Results 11 to 20 of about 2,001 (186)

TP53 R249S mutation in hepatic organoids captures the predisposing cancer risk

Hepatology, EarlyView., 2022
The systematic approach in elucidating the gain‐of‐function (GOF) roles of TP53 mutations in early liver carcinogenesis. Unique downstream targets of TP53 L3 mutations were identified from chormatin immunoprecipitation sequencing in HCC cell lines, followed by a series of validation assays to substantiate the exclusive transcriptional regulations ...
Yin Kau Lam, Jianqing Yu, Hao Huang, Xiaofan Ding, Alissa M. Wong, Howard H. Leung, Anthony W. Chan, Kelvin K. Ng, Mingjing Xu, Xin Wang, Nathalie Wong   +10 more
wiley   +1 more source

Occurrence of gastric cancer and carcinoids in atrophic gastritis during prospective long-term follow up [PDF]

, 2015
Objective. Atrophic gastritis (AG) is a risk condition for gastric cancer and type I gastric carcinoids. Recent studies assessing the overall risk of gastric cancer and carcinoids in AG at long-term follow up are lacking.
Annibale, Bruno, Corleto, Vito Domenico, DI GIULIO, Emilio, Esposito, Gianluca, Lahner, Edith, Pilozzi, Emanuela, Purchiaroni, Flaminia   +6 more
core   +2 more sources

Effects of myoinhibitory peptides on food intake in the German cockroach [PDF]

, 2017
Insect myoinhibitory peptides were discovered through their inhibitory activity on visceral muscle contraction. The present study tests the antimyotropic gut properties of three galanin-related myoinhibitory peptides (Mas-MIP II: GWQDLNSAW-NH2; Grb-AST ...
Aguilar, Ruth, Bellés, Xavier, Maestro, José L.   +2 more
core   +1 more source

Antral Gastrin Cell Hyperfunction Associated with Chronic Pancreatitis

Canadian Journal of Gastroenterology, 1988
This report describes a patient with antral gastrin cell hyperfunction who also had pancreatic pseudocyts and partial common bile duct obstruction secondary to chronic pancreatitis. A 60-year-old female had a th ree-month h istory of worsening epigastric
Atilla Ertan, Martin S. Litwin, Robert A. Hammer, Paul Vega   +3 more
doaj   +1 more source

Impact of clinically tested NEP/ACE inhibitors on tumor uptake of [111In-DOTA]MG11 [PDF]

, 2016
Background: We have recently shown that treatment of mice with the neutral endopeptidase (NEP) inhibitor phosphoramidon (PA) improves the bioavailability and tumor uptake of biodegradable radiopeptides.
Jong, M. (Marion) de, Kaloudi, A. (Katerina), Krenning, E.P. (Eric), Lymperis, E. (Emmanouil), Maina, T. (Theodosia), Nock, B.A. (Berthold), Valkema, R. (Roelf)   +6 more
core   +5 more sources

Predicting sulfotyrosine sites using the random forest algorithm with significantly improved prediction accuracy [PDF]

, 2009
© 2009 Yang; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction ...
Zheng Rong Yang, A Hille, BN Andersen, EM Danielsen, M Negishi, B Leitinger, JW Kehoe, C Seibert, J Liu, AH Plaas, MW Coughtrie, CY Koo, NA Dumas, Y Hui, Y Wang, AJ Sakko, YH Teng, SS Skandalis, J Li, N Bloushtain, LJ Otvos, J Wolfender, MW Coughtrie, JD Buxbaum, M Hasegawa, GL Caporaso, F Monigatti, HC Lin, RA Poorman, ZR Yang, F Monigatti, TD Schneider, V Vacic, E Freyhult, JL Cornette, TE Creighton, DW Urry, E Georges, M Neuwirth, T Nomura, J Sohn, J Pevsner, KJ Archer, BD Ripley, PP Wilkins, T Pouyani, D Sako, WS Somers, AJ Hoffhines, M Furuse, ZW Fan, Y Matsubayashi, RA Barkley, RW Ellwood, K Matier-Sharma, JN Wherry, JM Ostell, W Li, W Li, W Li, WN Venables, L Breiman, L Breiman, V Vapnik, DE Rumelhart, CE Metz, B Efron, T Sing, B Efron, O Tastan, XY Wu, J Olsen, MC Abba, K Hoffmann, Y Qi   +74 more
core   +1 more source

Matrix metalloproteinase (MMP)-7 in Barrett’s esophagus and esophageal adenocarcinoma : expression, metabolism and functional significance [PDF]

, 2018
Supported by grants from North West Cancer Research (Grant number: CR945), The Wellcome Trust (Grant number: 074287/Z/03/Z) and a research studentship (HG) from the Libyan Government.Matrix metalloproteinase (MMP)‐7, unlike many MMPs, is typically ...
Beynon, Rob, Dockray, Graham J, Dodd, Steven, Garalla, Hanan M, Holmberg, Chris, Kumar, Jothi Dinesh, Lertkowit, Nantaporn, Moore, Andrew R, Pritchard, David Mark, Reisz, Zita, Rosztóczy, András I, Simpson, Alec, Simpson, Deborah, Tiszlavicz, Laszlo, Varga, Akos, Varro, Andrea, Wittman, Tibor   +16 more
core   +4 more sources

Non-Steroidal Anti-Inflammatory Drugs in the Carcinogenesisof the Gastrointestinal Tract [PDF]

, 2010
It is estimated that underlying infections and inflammatory responses are linked to 15–20% of all deaths from cancer worldwide. Inflammation is a physiologic process in response to tissue damage resulting from microbial pathogen infection, chemical ...
COMPARE, DEBORA, NARDONE, GERARDO ANTONIO PIO, O. M. Nardone   +2 more
core   +2 more sources

Exclusão gastroduodenal e vagotomia troncular: repercussão no peso corporal e gastrinemia- estudo experimental em ratos

Revista do Colégio Brasileiro de Cirurgiões
OBJETIVO: A obesidade mórbida é uma doença crônica que se acompanha de várias complicações médicas e de uma menor esperança de vida, prejudicando o aspecto físico, emocional, econômico e social.
Pedro Luiz Squilacci Leme, Carlos Alberto Malheiros, Francisco Cesar Martins Rodrigues, Andréia Bonizzia Zanqui, Darcy Lisbão Moreira de Carvalho, Fares Rahal   +5 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source