Results 51 to 60 of about 54,012 (256)

Study of gastrointestinal stromal tumors with c-kit immunostaining

Journal of Pathology of Nepal, 2011
Background: Mutation of the C-KIT oncogene is the central event in gastrointestinal stromal tumors which are the most common mesenchymal tumors arising from the tubular gastrointestinal tract.
B Sigdel, S Vaidya, Sabira KC
doaj   +1 more source

Ghrelin and gastrointestinal stromal tumors

World Journal of Gastroenterology, 2017
Ghrelin, as a kind of multifunctional protein polypeptide, is mainly produced in the fundus of the stomach and can promote occurrence and development of many tumors, including gastrointestinal tumors, which has been proved by the relevant researches.
Zhu, Chang-Zhen, Liu, Dong, Kang, Wei-Ming, Yu, Jian-Chun, Ma, Zhi-Qiang, Ye, Xin, Li, Kang   +6 more
openaire   +2 more sources

Optimized Ex Vivo Human Liver Slice Culture Maintains Extended Viability and Function for Hepatotoxicity Testing

Advanced Science, EarlyView.
An optimized ex vivo human liver slice culture system preserves tissue architecture, hepatocyte function, and immune‐stromal complexity for at least five days. By refining slice thickness, oxygenation, air‐liquid interface, and extracellular matrix support, the platform enables human‐relevant hepatotoxicity testing and mechanistic studies, offering a ...
Huiche Feng, Cinzia Esposito, Andrej Benjak, Matthias S. Matter, Miriam Cieri, Camilla De Carlo, Philipp Sedlaczek, Fabian Haak, Mattia Marinucci, Gabriel Fridolin Hess, Otto Kollmar, Mairene Coto‐Llerena, Luca Di Tommaso, Visar Vela, Lukas Bubendorf, Luigi M. Terracciano, Charlotte K. Y. Ng, Salvatore Piscuoglio   +17 more
wiley   +1 more source

Radiomics in the differential diagnosis of gastrointestinal stromal tumors and leiomyomas. A literature review [PDF]

Digital Diagnostics
. BACKGROUND: A limited number of studies have been conducted in Russian and world literature on the differential diagnosis of gastrointestinal stromal tumors with other intra-abdominal tumors.
Elina A. Martirosyan, Grigory G. Karmazanovsky, Evgeniy V. Kondratyev, Elena A. Sokolova   +3 more
doaj   +1 more source

Imatinib-Resistant Gastrointestinal Stromal Tumor Presenting as a Large Abdominal Mass

Case Reports in Gastroenterology, 2021
Gastrointestinal stromal tumors (GISTs) are the stromal or mesenchymal neoplasms affecting the gastrointestinal tract. Although they constitute 1% of primary gastrointestinal tumors, they are the most common nonepithelial tumors involving the ...
Asim Haider, Shehriyar Mehershahi, Ayesha Siddiqa, Madhav Sharma, Harish Patel   +4 more
doaj   +1 more source

Gastrointestinal stromal tumors–a review [PDF]

Acta Orthopaedica Scandinavica, 2004
Gastrointestinal stromal tumors (GISTs) may be defined as intraabdominal nonepithelial (mesenchymal) tumors that express the KIT protein or have an activating mutation in a class III receptor tyrosine kinase gene (KIT or PDGFRA). GISTs are diagnosed at a frequency of about 15 new cases annually per million, though small indolent GISTs are likely to ...
H, Joensuu, L G, Kindblom
openaire   +2 more sources

Radiation‐Induced Tumor‐Intrinsic LTβR N‐Glycosylation Suppresses Pyroptosis Through TRIM28‐Mediated PCBP2 SUMOylation to Promote Gastric Cancer Radioresistance

Advanced Science, EarlyView.
Radiotherapy triggers LTβR N‐glycosylation, enhancing its overall protein stability and nuclear retention. This accumulation drives TRIM28‐mediated PCBP2 SUMOylation, suppressing pyroptosis and conferring gastric cancer radioresistance. Therapeutically, a targeted nanoplatform (cRGD‐Lipo@EMD) effectively disrupts this regulatory axis, offering a highly
Weijie Zang, Yunlong Ji, Chunwang Zhou, Xiwen Li, Zhuang Lu, Guangze Zhang, Yu Chen, Wanjiang Xue, Yilin Hu   +8 more
wiley   +1 more source

Neuron‐Derived MIF Engages VCAM1 to Fuel a Self‐Amplifying CXCL8 Loop That Drives Perineural Invasion and Metastasis in Gastric Cancer

Advanced Science, EarlyView.
Neuron‐derived MIF binds VCAM1 on gastric cancer cells and activates ERK/STAT3 signaling, leading to CXCL8 transcription and secretion. Tumor‐derived CXCL8 subsequently stimulates neuronal CXCR2 to enhance MIF production, establishing a self‐amplifying MIF–VCAM1–CXCL8 positive‐feedback loop that promotes perineural invasion, tumor progression, and ...
Xunjun Li, Zhongya Zhai, Haiyi Yu, Renjie Qiu, Fengyu Li, Luxi Xiao, Boxi Huang, Huiying Liu, Jiayong He, Bowen Cai, Jiawen Chen, Jiang Yu, Guoxin Li, Tao Chen   +13 more
wiley   +1 more source

The role of radiomics in diagnosing gastrointestinal stromal tumors: a review

Digital Diagnostics
Gastrointestinal stromal tumors are the most common mesenchymal neoplasms of the gastrointestinal tract originating from the interstitial cells of Cajal, accounting for approximately 80% of all primary gastric tumors.
Elina A. Martirosyan, Grigory G. Karmazanovsky, Evgeny V. Kondratyev, Elena A. Sokolova, Valentin A. Nechaev, Evgeniya S. Kuzmina, Vsevolod N. Galkin, Andrey V. Glotov   +7 more
doaj   +1 more source

Cytomorphology of gastrointestinal stromal tumors and extra-gastrointestinal stromal tumors: A comprehensive morphologic study

Journal of Cytology, 2013
Background: The term gastrointestinal stromal tumors (GIST) is used to refer to those mesenchymal neoplasms of the gastrointestinal tract (GIT) which express CD117, a c-kit proto-oncogene protein. Aims: To study the cytological features of GIST and extra-
M Vij, V Agrawal, A Kumar, R Pandey
doaj   +1 more source