Results 41 to 50 of about 56,454 (256)

AIF1+CSF1R+ MSCs, induced by TNF‐α, act to generate an inflammatory microenvironment and promote hepatocarcinogenesis

Hepatology, EarlyView., 2022
Mesenchymal stem cells subset, educated by TNF‐α, are involved to generate inflammatory microenvironment and promote hepatocarcinogenesis Abstract Background and Aims Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in the liver.
Chen Zong, Yan Meng, Fei Ye, Xue Yang, Rong Li, Jinghua Jiang, Qiudong Zhao, Lu Gao, Zhipeng Han, Lixin Wei   +9 more
wiley   +1 more source

Exploring nanotechnology solutions for improved outcomes in gastrointestinal stromal tumors

Heliyon
Objectives: Gastrointestinal stromal tumors, the most prevalent mesenchymal tumors (80 %) of the gastrointestinal tract, comprise less than 1 % of all gastrointestinal neoplasms and about 5 % of all sarcomas.
Sofia Gabellone, Silvia Vanni, Valentina Fausti, Giacomo Miserocchi, Chiara Liverani, Chiara Spadazzi, Claudia Cocchi, Chiara Calabrese, Davide Cavaliere, Carlo Alberto Pacilio, Giorgio Ercolani, Federica Pieri, Lorena Gurrieri, Nada Riva, Robin Jones, Alessandro De Vita   +15 more
doaj   +1 more source

PET-Negative Gastrointestinal Stromal Tumors

Case Reports in Oncology, 2013
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal malignancy of the gastrointestinal tract. PET/CT is a common diagnostic tool and is also used for therapy monitoring. GISTs typically show strong 18F-fluorodeoxyglucose (FDG) uptake.
Anja Williams, Andreas Gutzeit, Michael Germer, Miklos Pless   +3 more
doaj   +1 more source

Synchronous Acromegaly and Gastrointestinal Stromal Tumor: A Case Report

Endocrinology Research and Practice, 2014
Acromegaly is a rare endocrine disorder characterized by the manifestations of sustained hypersecretion of growth hormone and concomitant elevations in circulating concentrations of insulin-like growth factor-1.
Hüsniye Başer, Kemal Arslan, İlknur Küçükosmanoğlu, Salih Başer, Korhan Kollu, Kemal Kalkan, Samil Ecirli   +6 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Gastrointestinal stromal tumors with pseudocystic change mimicking a pancreatic tumor: two case reports

Journal of Medical Case Reports, 2009
Introduction Cystic lesions of the upper abdomen normally develop from pancreatic tissue. The differential diagnoses include neoplastic and non-neoplastic lesions.
Pauser Ursula, Hinz Sebastian, Merz Hartmut, Feller Alfred C   +3 more
doaj   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Application of Computer-Assisted Endoscopic Ultrasonography Based on Texture Features in Differentiating Gastrointestinal Stromal Tumors from Benign Gastric Mesenchymal Tumors

The Turkish Journal of Gastroenterology
Background/Aims: Gastrointestinal stromal tumors are common gastric mesenchymal tumors that are potentially malignant. However, endoscopic ultrasonography is poor in diagnosing gastrointestinal stromal tumors.
Chengqian Lv, Hongliang Chen, Ping Huang, Yongfang Chen, Bingrong Liu   +4 more
doaj   +1 more source

Anagrelide for Gastrointestinal Stromal Tumor [PDF]

Clinical Cancer Research, 2019
Abstract Purpose: Gastrointestinal stromal tumor (GIST) is a common type of soft-tissue sarcoma. Imatinib, an inhibitor of KIT, platelet-derived growth factor receptor alpha (PDGFRA), and a few other tyrosine kinases, is highly effective for GIST, but advanced GISTs frequently progress on ...
Cervera Alejandra, Murumägi Astrid, Kulesskiy Evgeny, Sihto Harri, Joensuu Heikki, Mpindi John-Patrick, Icay Katherine, Wennerberg Krister, Varjosalo Markku, Kallioniemi Olli, Tynninen Olli, Pulkka Olli-Pekka, Laakkonen Pirjo, Lehtonen Rainer, Keskitalo Salla, Hautaniemi Sampsa, Cervera Alejandra, Murumägi Astrid, Kulesskiy Evgeny, Sihto Harri, Joensuu Heikki, Mpindi John-Patrick, Icay Katherine, Wennerberg Krister, Varjosalo Markku, Kallioniemi Olli, Tynninen Olli, Pulkka Olli-Pekka, Laakkonen Pirjo, Lehtonen Rainer, Keskitalo Salla, Hautaniemi Sampsa   +31 more
openaire   +3 more sources

Tissue‐Agnostic Cellular Morphometric Biomarkers for Risk‐Adapted Management Across Gastrointestinal Precancerous Lesions and Cancers

Advanced Science, EarlyView.
An interpretable, unsupervised artificial intelligence framework identifies a 13‐cellular morphometric biomarker (CMB) signature from routine H&E whole‐slide images. Validated across 2,602 patients, the fixed signature generalizes across colorectal, gastric, and esophageal tissues without retraining, stratifies prognosis and precancerous lesion risk ...
Pin Wang, Chengfei Jiang, April W. Mao, Qi Sun, Yijun Lu, Jingjing Wei, Jamie L. Inman, Susan E. Celniker, Antoine M. Snijders, David W. Threadgill, Allan Balmain, Bo Hang, Hang Chang, Lei Wang, Jian‐Hua Mao   +14 more
wiley   +1 more source