Results 41 to 50 of about 6,168 (196)

GATA3-ext cell sensitivity is due to on-target inhibition of G9A/GLP.

, 2016
(A-G) Dose response curves (DRC) and colony formation assay (CFA) in reduced supplement-containing medium. MCF10A control and cells expressing GATA3-ext were treated with the indicated concentrations of HMT inhibitors (A-F) or structurally related ...
Barbara Mair (3097941), Claudia Kerzendorfer (3097944), Vasiliki Theodorou (3097932), Sebastian M. B. Nijman (184825), Markus K. Muellner (256051), Tomasz Konopka (119797), Sejla Salic (3097947), Katia Sleiman (3097935), Violeta Serra (3097938)   +8 more
core   +1 more source

Supplementary Data and Methods from The KMT1A-GATA3-STAT3 Circuit Is a Novel Self-Renewal Signaling of Human Bladder Cancer Stem Cells

, 2017
Supplemental Materials show that KMT1A was highly expressed in BCSCs compared with either BCNSCs or normal bladder tissue, and positively regulated the self-renewal and tumorigenicity of human BCSCs via KMT1A-GATA3-STAT3 circuit.
Zhao Yang (358244), Aihua Deng (131888), Yun Zhang (131894), Luyun He (11566790), Kaisu Lin (15010253), Yong Liang (131898), Chong Li (120471), Tingyi Wen (10249)   +7 more
core   +1 more source

GATA3 Positively Correlates with BCL2 Expression in Indolent and Aggressive Histological Types of Cutaneous Basal Cell Carcinoma [PDF]

Türk Patoloji Dergisi
Objective: Some histological basal cell carcinoma (BCC) types demonstrate more aggressive behavior than others. They are known as high-risk BCC and are more challenging in therapy, contrary to indolent (low-risk) BCC types.
Fatma Alzahraa Abdelsalam ELKHAMISY, Ahmed Naeem EESA, Marwa Kamal SALLAM, Marwa Fathy HUSSEIN, Nadia Ahmed ABD EL-MOEZE   +4 more
doaj   +1 more source

p300‐Mediated H3K18 Lactylation Drives Radiation‐Induced Pulmonary Fibrosis via VIRMA‐Dependent m6A Modification of GATA3

Advanced Science, EarlyView.
Radiation triggers glycolytic reprogramming in alveolar epithelial type II cells, causing pathological lactate accumulation. This metabolic stress drives p300‐mediated H3K18 lactylation at the VIRMA promoter, activating transcription. Elevated VIRMA enriches m6A on GATA3 mRNA, which YTHDF1 stabilizes, ultimately driving epithelial–mesenchymal ...
Junxuan Yi, Mingwei Wang, Duo Yu, Mingqi Zhao, Xinyan Wang, Shiqi Li, Xiaowen Han, Wei Wei, Shunzi Jin   +8 more
wiley   +1 more source

Juvenile idiopathic arthritis associated with a mutation in GATA3 [PDF]

Arthritis Research & Therapy, 2019
GATA3 is a transcription factor that is important during development and plays a role in differentiation and activity of immune cells, particularly T cells. Abnormal T cell function is found in autoimmune arthritis. We present the first known case of autoimmune arthritis associated with a novel GATA3 mutation.Whole exome sequencing of the proband was ...
Anna E. Patrick, Wei Wang, Elly Brokamp, Thomas Brent Graham, Thomas M. Aune, Jessica B. Duis   +5 more
openaire   +4 more sources

Table_1_Divergent lncRNA GATA3-AS1 Regulates GATA3 Transcription in T-Helper 2 Cells.DOCX

, 2018
Long non-coding RNAs (lncRNAs) possess a diverse array of regulatory functions including activation and silencing of gene transcription, regulation of splicing, and coordinating epigenetic modifications.
Nathaniel Chapman (5903219), Laura C. Kim (5903216), Thomas M. Aune (237367), Charles F. Spurlock (5903222), Guzel Shaginurova (5903213), Hunter R. Gibbons (5903210)   +5 more
core   +1 more source

Phase Separation of SF3B1 Serves as a Critical Post‐Transcriptional Regulator During Early Mouse Embryogenesis

Advanced Science, EarlyView.
Phase separation of SF3B1 acts as a key regulatory mechanism for dynamic alternative splicing throughout early mouse embryogenesis. Its absence triggers extensive splicing errors, which induce persistent DNA damage, defective cell cycle progression, and failed cell lineage commitment, and ultimately hinder the normal growth and development of ...
Kang Zhao, Ting‐Yu Han, Yan‐Li Cheng, Yi‐Dan Zhang, Yu‐Wei Zhang, JinJian Guo, ShaoJun Zhang, WenZe Huang, Jing Zhang, Pei‐Yu Liao, Ying Xin, ChuanChen Chu, Qing‐Yuan Sun, ZhiZhen Liu, Xiang‐Hong Ou, Jun Xie   +15 more
wiley   +1 more source

GATA3 Expression in Breast Carcinoma: Associations with Clinicopathological Features

Indonesian Journal of Cancer
Background: Breast carcinoma is a heterogeneous disease, morphologically and molecularly. GATA binding protein 3 (GATA3) is an important marker in breast cancer origin. GATA3 expression and its prognostic value in breast carcinoma are inconsistent. Tumor
Ni Putu Sriwidyani, I Gusti Ayu Sri Mahendra Dewi, Naomi Juliana Sinaga, Ni Putu Wulan Tantri Dewi   +3 more
doaj   +1 more source

Targeting the YAP‐BST2 Axis Overcomes Intrinsic Anti‐PD‐1 Resistance in Metastatic Gastric Cancer

Advanced Science, EarlyView.
Concurrent YAP hyperactivation and Tp53 loss in Atp4b‐expressed parietal cell lineage drives gastric cancer initiation, multi‐organ metastasis, and intrinsic resistance to anti‐PD‐1 therapy. BST2 emerges as a direct YAP‐TEAD transcriptional target that engages PIRA2 on myeloid cells to establish an immunosuppressive microenvironment.
Weihong Zhang, Shilong Wang, Meng Wang, Ruixian Yu, Jingwu Yue, Lin Shao, Hui Zhang, Mengwen Zhu, Luyang Tian, Shuting Cheng, Weimin Qin, Yang Tang, Yi Han, Wenjia Wang, Liwei An, Yan Meng, Shi Jiao, Zhaocai Zhou   +17 more
wiley   +1 more source

Generation of a conditional Gata3 knockout allele.

, 2013
(A) The conditional Gata3 knockout allele was generated by crossing Gata3ex4GFP mice with FLPe germline deleter mice. The FLPe recombinase removed the Ires-GFP-neo cassette, thereby generating a Gata3 allele with loxP sites flanking exon 4 (Gata3flox ...
Sami Kamel Boualia (375352), Maxime Bouchard (216093), Abdallah Souabni (375354), Calli Merkel (375356), David Grote (375350), Xuan Chi (136651), Frank Costantini (58908), Thomas Carroll (375358)   +7 more
core   +1 more source