Results 41 to 50 of about 1,490 (145)

Real‐World Prognostic Analysis of Clinical Characteristics in Extensive‐Stage Small Cell Lung Cancer: A Nomogram for Survival Prediction in Patients Receiving First‐Line Immunochemotherapy With Serplulimab

Cancer Medicine, Volume 15, Issue 8, August 2026.
Among 239 patients reviewed, 109 patients with extensive‐stage small‐cell lung cancer receiving first‐line serplulimab‐based immunochemotherapy were included. A nomogram incorporating liver metastasis, maintenance therapy, albumin, and neutrophil‐to‐lymphocyte ratio predicted overall survival and significantly stratified patients into three risk groups
Ying Zhu, Zhongwen Li, Ming Zhang, Yuyun Lan, Yarong Wang, Yao Liu, Yibing Liu   +6 more
wiley   +1 more source

Goniothalamin as a Styryl‐Lactone Toxicophore in Cancer Models: Electrophile‐Driven DNA Damage, Reactive Oxygen Species–Endoplasmic Reticulum Stress Signaling and Detoxification‐Relevant Safety Considerations

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
Goniothalamin (GTN) exerts anticancer effects by promoting reactive oxygen species (ROS) generation, glutathione (GSH) depletion, DNA damage, endoplasmic reticulum (ER) stress, and mitochondrial dysfunction. These interconnected events trigger apoptosis, necroptosis, anoikis, and autophagy, while modulating mitogen‐activated protein kinase (MAPK ...
Nataša Joković, Strahinja Pešić, Marija Novaković, Anđela Dubroja Krstić, William N. Setzer, Javad Sharifi‐Rad, Daniela Calina   +6 more
wiley   +1 more source

Efficacy and Tolerability of Tegoprazan Compared to Proton Pump Inhibitors in the Treatment of Erosive Esophagitis: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

JGH Open, Volume 10, Issue 8, August 2026.
ABSTRACT Aim Tegoprazan, a potassium‐competitive acid blocker, is an acid‐suppressing medication under review as a potential alternative treatment in cases of erosive esophagitis. This systematic review and meta‐analysis assesses the efficacy and tolerability of tegoprazan compared to proton pump inhibitors, the current standard of care. Methods Pubmed,
Youssef Diab, Charbel Maalouf, Anthony Junior Al Hakim, Perla Chami, Ali Ghais, Etwal Bou Raad, Louis Chaptini   +6 more
wiley   +1 more source

Small Cell Lung Cancer Associated With Cystic Airspace: A Case Report and Literature Review

Respirology Case Reports, Volume 14, Issue 8, August 2026.
We report a rare case of small cell lung cancer (SCLC) associated with a cystic airspace. Chest CT revealed a solid tumour component arising from the wall of a pre‐existing lung cyst. This case highlights the clinical importance of recognising cystic airspaces as potential sites for aggressive malignancies like SCLC.
Hiroyuki Shimada, Yukihisa Inoue, Osamu Matsubara, Mio Yamamoto, Shohei Yamashita, Tetsu Hara, Kazuki Yamanaka, Yasuto Jinn   +7 more
wiley   +1 more source

Proteomic and metabolic signatures of female reproductive factors and risk of age‐related ocular diseases: A large prospective cohort study

VIEW, Volume 7, Issue 4, August 2026.
The full editable vector source file of this graphical abstract is uploaded as a supplementary EPS file for typesetting. All elements are copyright‐free. Abstract Age‐related ocular diseases (ARODs), including cataract, primary open‐angle glaucoma (POAG), and age‐related macular degeneration (AMD), are leading causes of vision impairment and exhibit ...
Linge Jian, Zhiqian Huang, Keke Zhang, Jing Lin, Jia You, Yi Lu, Xiangjia Zhu   +6 more
wiley   +1 more source

Multivalent antibody‐based conjugates as new tools for tailored modulation of G protein–coupled receptors

British Journal of Pharmacology, Volume 183, Issue 16, Page 4512-4531, August 2026.
The G protein–coupled receptor (GPCR) superfamily consists of the most common targets of approved drugs. Targeting GPCRs offers appealing avenues for therapeutic development. Antibodies and their fragments, such as single‐domain antibodies (VHHs or nanobodies), have emerged as useful alternatives to small molecule pharmacophores as building blocks in ...
Shivani Sachdev, Ross W. Cheloha
wiley   +1 more source

Effect of Chewing Gum on Bowel Function Recovery in Elderly Patients Following Posterior Lumbar Fusion Surgery: A Randomized Controlled Trial

Orthopaedic Surgery, Volume 18, Issue 8, Page 1641-1648, August 2026.
Chewing gum did not improve early bowel recovery after lumbar fusion. ABSTRACT Objective Given the paucity of prospective randomized evidence on chewing gum for postoperative bowel recovery in elderly spinal fusion patients, this study aimed to assess the efficacy of chewing gum in improving bowel function recovery in the elderly after posterior lumbar
Fuze Liu, Yifei Li, Gaoyang Li, Xiaoyan He, Lin Zhang, Meijia Zhang, Tian Liu, Ying Jiang, Qinlu Wang, Yaping Chen, Hai Wang   +10 more
wiley   +1 more source

Recent Patents and FDA-Approved Drugs Based on Antiviral Peptides and Other Peptide-Related Antivirals. [PDF]

Int J Pept Res Ther, 2023
Mousavi Maleki MS, Sardari S, Ghandehari Alavijeh A, Madanchi H.   +3 more
europepmc   +1 more source

Analysis of gastrin-17 and its related influencing factors in physical examination results. [PDF]

Immun Inflamm Dis, 2023
Zeng J, Shen Y, Xu S, Yang R.
europepmc   +1 more source

Effectiveness of Fuling () and its extracts against spleen deficiency in rats tonifying spleen. [PDF]

J Tradit Chin Med, 2023
Min F, Ziming J, Ming W, Bolin F, Xiaoqiao T, Wenhua C, Fanzhong S.   +6 more
europepmc   +1 more source