Results 51 to 60 of about 1,198,615 (311)

Diagnosis and treatment of gastric hamartomatous inverted polyp (GHIP) using a modified combination of laparoscopic and endoscopic approaches to neoplasia with a non-exposure technique (modified CLEAN-NET): a case report

Surgical Case Reports, 2020
Background Gastric hamartomatous inverted polyp (GHIP) is a pathological condition where enlarged gastric glands with cystic dilatation grow in the submucosa. It is difficult to excise the tissue due to its location.
Suguru Hayase, Mei Sakuma, Shun Chida, Masaru Saito, Hirofumi Ami, Yoshihisa Koyama, Shinji Ohki, Koji Kono   +7 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Downregulation of cGAS/STING expression in tumor cells by cancer-associated fibroblasts in colorectal cancer

Scientific Reports
The tumor cell-intrinsic cyclic GMP–AMP synthase (cGAS)–stimulator of interferon genes (STING) pathway is critical for activating anti-tumor immunity and enhancing immune checkpoint blockade therapy in colorectal cancer (CRC).
Ryo Kanoda, Shotaro Nakajima, Hirokazu Okayama, Akinao Kaneta, Shun Chida, Takuro Matsumoto, Katsuharu Saito, Tomohiro Kikuchi, Yuya Maruyama, Hiroya Suzuki, Kosaku Mimura, Motonobu Saito, Hiroyuki Hanayama, Wataru Sakamoto, Tomoyuki Momma, Zenichiro Saze, Koji Kono   +16 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

CMS4 epithelial-intrinsic glycosyltransferase GALNT5 promotes tumor aggressiveness and correlates with poor survival in colorectal cancer

Scientific Reports
The “mesenchymal” consensus molecular subtype 4 (CMS4) of colorectal cancer (CRC) has the poorest prognosis and shows stromal activation and bulk epithelial-mesenchymal transition (EMT) signatures that largely reflect cancer-associated fibroblast-derived
Sohei Hayashishita, Hirokazu Okayama, Shotaro Nakajima, Katsuharu Saito, Chiaki Takiguchi, Dai Mitsui, Hajime Matsuida, Masanori Katagata, Takahiro Sato, Takuro Matsumoto, Daisuke Ujiie, Shun Chida, Zenichiro Saze, Motonobu Saito, Kosaku Mimura, Tomoyuki Momma, Koji Kono   +16 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Lower Gastrointestinal Tract Tuberculosis: An Important but Neglected Disease

, 2011
Purpose Difficulties in early and accurate diagnosis of intestinal tuberculosis lead to frequent misdiagnosis even in endemic areas. This study aimed to investigate clinical and laboratory characteristics of patients with lower gastrointestinal tract ...
LIN, PEI-YING;WANG, JANN-YUAN;HSUEH, PO-REN;LEE, LI-NA;HSIAO, CHENG-HSIANG;YU, CHONG-JEN;YANG, PAN-CHYR, 林佩瑩;王振源;薛博仁;李麗娜;蕭正祥;余忠仁;楊泮池   +1 more
core   +1 more source

Clinicopathological characteristics and stage-adjusted outcomes of sporadic pMMR/MSS early-onset colorectal cancer

BMC Gastroenterology
Background The global incidence of early-onset colorectal cancer (EOCRC) is increasing. The prognostic impact of EOCRC remains controversial, as it is largely confounded by hereditary syndromes and mismatch repair deficient (dMMR)/microsatellite ...
Tomoyuki Momma, Hirokazu Okayama, Makoto Hasegawa, Takahiro Kawamata, Chiaki Takiguchi, Satoshi Fukai, Takahiro Sato, Misato Ito, Daisuke Ujiie, Shun Chida, Motonobu Saito, Koji Kono   +11 more
doaj   +1 more source

Residual Tumor Resection After Anti-PD-1 Therapy: A Promising Treatment Strategy for Overcoming Immune Evasive Phenotype Induced by Anti-PD-1 Therapy in Gastric Cancer

Cells
Background: Anti-programmed death 1 receptor (PD-1) therapy is a promising treatment strategy for patients with unresectable advanced or recurrent gastric/gastroesophageal junction (G/GEJ) cancer.
Hajime Matsuida, Kosaku Mimura, Shotaro Nakajima, Katsuharu Saito, Sohei Hayashishita, Chiaki Takiguchi, Azuma Nirei, Tomohiro Kikuchi, Hiroyuki Hanayama, Hirokazu Okayama, Motonobu Saito, Tomoyuki Momma, Zenichiro Saze, Koji Kono   +13 more
doaj   +1 more source