Results 91 to 100 of about 96,065 (282)

7‐Ketodeoxycholic Acid Promotes Colonic Mucosal Healing by Inducing Calcium Release from Endoplasmic Reticulum via the TGR5‐IP3R Pathway

Advanced Science, EarlyView.
7‐KDCA functions by driving intestinal epithelial cell migration through induction of calcium release from the endoplasmic reticulum. The findings emphasize a previously unrecognized property of 7‐KDCA in regulating cell migration, a required process for effective epithelial restitution and repair that is particularly critical for patients with UC to ...
Jing Zhang, Feng Jiang, Wenxin Xia, Yilei Guo, Yanrong Zhu, Mianjiang Zhao, Lingzi Xiao, Zhifeng Wei, Yufeng Xia, Yue Dai   +9 more
wiley   +1 more source

Polydopamine Nanodots Ameliorate Inflammatory Bowel Disease by Restoring Redox Homeostasis and Intestinal Microenvironment

Advanced Science, EarlyView.
A novel melanin‐based therapeutic composed of ultrasmall polydopamine nanodots is employed as an efficient oral formulation for the targeted treatment of inflammatory bowel disease. The potential therapeutic mechanism of polydopamine nanodots mainly involves the elimination of excessive oxidative stress, the reduction of ROS‐mediated proinflammatory ...
Zhen Ding, Xingfu Bao, Ying Zhao, Lin Bai, Jinming Zhang, Chengjing Xu, Tianyan Chen, Shuang Dai, Yufu Liu, Min Hu, Meng Qin, Zhen Liu   +11 more
wiley   +1 more source

The gastrointestinal microbiome: a malleable, third genome of mammals [PDF]

, 2009
Ian M. Carroll, David W. Threadgill, David W. Threadgill   +2 more
openalex   +1 more source

A healthy gastrointestinal microbiome is dependent on dietary diversity

Molecular Metabolism, 2016
Like all healthy ecosystems, richness of microbiota species characterizes the GI microbiome in healthy individuals. Conversely, a loss in species diversity is a common finding in several disease states. This biome is flooded with energy in the form of undigested and partially digested foods, and in some cases drugs and dietary supplements.
Heiman, Mark L., Greenway, Frank L.
openaire   +4 more sources

Faecalibaculum rodentium Alleviates Ionizing Radiation‐Induced Damage in Mice by Improving Intestinal Integrity and Hematopoiesis via Its Metabolite Butyrate

Advanced Science, EarlyView.
The model shows the probiotics screening and underlying mechanisms of F. rodentiumn in alleviating IR‐induced tissue injury. Stress‐induced STAT3 mitochondria localization decreases F. rodentium abundance and butyrate concentration. Supplementation of F.
Hanyong Zhu, Hui Guo, Na Sun, Rui Xiao, Binbin Ji, Ruihan Jiang, Fuxing Dong, Chen Yao, Xuerong Wang, Rongqing Li, Jie Zhao, Xueqin Li, Shengzhe Gong, Yongqin Qin, Xin Chen, Yuchen Pan, Takayuki Ikezoe, Jing Yang   +17 more
wiley   +1 more source

An Effective Oral Drug Delivery Route for Pharmacokinetic Complications: Spirulina Lipid Nanotechnology System

Advanced Science, EarlyView.
Spirulina‐nano system facilitates the formation of drug coating on spirulina's surface through electrostatic adsorption. It targets intestinal villi effectively and overcomes the pharmacokinetic complications of IBS‐D. This system successfully carried out the treatment of multiple symptoms, including diarrhea, visceral hypersensitivity, mental symptoms,
Jiahui Ye, Xinyi Wu, Jin Liu, Yongmi Guo, Chong Ji, Zhouyue Wang, Di Yang, Min Zhou   +7 more
wiley   +1 more source

Aging as a Loss of Goal‐Directedness: An Evolutionary Simulation and Analysis Unifying Regeneration with Anatomical Rejuvenation

Advanced Science, EarlyView.
The paper proposes that the root cause of aging is the loss of anatomical goal‐directedness after development. Using evolutionary neural cellular automata simulations, the authors show that after the organism has reached its developmental homeostatic setpoint (the adult morphology), the absence of target state to pursue leads to a drifting anatomical ...
Léo Pio‐Lopez, Benedikt Hartl, Michael Levin   +2 more
wiley   +1 more source

Integrated Metabolic and Inflammatory Clustering Reveals Distinct Risk Profiles for Digestive Diseases

Advanced Science, EarlyView.
This study analyzes 398 432 participants, identifying four distinct metabolic‐inflammatory subtypes. These subtypes show a significant association with digestive disease risk. Cluster‐associated metabolite signatures partially explain this link. Machine learning models using these metabolites accurately predict risk for ten digestive diseases. Key risk
Zhenhe Jin, Qichen Chen, Liangfeng Zhou, Kexin Ye, Zhaoxue Liu, Wenxi Jiang, Linwen Luo, Yize Wang, Xiaohua Ye, Chaohui Yu, Zhe Shen   +10 more
wiley   +1 more source

Photobiomodulation Strengthens Muscles via Its Dual Functions in Gut Microbiota

Advanced Science, EarlyView.
Non‐invasive photobiomodulation therapy (PBMT) enhances muscle endurance by rewiring the gut‐muscle axis. PBMT preserves gut epithelial integrity and enriches beneficial anaerobes, driving metabolites such as butyrate, spermidine, and L‐carnitine that supercharge mitochondrial energy in skeletal muscles.
Prabhat Upadhyay, Asmita Banstola, Brijesh Bhayana, Mei X. Wu   +3 more
wiley   +1 more source

Gut health predictive indices linking gut microbiota dysbiosis with healthy state, mild gut discomfort, and inflammatory bowel disease phenotypes using gut microbiome profiling

Microbiology Spectrum
Despite the complexity of the gut microbiome, several scores that use taxonomic characteristics exist that attempt to identify a healthy gut or gastrointestinal disease.
Joann Phan, Suneer Jain, Jurgen F. Nijkamp, Rajkumar Sasidharan, Ashish Agarwal, Julia K. Bird, Anneleen Spooren, Jonas Wittwer Schegg, Emiel Ver Loren van Themaat, Tim N. Mak   +9 more
doaj   +1 more source