Results 61 to 70 of about 6,168 (196)

Loss of function of GATA3 regulates FRA1 and c-FOS to activate EMT and promote mammary tumorigenesis and metastasis

Cell Death and Disease, 2023
Basal-like breast cancers (BLBCs) are among the most aggressive cancers, partly due to their enrichment of cancer stem cells (CSCs). Breast CSCs can be generated from luminal-type cancer cells via epithelial-mesenchymal transition (EMT).
Xiong Liu, Feng Bai, Yuchan Wang, Chuying Wang, Ho Lam Chan, Chenglong Zheng, Jian Fang, Wei-Guo Zhu, Xin-Hai Pei   +8 more
doaj   +1 more source

Assessing the Mucosal Inflammatory Endotype of Obesity in Chronic Rhinosinusitis

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis (CRS) is a heterogeneous inflammatory syndrome of the paranasal sinuses that is defined phenotypically as either with nasal polyps (CRSwNP) or without nasal polyps (CRSsNP). More recently, inflammatory markers have been used to cluster patients into putative endotypes that are presumed to have a common ...
Jeffanie W. Gayoso, Li‐Ching Huang, Quanhu Sheng, Daniel Lofgren, Ping Li, Katherine Cahill, Mason Krysinski, Rakesh K. Chandra, Justin H. Turner, Naweed Chowdhury   +9 more
wiley   +1 more source

Spatiotemporal expression of Gata3 in auditory neurons.

, 2017
Cochlear cross sections (WT) from E13.5 to P30 immunostained against Gata3 and TuJ1. Gata3 (green) and TuJ1 (white) (A−F) and single channel of Gata3 (white) (A’−F’).
Teppei Noda (848954), Koji Nishimura (2077804), Alain Dabdoub (848958)   +2 more
core   +1 more source

Transcription Factor Assay of Peripheral Blood T cells in Different Groups of Rheumatoid Arthritis Patients

Research in Molecular Medicine, 2020
Background: Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation of the joints and other tissues and organs of the body.
Saeid Taghiloo, Abolghasem Ajami, Mohsen Tehrani, Arezou Abbasi, Reza Alizadeh-Navaei, Mohsen Akhiani, Alireza Salami   +6 more
doaj  

Homocitrullinated Peptides Drive Pro‐Inflammatory T Cell Responses in a Humanized Mouse Model of Rheumatoid Arthritis

Arthritis &Rheumatology, EarlyView.
Objective Anti‐homocitrullinated protein/peptide antibodies are specific to rheumatoid arthritis (RA) and predictive of worse prognosis, suggesting a pathogenic role for autoreactivity to homocitrullinated peptides (HomoCitP). However, T cell responses to HomoCitP remain largely unexplored.
Sofya Ulanova, Jaspreet Kaur, Gabrielle Buckley, S. M. Mansour Haeryfar, Lisa Cameron, Ewa Cairns, Lillian Barra   +6 more
wiley   +1 more source

GATA3 amplification is associated with high grade disease in non-invasive urothelial bladder cancer but unrelated to patient prognosis

BMC Urology
Purpose We aimed to assess the impact of GATA3 binding protein (GATA3) gene copy number alterations on tumor aggressiveness, patient prognosis, and GATA3 protein expression in a large urothelial bladder cancer cohort.
Henning Plage, Adrian Frericks, Sebastian Hofbauer, Kira Furlano, Sarah Weinberger, Florian Roßner, Simon Schallenberg, Sefer Elezkurtaj, Maximilian Lennartz, Andreas Marx, Henrik Samtleben, Margit Fisch, Michael Rink, Marcin Slojewski, Krystian Kaczmarek, Thorsten Ecke, Stefan Koch, Ronald Simon, Guido Sauter, Henrik Zecha, Joachim Weischenfeldt, Tobias Klatte, Sarah Minner, David Horst, Thorsten Schlomm, Martina Kluth   +25 more
doaj   +1 more source

GATA3 Immunohistochemical Expression in Salivary Gland Neoplasms [PDF]

Head and Neck Pathology, 2013
GATA3 is a zinc finger transcription factor that regulates the normal development of many tissues and cell types. Recent studies have shown that immunohistochemical nuclear staining for GATA3 among tumors is highly restricted to carcinomas of breast and urothelial origin; however salivary gland tumors have not been tested.
Lauren E, Schwartz, Shahnaz, Begum, William H, Westra, Justin A, Bishop   +3 more
openaire   +2 more sources

The synergistic impact of granulocytic myeloid‐derived suppressor cells and innate lymphoid cells in systemic sclerosis

Arthritis &Rheumatology, Accepted Article.
Objective Systemic sclerosis (SSc) is a chronic autoimmune disorder characterized by immune dysregulation and fibrosis, with myeloid‐derived suppressor cells (MDSCs) emerging as important regulators of immune responses. However, the role of MDSCs in SSc‐associated fibrosis and their interactions with other immune cell populations remain poorly ...
Stefanie Weber, Mario R. Angeli, Hashem Mohammadian, Hannah Labinsky, Maria Gabriella Raimondo, Richard Demmler, Yuko Ariza, Thomas Wohlfahrt, Markus Luber, Yi‐Nan Li, Jörg H.W. Distler, Tobias Bäuerle, Georg Schett, Simon Rauber, Andreas Ramming, Alina M. Ramming   +15 more
wiley   +1 more source

NFAT1 inhibits GATA3-induced CRTh2 promoter activation.

, 2018
(A) GATA3, but not NFAT1, over-expression in Jurkat T cells increased transcriptional activity of CRTh2-pro/Luc. When GATA3 (G) and NFAT1 (N) were co-expressed this led to inhibition of GATA3-mediated activity.
Courtney Davidson (5478641), Nami Shrestha Palikhe (837147), Lauren A. Solomon (370382), Emily MacLean Scott (5478635), Jessica Storie (5478638), Lisa Cameron (636941)   +5 more
core   +1 more source

Gata3 Silencing Is Involved in Neuronal Differentiation and Its Abnormal Expression Impedes Neural Activity in Adult Retinal Neurocytes

, 2022
GATA binding protein 3 (Gata3), a zinc-finger transcription factor, plays an important role in neural development. However, its expression and bioactivity in the retina remain unclear.
Shuilian Chen, Xuan Liu, Jiejie Zhuang, Xi Chen, Anqi He, Zihua Jiang, Pei Chen, Keming Yu, Qian Luo, Jin Qiu, Ying Yang, Jing Zhuang, Yihui Wu, Qiyun Wang, Yan Li   +14 more
core   +1 more source