Results 11 to 20 of about 774,303 (341)

The correlation between the margin of resection and prognosis in esophagogastric junction adenocarcinoma

World Journal of Surgical Oncology, 2023
Adenocarcinoma of the gastroesophageal junction (AEG) has become increasingly common in Western and Asian populations. Surgical resection is the mainstay of treatment for AEG; however, determining the distance from the upper edge of the tumor to the ...
Tao Pang, Mingming Nie, Kai Yin
doaj   +1 more source

Adjuvant SOX chemotherapy versus concurrent chemoradiotherapy after D2 radical resection of locally advanced esophagogastric junction (EGJ) adenocarcinoma: study protocol for a randomized phase III trial (ARTEG)

Trials, 2021
Background Survival benefit of adjuvant radiotherapy for locally advanced gastric cancer following gastrectomy plus D2 lymphadenectomy has always been controversial.
Jinwen Shen, Xiu Zhu, Yian Du, Yuan Zhu, Pengfei Yu, Litao Yang, Zhiyuan Xu, Ling Huang, Yunli Zhang, Yanqiang Zhang, Luying Liu, Xiangdong Cheng   +11 more
doaj   +1 more source

Phase I/II clinical trial of nivolumab in combination with oligo-fractionated irradiation for unresectable advanced or recurrent gastric cancer

Communications Medicine, 2023
Background Although immune checkpoint inhibitors (ICI) targeting for PD-1 axis is a promising approach for advanced gastric cancer (GC) patients, the response rate is still limited.
Kosaku Mimura, Takashi Ogata, Yuya Yoshimoto, Daisaku Yoshida, Shotaro Nakajima, Hisashi Sato, Nozomu Machida, Takanobu Yamada, Yohei Watanabe, Tomoaki Tamaki, Hirohito Fujikawa, Yasuhiro Inokuchi, Suguru Hayase, Hiroyuki Hanayama, Zenichiro Saze, Hiroyuki Katoh, Fumiaki Takahashi, Takashi Oshima, Yoshiyuki Suzuki, Koji Kono   +19 more
doaj   +1 more source

Intestinal macromolecular transport supporting adaptive immunity [PDF]

, 2019
The gastrointestinal tract performs opposing functions of nutrient absorption, barrier maintenance, and the delivery of luminal substances for the appropriate induction of tolerogenic or protective adaptive immunity.
Kulkarni, Devesha H, Newberry, Rodney D
core   +2 more sources

Risk factors for early and late morbidity in patients with cardiovascular disease undergoing inguinal hernia repair with a tailored approach: a single-center cohort study

BMC Surgery, 2023
Background Inguinal hernia repair is a common procedure in surgery. Patients with cardiovascular disease have an increased operative risk for postoperative morbidity.
Kamran Hajili, Alberto Vega Hernandez, Jakob Otten, Dana Richards, Claudia Rudroff   +4 more
doaj   +1 more source

Self-reinoculation with fecal flora changes microbiota density and composition leading to an altered bile-acid profile in the mouse small intestine [PDF]

, 2019
Background: The upper gastrointestinal tract plays a prominent role in human physiology as the primary site for enzymatic digestion and nutrient absorption, immune sampling, and drug uptake.
Bogatyrev, Said R., Ismagilov, Rustem F., Rolando, Justin C.   +2 more
core   +1 more source

Protein degradation technology: a strategic paradigm shift in drug discovery

Journal of Hematology & Oncology, 2021
Targeting pathogenic proteins with small-molecule inhibitors (SMIs) has become a widely used strategy for treating malignant tumors. However, most intracellular proteins have been proven to be undruggable due to a lack of active sites, leading to a ...
Haobin Li, Jinyun Dong, Maohua Cai, Zhiyuan Xu, Xiang-Dong Cheng, Jiang-Jiang Qin   +5 more
doaj   +1 more source

Cannabis and the Gastrointestinal Tract

Journal of Pharmacy & Pharmaceutical Sciences, 2020
Cannabis has been used for its medicinal purposes since ancient times. Its consumption leads to the activation of Cannabis receptors CB1 and CB2 that, through specific mechanisms can lead to modulation and progression of inflammation or repair. The novel findings are linked to the medical use of Cannabis in gastrointestinal (GI) system.
Manuela G. Neuman, Lawrence Cohen
openaire   +5 more sources

Radiological findings spectrum of asymptomatic coronavirus (COVID-19) patients

The Egyptian Journal of Radiology and Nuclear Medicine, 2020
Background Radiological examinations of COVID-19 positive patients play a vital role in early diagnosis and assessment of disease course, as most COVID-19 infected patients were diagnosed with pneumonia and characteristic CT imaging patterns ...
Rasha Mostafa Mohamed Ali, Mai Bahgat Ibrahim Ghonimy   +1 more
doaj   +1 more source

Post-COVID-19 pneumonia lung fibrosis: a worrisome sequelae in surviving patients

The Egyptian Journal of Radiology and Nuclear Medicine, 2021
Background Progressive fibrotic lung disease is one of the possible consequences of COVID-19 pulmonary pneumonia, and it is one of the most worrying long-term complications. Pulmonary fibrosis is associated with non-reversible lung dysfunction.
Rasha Mostafa Mohamed Ali, Mai Bahgat Ibrahim Ghonimy   +1 more
doaj   +1 more source