Results 31 to 40 of about 63,208 (240)
Advanced Science, EarlyView.This study develops a deep learning‐based pathomics model to predict survival outcomes in pancreatic cancer patients. The CrossFormer architecture analyzes routine H&E‐stained tissue slides, identifying key prognostic features including stromal patterns, cellular characteristics, and immune infiltration.
Qiangda Chen +22 more
wiley +1 more source
Advanced Science, EarlyView.A comprehensive technology platform enables high‐fidelity, volumetric MALDI imaging of 3D cell cultures by integrating custom embedding molds, a semi‐automated computational framework for 3D reconstruction, voxel‐instead of pixel‐based biomarker discovery, and immersive mixed reality data exploration.
Stefania Alexandra Iakab +16 more
wiley +1 more source
Advanced Science, EarlyView.ABSTRACT Organoid research offers valuable insights into human biology and disease, but reproducibility and scalability remain significant challenges, particularly for epithelial organoids. Here, we present an integrated microfluidic platform that addresses these limitations by enabling high‐throughput generation of uniform hydrogel microparticles ...
Barbora Lavickova +8 more
wiley +1 more source
GOT1 Inhibition Induces Extracellular Matrix Remodeling in Pancreatic Cancer
Advanced Science, EarlyView.Using tumor tissue engineering, we recreated pancreatic cancer and found that inhibiting glutamic‐oxaloacetic transaminase 1 (GOT1) induces extracellular matrix remodeling and secretome rewiring, as well as promotes cell death. ABSTRACT Pancreatic cancer cells rely on glutamine to sustain their survival in the stiff and poorly vascularized tumor ...
Rodrigo Curvello +10 more
wiley +1 more source
GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy
Advanced Science, EarlyView.Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu +11 more
wiley +1 more source
Diagnosis of a Gastrointestinal Stromal Tumor With Spontaneous Rupture [PDF]
, 2023 Ryan Meader, Assad Munis, Dean Silas
openalex +1 more source
GIST: gastrointestinal stromal tumors.
Acta Médica Portuguesa, 2012 GIST (Gastrointestinal stromal tumors) are rare tumors of mesenchymal origin. The authors present a case of GIST in a 80 years old female with multiple co-morbilities, admitted with epigastric pain, gastrointestinal bleeding and heart failure decompensation.
Sara Uria +2 more
openaire +3 more sources
Advanced Science, EarlyView.Magnetoelectric nanoparticles (MENPs) serve as externally controlled, MRI‐activated theranostic agents for targeted cancer therapy by inducing electric field‐based ablation in solid tumors. MENPs enable simultaneous precise tumor ablation and MRI signal modulation, allowing real‐time treatment monitoring and prediction of therapeutic outcomes with no ...
John Michael Bryant +28 more
wiley +1 more source
Gastrointestinal Stromal Tumor
Jurnal Radiologi Indonesia, 2016 The gastrointestnal stromal tumor (GIST) is a gastrointestnal tract tumor, previously known as the group of smooth muscle tumors. By using medical technology improvement, GIST is shown as nonepitelial tumor that can arise along gastrointestnal tract. A patent with gastric disorder had been hospitalized multple tmes is reported.
Subodh Varshney, Ajit Sewkani
openaire +3 more sources