Results 81 to 90 of about 1,354,341 (319)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

A Western single-center experience with endoscopic submucosal dissection for early gastrointestinal cancers [PDF]

, 2010
06/03/14 meb. Accepted author manuscript, OK to add.Endoscopic Submucosal Dissection (ESD) has gained worldwide acceptance as a treatment for Early Gastrointestinal Cancers (EGICs).
Coda, Sergio, Takuji Gotoda, d'Amati, Giulia, Negro, Paolo, Trentino, Paolo, Franco Ruberto, Barbara Porowska, Porowska, Barbara, Paolo Negro, Francesco Gossetti, Ruberto, Franco, Sergio Coda, Pugliese, Francesco, Fabio Antonellis, Giulia d’Amati, Gossetti, Francesco, Francesco Pugliese, Antonellis, Fabio, Gotoda, Takuji, Paolo Trentino   +19 more
core   +1 more source

Roles of healthcare professionals in the management of chronic gastrointestinal diseases with a focus on primary care: A systematic review

JGH Open, 2020
Background and aim Inflammatory bowel disease (IBD) refers to a group of complex and chronic conditions that requires long‐term care delivered by a group of healthcare professionals through a multidisciplinary care model. We conducted a systematic review
Sharmila S Prasad, Michael Potter, Simon Keely, Nicholas J Talley, Marjorie M Walker, Therése Kairuz   +5 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Metabolomic applications to decipher gut microbial metabolic influence in health and disease

Frontiers in Physiology, 2012
Dietary preferences and nutrients composition have been shown to influence human and gut microbial metabolism, which ultimately has specific effects on health and diseases’ risk.
Francois-Pierre eMartin, Sebastiano eCollino, Serge eRezzi, Sunil eKochhar   +3 more
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Gastrointestinal mucormycosis

Journal of British Surgery, 1991
Abstract Twenty patients with gastrointestinal mucormycosis are reviewed. This often fatal opportunistic fungal infection was diagnosed histologically, and was categorized as colonization (five patients), infiltration (seven patients), or vascular invasion (eight patients). There were no fatalities from colonization.
S R, Thomson, P G, Bade, M, Taams, V, Chrystal   +3 more
openaire   +2 more sources

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Analysis of volatile marker compounds in body fluid samples from patients with gastrointestinal disease [PDF]

, 2010
Causes of gastrointestinal diseases such as ulcerative colitis (UC) Crohn’s disease (CD) and irritable bowel syndrome (IBS) are not yet completely understood and clinical investigation for diagnosis is invasive, costly and time consuming.
Fowler, Dawn P.
core  

Eastern Canadian Gastrointestinal Cancer Consensus Conference 2024 [PDF]

The Eastern Canadian Gastrointestinal Cancer Consensus Conference was an annual meeting that was held in St. John’s, Newfoundland and Labrador, from 26 to 28 September 2024.
David T. Laidley, Brooke Wilson, Rachel Goodwin, Shaan Dudani, Arwa Ahmed, Marie-Pierre Campeau, Jessica Corbett, Luisa Galvis, Aamer Mahmud, Francine Aubin, Conrad Falkson, Setareh Samimi, Melanie Boucher, Elena Elimova, Scott Berry, Timothy Asmis, Thais Baccili Cury Megid, Shivani Dadwal, Rakesh Goel, Gordon Locke, Vimoj J. Nair, Melanie Seal, Michael Vickers, Joanna Gotfrit, Silvana Spadafora, James Michael, Jennifer Leigh, Stephen Quigley, Stacie Connors, Angela Hyde, Teri Stuckless, Michela Febbraro, Ravi Ramjeesingh, Stephanie Snow, Bruce Colwell   +34 more
core   +1 more source