Results 251 to 260 of about 87,116 (304)

Immunotherapy in gastrointestinal stromal tumors: Current landscape and future horizons. [PDF]

World J Clin Oncol
Papadakos SP, Argyrou A, Karniadakis I, Vogli S, Theocharis S.   +4 more
europepmc   +1 more source

DRD2 Deficiency Underlies Pituitary Adenoma Dependent on Escherichia coli Translocation from the Gut

Advanced Science, Volume 13, Issue 24, 27 April 2026.
Dopamine receptor D2 (DRD2) deficiency disrupts epithelial barrier integrity in both the gut and pituitary gland, facilitating translocation of gut‐derived Escherichia coli into pituitary tissue. Intratumoral E. coli are phagocytosed by microglia, triggering GSDMD‐dependent pyroptosis and HMGB1 release, which subsequently activates MAPK signaling to ...
Xian‐jun Su, Li Ma, Xi Xiong, Jun‐hua Meng, Qi Wu, Yu Zhang, Shu‐guang Dong, Yue‐fei Wang, Jin‐hu Wu, Qing‐yuan Zeng, Hong‐feng Zhang, Li‐li Li, Liang Meng, Min Peng, Xiao‐dong Huang, Li‐quan Wu, Xiong Wang   +16 more
wiley   +1 more source

A CT-based decision tree model for differentiating sub-3 cm gastric ectopic pancreas from gastrointestinal stromal tumors. [PDF]

BMC Gastroenterol
Duan J, Zhao Y, Shi Q, Wang Y, Huang X, Rao Q, Fan S, Xu J.   +7 more
europepmc   +1 more source

Patient‐Derived 3D‐Bioprinted Intrahepatic Cholangiocarcinoma Models Recapitulate Tumor Autologous Traits and Predict Personalized Adjuvant Therapy

Advanced Science, Volume 13, Issue 22, 17 April 2026.
Leveraging 3D bioprinting, this study establishes patient‐derived in vitro models of intrahepatic cholangiocarcinoma. These models faithfully recapitulate the histopathology, molecular profiles, and genomic characteristics of the original patient tumors.
Yuce Lu, Liwei Du, Minghao Sun, Kai Zhang, Mingchang Pang, Shangze Jiang, Jiaxun Dong, Xiyue Liu, Bao Jin, Fu Xu, Hang Sun, Jiangang Zhang, Huiyu Yang, Xiaobo Yang, Xin Lu, Yiyao Xu, Haitao Zhao, Shunda Du, Xinting Sang, Yongchang Zheng, Lei Zhang, Xueshuai Wan, Huayu Yang, Yilei Mao   +23 more
wiley   +1 more source

<i>FGFR2</i> fusions as novel oncogenic drivers in gastrointestinal stromal tumors: Two case reports and review of literature. [PDF]

World J Gastrointest Oncol
Hong YY, Shou CH, Yang WL, Wang XD, Zhang Q, Liu XS, Yu JR.   +6 more
europepmc   +1 more source

Integrating Human Intestinal Organoids into FDA's New Approach Methodologies for Drug Discovery

Advanced Science, Volume 13, Issue 20, 9 April 2026.
Illustration summarizes how human intestinal organoids (HIOs) are becoming transformative in preclinical research. Preclinical drug discovery pipelines often rely on animal models for ADMET studies, even though interspecies ADME gaps, poor external validity, and high attrition rates are common.
Debarun Patra, Ibrahim M. Sayed, Souhrid Mukherjee, Honit Piplani, Aida Habtezion, Michael J. Rosen, Jospeh C. Wu   +6 more
wiley   +1 more source

Small Bowel Gastrointestinal Stromal Tumors: A 15-Year Cohort Study Focusing on Jejuno-Ileal Site-Specific Outcomes and Prognostic Factors. [PDF]

Cancers (Basel)
Kojima Y, Tominaga K, Kawata Y, Kaneko C, Kondo S, Shimada Y, Yokoyama J, Wakai T, Terai S.   +8 more
europepmc   +1 more source

FomA‐Containing Outer Membrane Vesicles of Fusobacterium Nucleatum Facilitate Bladder Cancer Lymphatic Metastasis via IL‐6‐Dependent M2b Macrophage Polarization

Advanced Science, Volume 13, Issue 23, 23 April 2026.
Urinary Fusobacterium nucleatum–derived outer membrane vesicles are shown to promote bladder cancer lymphatic metastasis. The vesicle protein FomA activates TLR2/NF‐κB signaling in tumor cells, induces IL‐6 secretion, and drives M2b macrophage polarization and VEGF‐C–dependent lymphangiogenesis, revealing a microbiota‐driven mechanism linking tumor ...
Wentai Shangguan, Weijia Li, Wenxue Huang, Jilin Wu, Yao Yu, Yiyao Huang, Lin Yang, Ming Xie, Qishen Yang, Jun Zheng, Yuexuan Zhu, Qi Sun, Biao Li, Leqian Li, Zongwei Wang, Jie Zhao, Peng Wu, Bisheng Cheng   +17 more
wiley   +1 more source

Correlation of ultrasonic characteristics, clinicopathological features, and biological risk classification in gastric gastrointestinal stromal tumors and construction of a preoperative prediction model: a feasibility study. [PDF]

Quant Imaging Med Surg
Li Y, Cui L, Tan B, Lin J, Lu M, Liu C.
europepmc   +1 more source

An update on gastrointestinal stromal tumors (GISTs) with a focus on extragastrointestinal stromal tumors (EGISTs). [PDF]

Gastroenterol Rep (Oxf)
Usama F, Rasikh R, Hassam K, Rahman M, Khalil Ur Rehman F, Khan IW, Lau DT.   +6 more
europepmc   +1 more source