Results 101 to 110 of about 6,168 (196)

Meta-analysis of human cancer microarrays reveals GATA3 is integral to the estrogen receptor alpha pathway

Molecular Cancer, 2008
Background The transcription factor GATA3 has recently been shown to be necessary for mammary gland morphogenesis and luminal cell differentiation. There is also an increasing body of data linking GATA3 to the estrogen receptor α (ERα) pathway.
Giguère Vincent, Wilson Brian J
doaj   +1 more source

Derivation of Mouse Dome‐Shaped Trophoblast Stem Cells With Low Heterogeneity From Blastocysts

Cell Proliferation, EarlyView.
Here, Liu et al. report the generation of mouse dome‐shaped trophoblast stem cells (dTSCs) with low heterogeneity and autonomous differentiation potential. dTSCs robustly generate all trophoblast lineages in vitro and contribute to the placenta in vivo, providing a refined model for studying trophoblast development and related disorders.
Minli Liu, Shaofang Ren, Xinyu Xia, Guanlin Lu, Haojie Yang, Yi Zheng, Jiexiang Zhao, Xiao‐Yang Zhao, Mei Wang   +8 more
wiley   +1 more source

GATA3 interacts with and stabilizes HIF-1α to enhance cancer cell invasiveness

, 2017
GATA binding protein 3 (GATA3) is indispensable in development of human organs. However, the role of GATA3 in cancers remains elusive. Hypoxia inducible factor (HIF)-1 plays an important role in pathogenesis of human cancers.
P-J Lou, J-J Lin, H-F Juan, M-C Huang, C-L Hsu, M-C Lin   +5 more
core   +1 more source

GATA2 and GATA3 role in trophoblast development and hematopoiesis development

, 2022
I study GATA2 and GATA3 role in trophoblast development and hematopoiesis development. I combine Crispr Cas9 for double knockout both GATA2 and GATA3. GATA2&3 DKO cell was characterized with IF stianing, WB.
Jilong Guo (9067589)
core   +1 more source

GATA3 abnormalities in six patients with HDR syndrome

Endocrine Journal, 2011
GATA3 mutations cause HDR (hypoparathyroidism, sensorineural deafness, and renal dysplasia) syndrome and, consistent with the presence of the second DiGeorge syndrome locus (DGS2) proximal to GATA3, distal 10p deletions often leads to HDR and DiGeorge syndromes. Here, we report on six Japanese patients with GATA3 abnormalities.
Fukami, Maki, Muroya, Koji, Miyake, Tetsuo, Iso, Manami, Kato, Fumiko, Yokoi, Hisashi, Suzuki, Yoshimi, Tsubouchi, Koji, Nakagomi, Yoshiko, Kikuchi, Nobuyuki, Horikawa, Reiko, Ogata, Tsutomu   +11 more
openaire   +3 more sources

Olfactory Tuft Cells Are Critical to Basal Inflammation, Innate Immune Response to Viral Infection, and Modulation of Quiescent Stem Cell Activation, Proliferation and Differentiation

Cell Proliferation, EarlyView.
Olfactory tuft cells communicate with other mucosal cells in maintaining olfactory epithelial immunity and sensory function. Disruption of tuft cell signalling pathways causes a skewed immune response, leading to heightened inflammation and increased activation of the quiescent stem cells, which are further exacerbated by viral infection.
Sai‐Sai Zhang, Haiyan Wang, Yi‐Sen Yang, Yi‐Hong Li, Defu Yu, Yushi Yao, Ruhong Zhou, Liquan Huang   +7 more
wiley   +1 more source

Functionally distinct Gata3/Chd4 complexes coordinately establish T helper 2 (Th2) cell identity

, 2013
GATA binding protein 3 (Gata3) is a GATA family transcription factor that controls differentiation of naïve CD4 T cells into T helper 2 (Th2) cells. However, it is unknown how Gata3 simultaneously activates Th2-specific genes while repressing those of ...
Tanaka, T., Tumes, D.J., Ohkubo, S., Onodera, A., Nakayama, T., Endo, Y., Kanai, A., Endoh, K., Kato, M., Suzuki, Y., Iwamura, C., Hosokawa, H., Sugano, S.   +12 more
core   +1 more source

Cytology‐First Diagnostic Workflow for Melanoma of Unknown Primary With Molecular Profiling

Cytopathology, EarlyView.
Cytology‑first diagnostic workflow for melanoma of unknown primary. Fine‑needle aspiration of an enlarged lymph node enables rapid cytologic evaluation and immunocytochemical confirmation of melanocytic lineage (SOX10). This early cytologic diagnosis facilitates timely surgical excision and comprehensive genomic profiling, supporting integrated ...
Hong Yu, Mokhtar Abdelhammed, Xu Cao, Nisha S. Ramani   +3 more
wiley   +1 more source

Genome-Wide Analysis Reveals Unique Regulation of Transcription of Th2-Specific Genes by GATA3

, 2011
Differentiation of naive CD4 T cells into Th2 cells is accompanied by chromatin remodeling and increased expression of a set of Th2-specific genes, including those encoding Th2 cytokines.
Tomoaki Tanaka, Shu Horiuchi, Atsushi Onodera, Toshinori Nakayama, Hiroyuki Hosokawa, Yukiko Watanabe, Sumio Sugano, Yutaka Suzuki   +7 more
core   +1 more source

Association of GATA3 expression in triple-positive breast cancer with overall survival and immune cell infiltration

Scientific Reports
Breast cancer remains a leading cause of cancer-related mortality among women, with triple-positive breast cancer (TPBC) being a particularly aggressive subtype. GATA binding protein 3 (GATA3) plays a crucial role in the luminal differentiation of breast
Xiuwen Chen, Weilin Zhao, Yugang Huang, Senyuan Luo, Xianbin Tang, Qiong Yi   +5 more
doaj   +1 more source