1 feedback loop in colorectal cancer cells [PDF]
, 2014 Gastrins, including amidated gastrin17 and glycine-extended gastrin17, are important growth factors in colorectal cancer (CRC). The p21-activated kinase 1 (PAK1) plays key roles in cellular processes including proliferation, survival, and motility, and ...
Huynh, N +5 more
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Gastroenterology, 1970 Summary A highly specific radioimmunoassay for endogenous human plasma gastrin was developed using guinea pig antisera to crude porcine gastrin. Highly purified 125 I-porcine gastrin I, further purified on starch gel electrophoresis after labeling, was employed as tracer, and an anionic exchange resin was used to separate bound and free labeled ...
R S, Yalow, S A, Berson
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Gastrin increases its own synthesis in gastrointestinal cancer cells via the CCK2 receptor [PDF]
, 2010 The involvement of the gastrointestinal hormone gastrin in the development of gastrointestinal cancer is highly controversial. Here we demonstrate a positive-feedback loop whereby gastrin, acting via the CCK2 receptor, increases its own expression.
Kovac, Suzana +9 more
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Gastrin mediates resistance to hypoxia-induced cell death in xenografts of the human colorectal cancer cell line LoVo [PDF]
, 2014 Aim: Gastrins act as growth factors for the normal and neoplastic colorectal mucosa. The aim of this study was to determine the role of gastrins in the response of human colorectal cancer (CRC) cells to hypoxia in vitro and in vivo.
Westwood, David A. +2 more
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