Altered microbiota and impaired host immune function have been linked to the pathogenesis of pouchitis. We used 16S rRNA gene sequencing and RNA sequencing data from a previous randomized clinical trial (RCT) on fecal microbiota transplantation (FMT ...
Anna K. Hartikainen+7 more
doaj +1 more source
Research gaps in diet and nutrition in inflammatory bowel disease. A topical review by D-ECCO Working Group (Dietitians of ECCO) [PDF]
Although the current doctrine of IBD pathogenesis proposes an interaction between environmental factors with gut microbiota in genetically-susceptible individuals, dietary exposures have attracted recent interest and are, at least in part, likely to ...
Allan, Philip+14 more
core +4 more sources
Systemic sclerosis is associated with specific alterations in gastrointestinal microbiota in two independent cohorts. [PDF]
ObjectiveTo compare faecal microbial composition in patients with systemic sclerosis (SSc) from 2 independent cohorts with controls and to determine whether certain genera are associated with SSc-gastrointestinal tract (GIT) symptoms.DesignAdult patients
Braun, Jonathan+14 more
core +1 more source
A generalized Bayesian stochastic block model for microbiome community detection [PDF]
Advances in next-generation sequencing technology have enabled the high-throughput profiling of metagenomes and accelerated the microbiome study. Recently, there has been a rise in quantitative studies that aim to decipher the microbiome co-occurrence network and its underlying community structure based on metagenomic sequence data.
arxiv
From metagenomics to the metagenome: Conceptual change and the rhetoric of translational genomic research [PDF]
As the international genomic research community moves from the tool-making efforts of the Human Genome Project into biomedical applications of those tools, new metaphors are being suggested as useful to understanding how our genes work – and for ...
Huss, John Edward, Juengst, Eric Thomas
core +1 more source
Lumen and mucosa-associated Lactobacillus rhamnosus from the intestinal tract of organ donors
Knowledge of the intra-individual spatial and regional distribution of intestinal microbial populations is essential to understand gut host–microbial interactions.
Alan J. Marsh+6 more
doaj +1 more source
The Brain-Gut-Microbiome Axis. [PDF]
Preclinical and clinical studies have shown bidirectional interactions within the brain-gut-microbiome axis. Gut microbes communicate to the central nervous system through at least 3 parallel and interacting channels involving nervous, endocrine, and ...
Kalani, Amir+3 more
core +2 more sources
Microbiome Intervention Analysis with Transfer Functions and Mirror Statistics [PDF]
Microbiome interventions provide valuable data about microbial ecosystem structure and dynamics. Despite their ubiquity in microbiome research, few rigorous data analysis approaches are available. In this study, we extend transfer function-based intervention analysis to the microbiome setting, drawing from advances in statistical learning and selective
arxiv
Microbiome and its impact on gastrointestinal atopy [PDF]
AbstractThe prevalence of allergic conditions has continuously increased in the last few decades in Westernized countries. A dysbiotic gut microbiome may play an important role in the development of allergic diseases. Genetic, environmental, and dietary factors may alter the commensal microbiota leading to inflammatory dysregulation of homeostasis ...
Jonathan M. Spergel+7 more
openaire +3 more sources
Rough Set Microbiome Characterisation [PDF]
Microbiota profiles measure the structure of microbial communities in a defined environment (known as microbiomes). In the past decade, microbiome research has focused on health applications as a result of which the gut microbiome has been implicated in the development of a broad range of diseases such as obesity, inflammatory bowel disease, and major ...
arxiv