Continued expression of GATA3 is necessary for cochlear neurosensory development. [PDF]
PLoS ONE, 2013 Hair cells of the developing mammalian inner ear are progressively defined through cell fate restriction. This process culminates in the expression of the bHLH transcription factor Atoh1, which is necessary for differentiation of hair cells, but not for ...
Jeremy S Duncan, Bernd Fritzsch
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GATA3 Expression Is a Poor Prognostic Factor in Soft Tissue Sarcomas. [PDF]
PLoS ONE, 2016 Recent studies have investigated the significance of GATA3 expression in patients with various malignant tumors. However, no previous studies have evaluated the clinicopathological importance of GATA3 expression in soft tissue sarcomas (STS) patients.We ...
Toshiaki Haraguchi +10 more
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Interaction of the pioneer transcription factor GATA3 with nucleosomes [PDF]
Nature Communications, 2020 Abstract During cellular reprogramming, the pioneer transcription factor GATA3 binds chromatin, and in a context-dependent manner directs local chromatin remodeling and enhancer formation. Here, we use high-resolution nucleosome mapping in human cells to explore the impact of the position of GATA motifs on the surface of nucleosomes ...
Hiroki Tanaka +7 more
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GATA3 expression in triple‐negative breast cancers [PDF]
Histopathology, 2017 AimsGATA‐binding protein 3 (GATA3) is a well‐studied transcription factor found to be essential in the development of luminal breast epithelium and has been identified in a variety of tumour types, including breast and urothelial carcinomas, making it a useful immunohistochemistry marker in the diagnosis of both primary and metastatic disease.Methods ...
David J Byrne +3 more
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The Diagnostic Value of Transcription Factors T-bet/GATA3 Ratio in Predicting Antibody-Mediated Rejection [PDF]
Clinical and Developmental Immunology, 2013 Background. Previous data showed that the predominance of intraglomerular T-bet or GATA3 is correlated with different mechanisms of rejection, suggesting that the ratio of T-bet/GATA3 might be used to distinguish antibody-mediated rejection (ABMR) and T ...
Xue Li +4 more
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Low expression of GATA3 promotes cell proliferation and metastasis in gastric cancer
Cancer Management and Research, 2017 Shuangqin Wei,1 Liang Zhong,2 Xiaoping Wang,1 Wenju Zhang3 1Department of Gastroenterology, Shanghai University of Medicine and Health Sciences Affiliated Zhoupu Hospital, 2Department of Gastroenterology, Huashan Hospital, Fudan University, 3School of ...
Wei S, Zhong L, Wang X, Zhang W
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BMC BiologyBackground Inadequate DNA damage repair promotes aberrant differentiation of mammary epithelial cells. Mammary luminal cell fate is mainly determined by a few transcription factors including GATA3.
Xuejie Wang +9 more
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GATA3 and APOBEC3B are prognostic markers in adrenocortical carcinoma and APOBEC3B is directly transcriptionally regulated by GATA3 [PDF]
Oncotarget, 2020 Recent evidence has implicated APOBEC3B (Apolipoprotein B mRNA editing enzyme catalytic subunit 3B) as a source of mutations in breast, bladder, cervical, lung, head, and neck cancers. However, the role of APOBEC3B in adrenocortical carcinoma (ACC) and the mechanisms through which its expression is regulated in cancer are not fully understood. Here, we
Gara, Sudheer Kumar +6 more
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Predictive value of GATA3 and Ki-67 expression in biopsy and transurethral resection specimens in patients with urothelial carcinoma of the urinary bladder [PDF]
Srpski Arhiv za Celokupno Lekarstvo, 2022 Introduction/Objective. Urothelial carcinoma is the most commonly diagnosed malignancy of urinary bladder in clinical and pathohistological practice where various prognostic factors play a significant role.
Šunjević Milena +2 more
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LncRNA GATA3-AS1 promotes the proliferation and migration of breast cancer cells and the mechanisms underlying its action [PDF]
Yixue xinzhi zazhi, 2022 Objective Long non-coding RNA (LncRNA) is closely related to the occurrence and development of various tumors. This study aimed to investigate the biological role and mechanism of LncRNA GATA3-AS1 in breast cancer progression.Methods The expression level
Qi JIANG, Yi-Qing XI, Lei WEI
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