Results 71 to 80 of about 415,933 (291)
Tan et al. developed a platelet membrane‐coated, thermoresponsive liposome for targeted, light‐controlled delivery of fluorinated peptides that promotes programmed death‐ligand 1 degradation, induces tumor immunogenic cell death, suppresses solid tumors and metastases, and triggers durable immune memory, offering a promising strategy for peptide‐based ...
Manman Tan+19 more
wiley +1 more source
This month in Gastroenterology [PDF]
Karen E. Kim, Thomas A. Brasitus
openaire +3 more sources
ACSS2/AATF Drives Soluble FasL‐Mediated CD8+ T Cell Apoptosis in Pancreatic Neuroendocrine Tumors
This study unveils that ACSS2‐driven acetate metabolism fuels histone pan‐acetylation in pancreatic neuroendocrine tumors (PNETs), remodeling the epigenetic landscape. The ACSS2/AATF axis transcriptionally activates soluble FasL (sFasL), which engages Fas receptors on infiltrating CD8+ T cells to trigger caspase‐8/3‐mediated apoptosis.
Qin Dang+14 more
wiley +1 more source
Gastroenterology Research and Practice
doaj +1 more source
Venous thromboembolism (VTE) is a major threat to cancer patients. Cancer‐derived large extracellular vesicles deliver CYBA (p22phox) to neutrophils, triggering reactive oxygen species (ROS) and citrullinated histone H3 (citH3) formation. This drives neutrophil extracellular traps formation (NETosis), elevating VTE risk.
Xiangji Li+8 more
wiley +1 more source
Principles of rehabilitation of children with digestive pathology
Chronic diseases of the digestive system in children are one of the most prevalent diseases in pediatric pathology structure. It often causes temporary disability and invalidity in adults.
L.G. Voloshyna+3 more
doaj +1 more source
Inhibition of Tumor Lipogenesis and Growth by Peptide‐Based Targeting of SREBP Activation
A peptide that replicates the amino acid sequence in Insig1/2 loop 1 inhibits the IGF1‐induced interaction between PCK1 and Insig1/2, PCK1‐mediated phosphorylation of Insig1/2, and SREBP activity‐dependent lipid synthesis. Administration of the LNP‐Insig1/2 loop 1 peptide effectively attenuates tumor growth and sensitizes tumors to the antitumor effect
Shudi Luo+10 more
wiley +1 more source
Gastroenterology Research and Practice
doaj +1 more source