Results 71 to 80 of about 4,823,404 (316)

PPARs and Gastrointestinal Cancer [PDF]

PPAR Research, 2012
Since the discovery of the peroxisome proliferator-activated receptors (PPARs) in Xenopus frogs as receptors that induce the proliferation of peroxisomes in cells, the study of these factors has received widespread interest. After the characterization of the different isoforms (PPARα, PPARβ/δ, and PPARγ) of these nuclear receptors in the 90s, numerous ...
openaire   +3 more sources

Combination of Immunotherapy and Radiation Therapy in Gastrointestinal Cancers: An Appraisal of the Current Literature and Ongoing Research

, 2023
Oncological outcomes are improving in gastrointestinal cancer with advancements in systemic therapies, and there is notable potential in combining immunotherapy and radiation therapy (RT) to allow for further improvements.
Haejin In, Jongmyung Kim, Russell C. Langan, Lyudmyla Berim, Timothy Kennedy, Mihir M. Shah, Ritesh Kumar, Salma K. Jabbour, Prateek Gulhati, Mariam F. Eskander, Howard S. Hochster, Patrick M. Boland, Miral S. Grandhi, Kristen R. Spencer, Matthew P. Deek   +14 more
core   +1 more source

Clinical Practice Guideline for Endoscopic Resection of Early Gastrointestinal Cancer [PDF]

, 2020
Although surgery was the standard treatment for early gastrointestinal cancers, endoscopic resection is now a standard treatment for early gastrointestinal cancers without regional lymph node metastasis.
Dong-Hoon Yang, Dong-Ah Park, Bae, Jung Ho, Lee, Jong Yeul, Jun Chul Park, Park, Chan Guk, Lee, Hyun Jung, Bun Kim, Park, Jun Chul, Soo Teik Lee, Kim, Jong Wook, Lee, Si Hyung, Ji Hyun Kim, Kim, Ji Hyun, Byeon, Jeong-Sik, Lee, Hyuk, Park, Dong-Ah, Hyuk Lee, Jung Ho Bae, Si Hyung Lee, Hye Seung Lee, Jong Wook Kim, Kee Don Choi, Jeong-Sik Byeon, Choi, Miyoung, Jong Yeul Lee, Park, Chan Hyuk, Kwak, Min-Seob, Yang Won Min, Hyunsoo Chung, Choi, Kee Don, Yang, Dong-Hoon, Lee, Hye Seung, Lee, Soo Teik, Hoon Jai Chun, Min, Yang Won, Jie-Hyun Kim, Chun, Hoon Jai, Hyun Jung Lee, Miyoung Choi, Joo Young Cho, Min-Seob Kwak, Cho, Joo Young, Kim, Bun, Chan Hyuk Park, Kim, Jie-Hyun, Chung, Hyunsoo, Chan Guk Park   +47 more
core   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Real-world data of anamorelin in advanced gastrointestinal cancer patients with cancer cachexia

BMC Palliative Care
Background Cancer cachexia is characterized by the loss of body weight (BW) and anorexia. Anamorelin (ANAM) is a selective ghrelin receptor agonist with appetite-enhancing anabolic action.
Ari Nishimura, Satoshi Hamauchi, Akifumi Notsu, Kunihiro Fushiki, Kotoe Oshima, Takahiro Tsushima, Takeshi Kawakami, Akiko Todaka, Tomoya Yokota, Hirofumi Yasui, Yusuke Onozawa, Kentaro Yamazaki   +11 more
doaj   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Cowden syndrome - Diagnostic skin signs [PDF]

, 2001
Cowden syndrome is a rare autosomal dominant familial cancer syndrome with a high risk of breast cancer. The most important clinical features include carcinomas of the breast and thyroid, and hamartomatous polyps of the gastrointestinal tract.
Burgdorf, Walter H. C., Hildenbrand, C., Lautenschlager, Stephan, S. Lautenschlager, C. Hildenbrand, W.H.C. Burgdorf   +5 more
core   +1 more source

The multifaceted roles of lysosomes in cancer

Molecular Oncology, EarlyView.
Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley   +1 more source

Impact of electrosurgical unit mode on post esophageal endoscopic submucosal dissection stricture in an in vivo porcine model

Endoscopy International Open, 2018
Background and aim Strictures are a major complication of esophageal endoscopic submucosal dissection (ESD) for superficial esophageal carcinoma. Post ESD, stricture develops during the process of scar formation, which is related to inflammation caused ...
Yusuke Tonai, Ryu Ishihara, Yasushi Yamasaki, Masamichi Arao, Taro Iwatsubo, Minoru Kato, Syo Suzuki, Kenta Hamada, Satoki Shichijo, Noriko Matsuura, Takashi Kanesaka, Hiroko Nakahira, Sachiko Yamamoto, Tomofumi Akasaka, Noboru Hanaoka, Yoji Takeuchi, Koji Higashino, Noriya Uedo, Yasuhiko Tomita, Hiroyasu Iishi   +19 more
doaj   +1 more source