Results 41 to 50 of about 1,251,513 (308)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

The impact of CLDN18.2 expression on effector cells mediating antibody-dependent cellular cytotoxicity in gastric cancer

Scientific Reports
Activating antibody-dependent cellular cytotoxicity (ADCC) by targeting claudin-18 isoform 2 (CLDN18.2) using zolbetuximab, a monoclonal antibody against CLDN18.2, has been considered a promising novel therapeutic strategy for gastric cancer (GC ...
Akira Matsuishi, Shotaro Nakajima, Motonobu Saito, Katsuharu Saito, Satoshi Fukai, Hideaki Tsumuraya, Ryo Kanoda, Tomohiro Kikuchi, Azuma Nirei, Akinao Kaneta, Hirokazu Okayama, Kosaku Mimura, Hiroyuki Hanayama, Wataru Sakamoto, Tomoyuki Momma, Zenichiro Saze, Koji Kono   +16 more
doaj   +1 more source

Histology of the gastrointestinal tract of the northern brown bandicoot, Isoodon macrourus (Marsupialia: Peramelidae)

, 2011
Published information on the histology of the gastrointestinal tract of peramelids is limited, with previous research only examining portions of the tract. We examined the histological structure of the gastrointestinal tract of eight adult I.
Klieve, Athol V., Peter J. Murray, O'Hara, Patricia J., Murray, Peter J., Patricia J. O'Hara, Athol V. Klieve   +5 more
core   +1 more source

Gasotransmitters in the gastrointestinal tract [PDF]

Surgery, 2008
The 1990s initiated a new paradigm for cell-to-cell signal transduction via “neurotransmitters” with the discovery that a gas, nitric oxide (NO), could be released specifically from nerves and act to transmit the “neural signal” secondary to nerve stimulation.
Michael S, Kasparek, David R, Linden, Martin E, Kreis, Michael G, Sarr   +3 more
openaire   +2 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Downregulation of cGAS/STING expression in tumor cells by cancer-associated fibroblasts in colorectal cancer

Scientific Reports
The tumor cell-intrinsic cyclic GMP–AMP synthase (cGAS)–stimulator of interferon genes (STING) pathway is critical for activating anti-tumor immunity and enhancing immune checkpoint blockade therapy in colorectal cancer (CRC).
Ryo Kanoda, Shotaro Nakajima, Hirokazu Okayama, Akinao Kaneta, Shun Chida, Takuro Matsumoto, Katsuharu Saito, Tomohiro Kikuchi, Yuya Maruyama, Hiroya Suzuki, Kosaku Mimura, Motonobu Saito, Hiroyuki Hanayama, Wataru Sakamoto, Tomoyuki Momma, Zenichiro Saze, Koji Kono   +16 more
doaj   +1 more source

Diagnosis and treatment of gastric hamartomatous inverted polyp (GHIP) using a modified combination of laparoscopic and endoscopic approaches to neoplasia with a non-exposure technique (modified CLEAN-NET): a case report

Surgical Case Reports, 2020
Background Gastric hamartomatous inverted polyp (GHIP) is a pathological condition where enlarged gastric glands with cystic dilatation grow in the submucosa. It is difficult to excise the tissue due to its location.
Suguru Hayase, Mei Sakuma, Shun Chida, Masaru Saito, Hirofumi Ami, Yoshihisa Koyama, Shinji Ohki, Koji Kono   +7 more
doaj   +1 more source

An investigation of a Mollicute-like organism inhabiting the human gastrointestinal tract [PDF]

, 2009
The microflora inhabiting the human gastrointestinal tract can be considered an essential 'metabolic organ', in a symbiotic relationship with its host. Due to the low cultivability and inappropriate sampling methodology the microflora is poorly explored ...
Care, Andrew Shane
core  

Upper gastrointestinal tract [2]

, 2023
Upper gastrointestinal tract ...
Brendan Crotty (13060500), J Hayllar (13611562), A J Mclean (13611565), R A Smallwood (13611568)   +3 more
core  

Metatranscriptome analysis of the human fecal microbiota reveals subject-specific expression profiles, with genes encoding proteins involved in carbohydrate metabolism being dominantly expressed [PDF]

, 2010
The human gastrointestinal (GI) tract provides home to a complex microbial community, collectively termed microbiota. Although major efforts have been made to describe the diversity and stability of the microbiota, functional studies have been largely ...
Vos, W.M., de, Kleerebezem, M., Smidt, H., Zoetendal, E.G., Hauke Smidt, Booijink, C.C.G.M., Erwin G. Zoetendal, Carien C. G. M. Booijink, Boekhorst, J., te, Michiel Kleerebezem, Jos Boekhorst, Willem M. de Vos   +11 more
core   +1 more source