Results 41 to 50 of about 2,027,318 (403)

Epithelial‐mesenchymal transition‐converted tumor cells can induce T‐cell apoptosis through upregulation of programmed death ligand 1 expression in esophageal squamous cell carcinoma

Cancer Medicine, 2018
Esophageal squamous cell carcinoma (ESCC) is an aggressive tumor, and it is urgently needed to develop novel therapeutic strategies including immunotherapy.
Aung Kyi Thar Min, Hirokazu Okayama, Motonobu Saito, Mai Ashizawa, Keita Aoto, Takahiro Nakajima, Katsuharu Saito, Suguru Hayase, Wataru Sakamoto, Takeshi Tada, Hiroyuki Hanayama, Zenichirou Saze, Tomoyuki Momma, Shinji Ohki, Yusuke Sato, Satoru Motoyama, Kosaku Mimura, Koji Kono   +17 more
doaj   +1 more source

Anti‐PD‐1 monoclonal antibody‐resistant esophageal squamous cell carcinoma showing the abscopal effect: A case report with T‐cell receptor/B‐cell receptor repertoire analysis

Cancer Reports, 2023
Background Several clinical trials of nivolumab have reported good results, including those in patients with advanced esophageal squamous cell carcinoma. However, the response rate of this drug remains poor.
Yuka Takehara, Kosaku Mimura, Yoshiyuki Suzuki, Yohei Watanabe, Yuya Yoshimoto, Zenichiro Saze, Hisashi Sato, Tomoaki Tamaki, Koji Kono   +8 more
doaj   +1 more source

Gastrointestinal Tract Disorders in Older Age

Canadian Journal of Gastroenterology and Hepatology, 2019
Considering an increase in the life expectancy leading to a rise in the elderly population, it is important to recognize the changes that occur along the process of aging.
Igor Dumic, T. Nordin, M. Jecmenica, Milica Stojkovic Lalosevic, T. Milosavljevic, Tamara Milovanović   +5 more
semanticscholar   +1 more source

The zebrafish as a model for gastrointestinal tract–microbe interactions

Cellular Microbiology, 2019
The zebrafish (Danio rerio) has become a widely used vertebrate model for bacterial, fungal, viral, and protozoan infections. Due to its genetic tractability, large clutch sizes, ease of manipulation, and optical transparency during early life stages, it
Erika M Flores, A. T. Nguyen, Max A. Odem, G. T. Eisenhoffer, A. Krachler   +4 more
semanticscholar   +1 more source

MLH1 germline mutation associated with Lynch syndrome in a family followed for more than 45 years

BMC Medical Genetics, 2019
Background Lynch syndrome, is an autosomal dominantly inherited disease that predisposes individuals to a high risk of colorectal cancers, and some mismatch-repair genes have been identified as causative genes.
Tomoyuki Momma, Kenji Gonda, Yoshinori Akama, Eisei Endo, Daisuke Ujiie, Shotaro Fujita, Yuko Maejima, Shoichiro Horita, Kenju Shimomura, Shigehira Saji, Koji Kono, Rei Yashima, Fumiaki Watanabe, Kokichi Sugano, Tadashi Nomizu   +14 more
doaj   +1 more source

Review of mycotoxin reduction in food and feed: from prevention in the field to detoxification by adsorption or transformation [PDF]

, 2011
Mycotoxins are secondary metabolites present worldwide in agricultural commodities and produced by filamentous fungi that cause a toxic response (mycotoxicosis) when ingested by animals.
Guyonvarc’h, Alain, Jard, Gwénaëlle, Lebrihi, Ahmed, Liboz, Thierry, Mathieu, Florence   +4 more
core   +2 more sources

Akkermansia muciniphila in the Human Gastrointestinal Tract: When, Where, and How?

Microorganisms, 2018
Akkermansia muciniphila is a mucin-degrading bacterium of the phylum Verrucomicrobia. Its abundance in the human intestinal tract is inversely correlated to several disease states. A.
Sharon Y. Geerlings, Ioannis Kostopoulos, W. D. de Vos, C. Belzer   +3 more
semanticscholar   +1 more source

Review article: pathogenesis and clinical manifestations of gastrointestinal involvement in systemic sclerosis. [PDF]

, 2017
BACKGROUND: Gastrointestinal tract (GIT) involvement is a common cause of debilitating symptoms in patients with systemic sclerosis (SSc). There are no disease modifying therapies for this condition and the treatment remains symptomatic, largely owing to
Abraham, Assandri, Assassi, Auluck, Bacher, Baron, Baron, Bodukam, Cavazzana, Chizzolini, Chizzolini, Ciechomska, Clark, Cohen, Colina, Crowell, Denton, Denton, Derk, Derynck, Emmanuel, Frech, Fynne, Gabrielli, Goldblatt, Gregersen, Gu, Hartleb, Heyt, Hinz, Hu, Hudson, Hung, Ingraham, Jimenez, Johnson, Jung, Kaburaki, Kaneko, Khanna, Khanna, Koh, Krause, Kumar, Luciano, Malandrini, Manetti, Manetti, Manetti, Marie, Marie, Marie, Marie, Marie, Matucci-Cerinic, Maurer, Miao, Milette, Murray-Lyon, Nagaraja, O'Reilly, O'Reilly, Omair, Parker, Parodi, Pattanaik, Peng, Piasecki, Poelman, Radic, Raja, Raja, Raja, Rajapakse, Reynolds, Richard, Richardson, Rigamonti, Riviere, Roulis, Russell, Sakkas, Savarino, Savarino, Shawis, Singh, Singh, Sjogren, Skare, Solis-Herruzo, Spiegel, Steen, Stern, Stumpf, Thonhofer, Thoua, Trezza, Trojanowska, Valenzuela, Varga, Veale, Vischio, Watson, Wipff, Wynn, Zheng   +105 more
core   +2 more sources

Analysis of Transcriptionally Active Bacteria Throughout the Gastrointestinal Tract of Healthy Individuals.

Gastroenterology, 2019
BACKGROUND & AIMS The microbiome varies along the human gastrointestinal (GI) tract with exposure to luminal and mucosal factors. We analyzed active bacterial communities at 8 locations along the GI tract using high-throughput sequencing techniques ...
R. Vasapolli, K. Schütte, C. Schulz, M. Vital, Dirk Schomburg, D. Pieper, R. Vílchez-Vargas, P. Malfertheiner   +7 more
semanticscholar   +1 more source

Mucosubstances in the porcine gastrointestinal tract: Fixation, staining and quantification [PDF]

, 2019
Mucins are of great interest in intestinal research and histochemical methods are often employed to identify them. Since it is in the nature of mucins that they are “hard to hold onto” once they come into contact with water, a frequently used medium in ...
Drewes, Barbara, Hünigen, Hana, Plendl, Johanna, Rieger, Juliane   +3 more
core   +1 more source