Results 51 to 60 of about 1,657 (182)
Evaluation of Mutation Risk Using Patient‐Derived Organoids in Patients With Lynch Syndrome
International Journal of Cancer, Volume 159, Issue 10, Page 2585-2594, 15 November 2026.ABSTRACT Lynch syndrome (LS) is a hereditary cancer predisposition syndrome caused by germline mutation of DNA mismatch repair (MMR) genes, most notably associated with colorectal cancer. Although LS patients face high risk of CRC, risk can vary even among those with the same pathogenic MMR germline mutations. We suggest a functional assay platform for
Youmi Shin +10 more
wiley +1 more source
Excretion of progastrin products in human urine
, 1999 The renal handling of carboxyamidated gastrins, NH2-terminal progastrin fragments, and glycine-extended gastrins was examined in healthy volunteers. The respective urinary clearances after a meal amounted to 0.09 ± 0.02%, 0.17 ± 0.04% ( P< 0.05), and ...
F. Stadil +3 more
core +1 more source
Studies of gastrin and gastric secretion in the horse [PDF]
, 1999 The high frequency of gastric ulcers in horses and the lack of information about the mechanisms that regulate gastric acid secretionformthe basis for this thesis.
Sandin, Andreas
core +1 more source
Spinal Mechanisms of Testosterone Involved in Itch Regulation
CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.Testosterone serves as an endogenous anti‐pruritic hormone underlying sex‐dependent itch differences. In the spinal dorsal horn, testosterone binds androgen receptors on GABAergic interneurons to enhance GABA release, suppressing GRPR+ − pruriceptive neurons through GABAA receptors and alleviating acute/chronic itch alongside itch‐comorbid anxiety ...
Luying Chen +5 more
wiley +1 more source
Comprehensive Physiology, Volume 16, Issue 5, October 2026.Obesity is associated with accelerated gastric emptying. Weight‐loss interventions each impose a distinct emptying signature: acceleration after sleeve gastrectomy and gastric bypass, delay after endoscopic sleeve gastroplasty, intragastric balloon, and GLP‐1 receptor agonists.
Maxime Amoyel +4 more
wiley +1 more source
Small, Volume 22, Issue 55, 1 October 2026.This study discriminates between sulfated and unsulfated cholecystokinin‐8 gut‐hormone forms at single‐molecule‐level resolution. Using an aerolysin nanopore embedded in a hybrid lipid‐polymer membrane, the system produces distinct electrical signatures enabling highly sensitive detection, even in 20% human serum.
Luca Iesu +3 more
wiley +1 more source
Gastrin Antibodies: Induction, Demonstration, and Specificity
, 1967 Antibodies to the antral hormone gastrin have been induced in the rabbit and detected by passive hemagglutination. Specificity of the antibody, as determined by three methods, is directed to gastrins I and II, gastrin pentapeptide, and gastrin ...
Schneider, D. R. +5 more
core +1 more source
Circulating gastrin is increased in hemochromatosis [PDF]
, 2006 Gastric acid production is important in intestinal iron absorption. The peptide hormone gastrin exists in both amidated and non-amidated forms, which stimulate and potentiate gastric acid secretion, respectively.
Kovac, Suzana +9 more
core +1 more source
Progastrin processing differs in 7B2 and PC2 knockout animals: a role for 7B2 independent of action on PC2 [PDF]
, 2002 Cellular synthesis of neuroendocrine peptides requires prohormone convertases (PCs). In order to determine the role of PC2 for gastrin synthesis, we examined antral extracts from mice lacking PC2 or its chaperone, 7B2.
Lindberg, Iris +5 more
core +1 more source
Radiolabeled gastrins in CCK2R-positive tumor targeting [PDF]
, 2016 In this thesis, several novel radiolabeled gastrin analogs were developed preclinically in vitro as well as in vivo in animal models. In addition, the effect of in situ enzyme inhibition on metabolic stability and tumor uptake of the same gastrin ...
Kaloudi, A. (Katerina)
core +1 more source