Results 111 to 120 of about 6,168 (196)

PARP1 Modulates GATA3-Mediated Gene Regulation In Breast Cancer [PDF]

In eukaryotic cells, chromatin acts as a physical barrier for many transcription factors, preventing them from efficiently binding to their recognition sequences within the nucleosome.
Cooper, Mikhala
core   +1 more source

PU.1 Suppresses Th2 Cytokine Expression via Silencing of GATA3 Transcription in Dendritic Cells.

PLoS ONE, 2015
The transcription factor PU.1 is predominantly expressed in dendritic cells (DCs) and is essential for DC differentiation. Although there are several reports that PU.1 positively regulates the expression of DC-specific genes, whether PU.1 also has a ...
Takuya Yashiro, Masato Kubo, Hideoki Ogawa, Ko Okumura, Chiharu Nishiyama   +4 more
doaj   +1 more source

Epigenetic control of cellular plasticity in breast cancer progression

The FEBS Journal, EarlyView.
Cancer cells undergo cell state transitions, termed plasticity, driving cancer progression and dictating therapeutic response. We define breast cancer plasticity into four interconnected processes: (1) breast cancer stem cell fates, (2) epithelial‐to‐mesenchymal transition, (3) maintenance of luminal identity, and (4) acquisition of therapeutic ...
Ellie J. Massey, Elizabeth Podleszanski, William J. Muller   +2 more
wiley   +1 more source

NFE2L2‐mutated urothelial carcinomas frequently show concomitant myxoid and squamous features and have high PD‐L1 expression

Histopathology, EarlyView.
Aims NFE2L2 encodes the transcription factor, NRF2, which is a regulator of cellular oxidative stress responses and metabolic homeostasis. NFE2L2 alterations are implicated in multiple cancers, with significant study in thoracic oncology, with an adverse prognosis, aggressive behaviour, metabolic reprogramming and diminished responses to chemotherapy ...
Dane Wuori, Alexander Guzzetta, Melissa Y. Tjota, Peng Wang, Tatjana Antic, Jung Woo Kwon   +5 more
wiley   +1 more source

Gata3-deficient mice develop parathyroid abnormalities due to dysregulation of the parathyroid-specific transcription factor Gcm2

, 2010
Heterozygous mutations of GATA3, which encodes a dual zinc-finger transcription factor, cause hypoparathyroidism with sensorineural deafness and renal dysplasia. Here, we have investigated the role of GATA3 in parathyroid function by challenging Gata3+/–
Stacey, Joanna M., Kurek, Dorota, Ali, A, Grigorieva, Irina V., Nancy Manley, Fairclough, R.J. (Rebecca), Hough, D.M. (David), Rebecca J. Fairclough, Grigorieva, I.V. (Irina), Fraser, WD, Kurek, D. (Dorota), Mihai, R. (Radu), Elena F. Grigorieva, Fairclough, RJ, Irina V. Grigorieva, Manley, N, Gaynor, K.U. (Katherine), Grosveld, Frank, William D. Fraser, Nesbit, M. Andrew, Mihai, Radu, Grigorieva, E.F. (Elena), Mihai, R, Tertius Hough, Rajesh V. Thakker, Ali, Asif, Katherine U. Gaynor, Joanna M. Stacey, Nesbit, M.A. (M. Andrew), Ali, A. (Asif), Wei, QZ, Brian G. Condie, Wei, Qiaozhi, Hough, Tertius, Mirczuk, S, Stechman, MJ, Stechman, Michael J., Condie, B.G. (Brian), Manley, G. (Geoffrey), Grosveld, F.G. (Frank), Asif Ali, Thakker, R.V. (Rajesh), Frank Grosveld, Condie, Brian G., Thakker, RV, Mirczuk, S. (Samantha), Stacey, JM, Gaynor, Katherine U., Wei, Q. (Qiaozhi), Grigorieva, Elena F., Nesbit, MA, M. Andrew Nesbit, Manley, Nancy, Hough, T, Stacey, J.M. (Joanna), Samantha Mirczuk, Michael J. Stechman, Thakker, Rajesh V., Qiaozhi Wei, Mirczuk, Samantha, Grigorieva, EF, Stechman, M.J. (Michael), Grigorieva, IV, Condie, BG, Dorota Kurek, Fairclough, Rebecca J., Fraser, William D., Radu Mihai, Fraser, W.D. (William), Gaynor, KU   +69 more
core   +1 more source

Merkel cell carcinoma: an updated guide for pathologists

Histopathology, EarlyView.
Merkel cell carcinoma (MCC) is an aggressive cutaneous neuroendocrine carcinoma for which the differential diagnosis can include other small cell malignancies (especially metastatic small cell carcinoma) or cutaneous carcinoma. Morphologic and immunophenotypic aberrancies in MCC can increase diagnostic challenge.
Paul W. Harms
wiley   +1 more source

GATA3 regulates Th1/Th2 balance in allergic rhinitis by interacting with RUNX1

Future Science OA
Objective To investigate the action mechanism of GATA3 and Runt-related transcription factor 1(RUNX1) in modulating regulatory the Th1/Th2 cell differentiation and treat allergic rhinitis (AR).Methods Established AR model mice by ovalbumin (OVA) and ...
Yuxiao Li, Tianrong Wang, Ming He, Yu Wang, Jiayan He   +4 more
doaj   +1 more source

Cutaneous lymphomas – an update

Histopathology, EarlyView.
Primary cutaneous lymphomas and lymphoproliferative disorders are defined by integrated clinical, histopathological, immunophenotypic and genetic features as diagnostic criteria also in the 5th edition of the WHO classification of haematolymphoid tumors.
Werner Kempf, Christina Mitteldorf
wiley   +1 more source

Comparison of overall survival curves between GATA3-positive (continuous line) and -negative (dotted line) cases.

, 2016
(A) Among all STS cases, OS for GATA3-positive cases was significantly worse than that for GATA3-negative cases (P = 0.0006). (B) Among FNCLCC histological grade 1 and (C) FNCLCC histological grade 2/3 cases, GATA3-positive cases experienced ...
Toshihiro Hashiguchi (2818372), Toshiaki Haraguchi (2818357), Hiroaki Miyoshi (2818363), Takahiro Okawa (2818366), Koutaro Matsuda (2818369), Koji Hiraoka (2818354), Yukinao Ishibashi (2818351), Shintaro Yokoyama (2818360), Tetsuya Hamada (2458012), Koichi Ohshima (230585), Naoto Shiba (785968)   +10 more
core   +1 more source

The Role of Innate Lymphoid Cells in Autoimmune, Allergic and Infectious Diseases: A Systematic Review

Immunology, EarlyView.
This systematic review establishes disease‐specific dysregulations of human innate lymphoid cells (ILCs), demonstrating that an ILC1/ILC3 imbalance compromises mucosal barriers in inflammatory bowel disease, while activated ILC2s drive allergic airway inflammation.
Luan F. Lückmann, Henrique R. Dal‐Pizzol, Louise M. Lückmann, Davi E. Salini, Bruna C. Hasckel, Mikaeli Minati, Bruno Kluwe‐Schiavon, Tatiana Barichello   +7 more
wiley   +1 more source