Results 61 to 70 of about 773,598 (400)

TREX1, a predator for treating MSI‐H tumors?

Molecular Oncology, EarlyView.
Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya, Joséphine Deneft, Marc Van den Eynde   +2 more
wiley   +1 more source

'How compliant do we want to be with the colonoscopy surveillance guidelines?'

, 2007
Objective: To assess the referral practice for surveillance colonoscopy amongst clinicians and to measure whether practice was inline with the current Association of Coloproctology of Great Britain and Ireland (ACPGBI) and the British Society of ...
Basnyat, P.S., Chivers, K.C., Taffinder, N.   +2 more
core   +1 more source

A dog model for acetaminophen-induced fulminant hepatic failure. [PDF]

, 1989
The development of a large animal model of fulminant hepatic failure produced with acetaminophen that should be useful in the development and evaluation of potential medical therapies for the important clinical problem of fulminant hepatic failure is ...
Barone, M, Demetris, J, Francavilla, A, Makowka, L, Polimeno, L, Prelich, J, Starzl, TE, Van Thiel, DH   +7 more
core   +1 more source

American College of Gastroenterology-Canadian Association of Gastroenterology Clinical Practice Guideline: Management of Anticoagulants and Antiplatelets During Acute Gastrointestinal Bleeding and the Periendoscopic Period

American Journal of Gastroenterology, 2022
We conducted systematic reviews of predefined clinical questions and used the Grading of Recommendations, Assessment, Development and Evaluations approach to develop recommendations for the periendoscopic management of anticoagulant and antiplatelet ...
N. Abraham, A. Barkun, B. Sauer, J. Douketis, L. Laine, Peter A. Noseworthy, J. Telford, G. Leontiadis   +7 more
semanticscholar   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Large language models: a primer and gastroenterology applications

Therapeutic Advances in Gastroenterology
Over the past year, the emergence of state-of-the-art large language models (LLMs) in tools like ChatGPT has ushered in a rapid acceleration in artificial intelligence (AI) innovation.
Omer Shahab, Bara El Kurdi, Aasma Shaukat, Girish N. Nadkarni, Ali Soroush   +4 more
semanticscholar   +1 more source

Diagnosis, Management, and Prevention of Button Battery Ingestion in Childhood: A European Society for Paediatric Gastroenterology Hepatology and Nutrition Position Paper

Journal of Pediatric Gastroenterology and Nutrition - JPGN, 2021
Supplemental Digital Content is available in the text ABSTRACT Button batteries (BB) remain a health hazard to children as ingestion might lead to life-threatening complications, especially if the battery is impacted in the esophagus.
A. Mubarak, M. Benninga, I. Broekaert, J. Dolinsek, M. Homan, E. Mas, E. Miele, C. Pienar, N. Thapar, M. Thomson, C. Tzivinikos, L. de Ridder   +11 more
semanticscholar   +1 more source

Temporal Trends in and Associations With Nonsteroidal Anti‐inflammatory Drug Prescription in Adult and Pediatric Patients With Inflammatory Bowel Disease

Arthritis Care &Research, EarlyView.
Objective Recent inflammatory bowel disease (IBD) treatment guidelines have recommended against nonsteroidal anti‐inflammatory drug (NSAID) use despite prevalent musculoskeletal symptoms and opioid overuse in this population. Given the discordance between changing national guidelines and potential clinical utility, we sought to assess national temporal
Adam S. Mayer, Rui Xiao, Andrew Grossman, Meenakshi Bewtra, Michael D. George, Pamela F. Weiss   +5 more
wiley   +1 more source

Alexithymia in Gastroenterology and Hepatology: A Systematic Review

Frontiers in Psychology, 2018
Background: Alexithymia is a multifaceted personality construct that represents a deficit in the cognitive processing of emotions and is currently understood to be related to a variety of medical and psychiatric conditions.
Danilo Carrozzino, Danilo Carrozzino, Piero Porcelli   +2 more
doaj   +1 more source

Sex Differences in the Association Between Frailty and Sarcopenia in Patients With Cirrhosis. [PDF]

, 2019
ObjectivesFrailty is prevalent in patients with cirrhosis and is hypothesized to result in part from sarcopenia, but the precise contribution of sarcopenia to frailty in this population is poorly understood.MethodsIncluded were patients with cirrhosis ...
Bhanji, Carey, Dasarathy, DiMartini, Englesbe, Fried, Kuo, Lai, Lai, Lai, Lang, Montano-Loza, Montano-Loza, Riggio, Sinclair, Tandon, Wang, Yadav   +17 more
core   +2 more sources