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Genomic Analysis of the Function of the Transcription Factor gata3 during Development of the Mammalian Inner Ear [PDF]
, 2009 We have studied the function of the zinc finger transcription factor gata3 in auditory system development by analysing temporal profiles of gene expression during differentiation of conditionally immortal cell lines derived to model specific auditory ...
Lawoko-Kerali, Grace +8 more
core +3 more sources
Transcriptomic analysis and novel insights into lens fibre cell differentiation regulated by Gata3 [PDF]
Open Biology, 2019 Gata3 is a DNA-binding transcription factor involved in cellular differentiation in a variety of tissues including inner ear, hair follicle, kidney, mammary gland and T-cells. In a previous study in 2009, Maeda et al. (Dev. Dyn.
Elena Martynova +4 more
doaj +1 more source
Indian Journal of Pathology and Microbiology, 2023 The synchronous occurrence of bilateral ovarian tumors and breast malignancy often raise the suspicion of a Krukenberg tumor or a hereditary breast and ovarian cancer syndrome, both of which are uncommon in clinical practice.
Pavithra Ayyanar +3 more
doaj +1 more source
Shift in GATA3 functions, and GATA3 mutations, control progression and clinical presentation in breast cancer [PDF]
Breast Cancer Research, 2014 Abstract Introduction GATA binding protein 3 (GATA3) is a regulator of mammary luminal cell differentiation, and an estrogen receptor (ER) associated marker in breast cancer. Tumor suppressor functions of GATA3 have been demonstrated primarily in basal-like breast cancers. Here, we focused on its function
Cohen, Helit +6 more
openaire +2 more sources
Case Reports in Oncology, 2022 The adrenal gland is a frequent site for metastasis, and the majority of the metastatic lesions of the adrenal gland normally originate from lung cancer, colon cancer, renal cell carcinoma, and melanoma.
Dingqi Sun +5 more
doaj +1 more source
Acta Pharmaceutica, 2022 Allergic asthma is an inflammatory disease of the airways which has a complex etiology. Punicalagin, a major polyphenol present in pomegranates, is reported to possess various biological properties including antioxidant and antiproliferative effects. The
Yu Li, Li Jianying
doaj +1 more source
Epigenetic deregulation of GATA3 in neuroblastoma is associated with increased GATA3 protein expression and with poor outcomes [PDF]
Scientific Reports, 2019 AbstractTo discover epigenetic changes that may underly neuroblastoma pathogenesis, we identified differentially methylated genes in neuroblastoma cells compared to neural crest cells, the presumptive precursors cells for neuroblastoma, by using genome-wide DNA methylation analysis.
Bader Almutairi +6 more
openaire +5 more sources
The Role of GATA3 in Adipogenesis & Insulin Resistance [PDF]
University of the Future: Re-Imagining Research and Higher Education, 2020 Background: Impaired adipogenesis plays an important role in the development of obesityassociated insulin resistance and type 2 diabetes. Adipose tissue inflammation is a crucial mediator of this process. In hyperglycemia, immune system is activated partially through upregulation of GATA3, causing exacerbation of the inflammatory state associated with ...
Al-Jaber, Hend Sultan +2 more
openaire +2 more sources
Türk Patoloji Dergisi, 2021 Epithelial-myoepithelial carcinoma (EMC) is a rare, low-grade, malignant salivary neoplasm. Establishing an accurate cytological diagnosis is often challenging owing to its rarity, bland cytologic appearance and variable representation of cell ...
Parikshaa GUPTA +2 more
doaj +1 more source
Gata3 Is a Critical Regulator of Cochlear Wiring [PDF]
The Journal of Neuroscience, 2013 Spiral ganglion neurons (SGNs) play a key role in hearing by rapidly and faithfully transmitting signals from the cochlea to the brain. Identification of the transcriptional networks that ensure the proper specification and wiring of SGNs during development will lay the foundation for efforts to rewire a damaged cochlea.
Jessica M, Appler +5 more
openaire +2 more sources