Results 11 to 20 of about 1,490 (145)
TP53 R249S mutation in hepatic organoids captures the predisposing cancer risk
Hepatology, EarlyView., 2022 The systematic approach in elucidating the gain‐of‐function (GOF) roles of TP53 mutations in early liver carcinogenesis. Unique downstream targets of TP53 L3 mutations were identified from chormatin immunoprecipitation sequencing in HCC cell lines, followed by a series of validation assays to substantiate the exclusive transcriptional regulations ...
Yin Kau Lam +10 more
wiley +1 more source
Gut, 1972 Gastrin release in the basal state and following a standard protein meal has been estimated in patients after partial gastrectomy, partial gastrectomy with truncal vagotomy, and total gastrectomy. Following partial gastrectomy, gastrin rose from 8 ± 0·8 to 20 ± 3·8 pg/ml with a protein meal.
M G, Korman, C, Soveny, J, Hansky
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High Affinity Binding of Indium and Ruthenium Ions by Gastrins.
PLoS ONE, 2015 The peptide hormone gastrin binds two ferric ions with high affinity, and iron binding is essential for the biological activity of non-amidated forms of the hormone.
Graham S Baldwin +2 more
doaj +1 more source
Antral Gastrin Cell Hyperfunction Associated with Chronic Pancreatitis
Canadian Journal of Gastroenterology, 1988 This report describes a patient with antral gastrin cell hyperfunction who also had pancreatic pseudocyts and partial common bile duct obstruction secondary to chronic pancreatitis. A 60-year-old female had a th ree-month h istory of worsening epigastric
Atilla Ertan +3 more
doaj +1 more source
Gastroenterology, 1970 Summary A highly specific radioimmunoassay for endogenous human plasma gastrin was developed using guinea pig antisera to crude porcine gastrin. Highly purified 125 I-porcine gastrin I, further purified on starch gel electrophoresis after labeling, was employed as tracer, and an anionic exchange resin was used to separate bound and free labeled ...
R S, Yalow, S A, Berson
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Gastrins and gastrinomas [PDF]
Postgraduate Medical Journal, 1984 Summary The past 20 years have seen gastrin attain true hormonal status. Its structure has been characterized, it has been synthesized, radioimmunoassays for its measurement in blood and tissues have been developed and its physiology and metabolism elucidated.
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FEBS Letters, EarlyView.Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi +5 more
wiley +1 more source
Revista do Colégio Brasileiro de CirurgiõesOBJETIVO: A obesidade mórbida é uma doença crônica que se acompanha de várias complicações médicas e de uma menor esperança de vida, prejudicando o aspecto físico, emocional, econômico e social.
Pedro Luiz Squilacci Leme +5 more
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Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Gastrin and Gastric Cancer [PDF]
Frontiers in Endocrinology, 2017 Gastric cancer although occurring in reduced frequency is still an important disease, partly because of the bad prognosis when occurring in western countries. This decline in occurrence may mainly be due to the reduced prevalence of Helicobacter pylori (Hp) infection, which is the most important cause of gastric cancer.
Waldum, Helge +2 more
openaire +3 more sources