Results 81 to 90 of about 6,168 (196)

GATA3 upregulates BMP5 in MB-231 cells.

, 2013
(A) Q-RT-PCR showing expression of BMP2, BMP4 and BMP5 in 231-Empty and 231-GATA3 cells. GATA3 significantly upregulates BMP5 expression in MB-231 cells.
Lara H. El Touny (400239), Jeffrey E. Green (155226), Hosein Kouros-Mehr (18686), Olga Aprelikova (73933), Isabel M. Chu (400237), Wei-Chu Lai (400238)   +5 more
core   +1 more source

Invasive micropapillary urothelial carcinoma of the renal pelvis presenting as nonfunctional kidney: A unique presentation and review of the literature

Indian Journal of Pathology and Microbiology
Micropapillary urothelial carcinoma of the renal pelvis is a rare and aggressive variant and poses a diagnostic challenge, especially related to the site and histomorphology of the tumor. A 60-year-old female presented with right pelvic-ureteric junction
Mohammed Shahin, Sagar R. Tripathy, Prasant Nayak, Prasanna Ram, Pavithra Ayyanar   +4 more
doaj   +1 more source

GATA3 expression is decreased in psoriasis and during epidermal regeneration; induction by narrow-band UVB and IL-4.

PLoS ONE, 2011
Psoriasis is characterized by hyperproliferation of keratinocytes and by infiltration of activated Th1 and Th17 cells in the (epi)dermis. By expression microarray, we previously found the GATA3 transcription factor significantly downregulated in lesional
Emoke Rácz, Dorota Kurek, Marius Kant, Ewout M Baerveldt, Edwin Florencia, Sabine Mourits, Dick de Ridder, Jon D Laman, Leslie van der Fits, Errol P Prens   +9 more
doaj   +1 more source

Lupus Panniculitis Immunoprofiling Reveals a Cytotoxic, Type 1‐Skewed T‐Cell Response With Signs of Metabolic Alteration

Allergy, EarlyView.
Imaging mass cytometry shows lupus panniculitis lesions are dominated by cytotoxic and skin‐homing T cells with abundant macrophages and B‐cell aggregates. Spatial neighborhood analysis reveals organized leukocyte architecture, including B‐cell proximity to naïve T cells and M1 macrophages to cytotoxic T cells.
Milad Ameri, Reihane Ziadlou, Stephan Traidl, Milena Sokolowska, Emmanuel Contassot, Nick Li, Maija Kiuru, Isabel Kolm, Werner Kempf, Emanual Maverakis, Cezmi Akdis, Marie‐Charlotte Brüggen   +11 more
wiley   +1 more source

Serotonin Degradation and Lipid Metabolism Regulate Human Tc2 Cell Effector Functions

Allergy, EarlyView.
Human Tc2 cells exhibit a metabolically active phenotype characterized by enhanced glycolysis, mitochondrial respiration, and fatty acid uptake dependent on PPARγ. Alarmins strongly amplify IL‐5 and IL‐13 production in Tc2 cells, supporting a shared immunometabolic program across type 2 lymphocytes.
Sabrina de Souza Ferreira, Lisa Holla, Sophia Björkander, Marie Kaarup Bek, Lorenz Wirth, Patrick A. Shearer, Jesper Säfholm, Erik Sachs, Mamdoh Al‐Ameri, Kasra Vali, Sandra Ekström, Erik Melén, Jenny Mjösberg, Christopher Andrew Tibbitt   +13 more
wiley   +1 more source

Long Noncoding RNA GATA3-AS1 Promotes Cell Proliferation and Metastasis in Hepatocellular Carcinoma by Suppression of PTEN, CDKN1A, and TP53

Canadian Journal of Gastroenterology and Hepatology, 2019
Background. Long noncoding RNAs (lncRNAs) have been known to play important roles in the progression of various types of human cancer. LncRNA GATA3 antisense RNA 1, GATA3-AS1, has been reported to be associated with T-cell development and differentiation.
Xuee Luo, Ning Zhou, Le Wang, Qinghua Zeng, Hongying Tang   +4 more
doaj   +1 more source

Selective Absence of Co‐Inhibitory Receptor‐Expressing CD4+ T Cells in Lungs of Obese House Dust Mite‐Allergic C57BL/6 Mice

Allergy, EarlyView.
Obesity altered the inflammatory phenotype of HDM‐induced allergic airway inflammation in C57BL/6 mice, indicated by changed BAL cell composition. Single‐cell CITE‐Seq identified the lack of a CD4+ T‐cell subcluster characterized by co‐inhibitory receptor expression in obese HDM‐exposed C57BL/6 mice.
Sarah Miethe, Daniel P. Potaczek, Kim Pauck, Andrea Berlin, Bilal Alashkar Alhamwe, Stefanie Hagner, Andrea Nist, Elke Pogge von Strandmann, Thorsten Stiewe, Paul Klemm, Hartmann Raifer, Clemens Thölken, Holger Garn   +12 more
wiley   +1 more source

GATA3 and TGF-β in normal placenta and pre-eclampsia

: GATA3 plays critical roles in the development and function of various tissues and organs throughout the body. Likewise, TGF-β signaling is critical for placental development and can interact with GATA3.
Lucariello, Angela, Baldi, Alfonso, De Blasiis, Paolo, Perna, Angelica, Komici, Klara, Scala, Beatrice, De Luca, Antonio, Guerra, Germano, Sgambati, Eleonora, Hay, Eleonora   +9 more
core   +2 more sources

Single‐Cell Profiling Links T‐Cell Accumulation and TH2/TH17 Dynamics to Eosinophilic Esophagitis (EoE) Activity in Children

Allergy, EarlyView.
Active EoE is associated with more and deeper epithelial eosinophil, mast cell, and T cell infiltration; inactive EoE resembles controls. During remission, PPI treatment leaves more tissue resident CD3+ T‐cells than TS. In active EoE, TH2 cells, IL‐10hi Tregs, and CD8+ cytotoxic T cells are enriched, while TH17 cells are relatively depleted.
Hannes Hoelz, Matthias Tobias Warkotsch, Simon Buehler, Tim Faro, Sabrina Wagner, Valeriia Andrieieva, Alisia Beckmann, Anja Jurk, Marie‐Luise Frank, Guido Piontek, Kolja Siebert, Sebastian Jarosch, Sibylle Koletzko, Helga Paula Török, Christoph Walz, Martina Rudelius, Katja Steiger, Dirk Busch, Tobias Schwerd   +18 more
wiley   +1 more source

The Origins of Allergy: An Outside‐In, Bioenergetic Hypothesis

Allergy, EarlyView.
ABSTRACT Allergic disease has risen too rapidly for inherited susceptibility to explain it, and the risk variants so far reported lie in the epithelial barrier and in type‐2 immunity. We propose a five‐layer model in which epithelial barrier and bioenergetic dysfunction may precede and promote type‐2 immune deviation rather than arise solely as its ...
Peter K. Smith, Nicholas P. West, Stanley Du Preez, Hugh A. Sampson, Peter W. Hellings, David Price, Liam O'Mahony, Carina Venter, Cezmi A. Akdis, Gil Yosipovitch   +9 more
wiley   +1 more source