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Gastrointestinal stromal tumor of the rectum
European Radiology, 2001Gastrointestinal stromal tumors (GISTs) are characterized by remarkable variability in their differentiation potential, but most of these lesions do not display convincing smooth muscle or neuronal differentiation. The GISTs arising from the rectum or anal canal are extremely uncommon.
Y, Hama +4 more
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Gastrointestinal Stromal Tumors
Current Oncology ReportsThis review aims to outline the current understanding of the molecular drivers and treatment paradigms of gastrointestinal stromal tumors, with a focus on recent developments in treatment in the advanced disease setting.There have been recent advancements in our understanding of the molecular biology of gastrointestinal stromal tumors, including the ...
Gal, Strauss, Suzanne, George
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GASTROINTESTINAL STROMAL TUMOR
2010Gastrointestinal stromal tumor, i.e., GIST is by far the most common mesenchymal tumor of the gastrointestinal tract. GIST has received special clinical attention, because it is one of the first solid tumors treated with tyrosine kinase inhibitors as targeted oncological therapy.
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Gastrointestinal stromal tumors
Current Treatment Options in Oncology, 2000The nonepithelial, nonlymphoid tumors of the gastrointestinal tract are heterogeneous in terms of clinical presentation, behavior, pathology, and genetic features. Concepts regarding these tumors have changed rapidly over the past decade as nomenclature has evolved. Many of these tumors have no muscle differentiation, and designations such as leiomyoma
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Gastrointestinal Stromal Tumors and Neuroendocrine Tumors
Seminars in Oncology Nursing, 2009Patients with rare gastrointestinal (GI) malignancies can exhibit unique objective and subjective manifestations. This article is a primer for the fundamental understanding of some of these diseases, namely gastrointestinal stromal tumors (GIST) and gastroenteropancreatic neuroendocrine tumors (NET) and therapeutic strategies.Epidemiologic data ...
Carolyn, Grande, Daniel G, Haller
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Regorafenib in Gastrointestinal Stromal Tumors
Future Oncology, 2014Gastrointestinal stromal tumors (GIST) are the most common mesenchymal tumors of the GI tract and constitute less than 1% of all digestive tract tumors--the stomach is the most common site. Regorafenib is a multi-tyrosine kinase inhibitor with regulatory approvals granted for colorectal cancers and GIST.
Bhawna, Sirohi +2 more
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Management of Gastrointestinal Stromal Tumors
Surgical Clinics of North America, 2008A gastrointestinal stromal tumor (GIST) is a rare mesenchymal malignancy of the gastrointestinal (GI) tract. Malignant GISTs were first defined as a separate entity from a collection of nonepithelial malignancies of the GI tract in the 1980s and 1990s based on pathologic and clinical behavior. The discovery of activating KIT mutations as a near-uniform
Matthew T, Hueman, Richard D, Schulick
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Colorectal gastrointestinal stromal tumor
Techniques in Coloproctology, 2010Gastrointestinal stromal tumor (GIST) is the most common mesenchymal neoplasm arising in the digestive tract, with an estimated prevalence of 15-20 per 1,000,000. GISTs are related to the interstitial cells of Cajal and are characterized by constitutive over-expression of the transmembrane tyrosine kinase receptor KIT.
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Pediatric Gastrointestinal Stromal Tumor
Journal of Pediatric Gastroenterology and Nutrition, 2023Łukasz Dembiński +3 more
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Gastrointestinal stromal tumor of the rectum
The American Journal of the Medical Sciences, 2023Ami, Schattner +3 more
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