Results 31 to 40 of about 6,168 (196)

The diagnostic utility of INSM1 and GATA3 in discriminating problematic medullary thyroid carcinoma, thyroid and parathyroid lesions

Polish Journal of Pathology, 2021
Discriminating thyroid and parathyroid lesions may sometimes pose a diagnostic difficulty. Medullary thyroid carcinomas (MTCs) display various cytologic and architectural features that resemble other thyroid and even rarely some parathyroid neoplasms ...
Sarah Adel Hakim, Nermine Mohamed Abd Raboh   +1 more
doaj   +1 more source

GATA3 mutation disrupts a functional network governed by estrogen receptor, FOXA1 and GATA3 [PDF]

, 2019
Abstract Estrogen receptors (ER) are part of the nuclear receptor superfamily of transcription factors and are activated by the steroid hormone 17β-estradiol. ER forms a regulatory network in conjunction with other transcription factors, such as FOXA1 and GATA3.
Takaku, Motoki, Grimm, Sara A., Kumar, Bony De, Bennett, Brian D., Wade, Paul A.   +4 more
openaire   +1 more source

GATA3 : a promising marker for metastatic breast carcinoma in serous effusion specimens [PDF]

, 2014
Background\ud \ud The utility of GATA3 as a marker for metastatic breast carcinoma in serous effusion specimens was investigated. \ud \ud Methods\ud \ud Cell block sections from 74 serous effusion specimens (32 ascitic, 2 pericardial and 40 pleural ...
Paul W. Shield, Shield, Paul W., David J. Papadimos, Walsh, Michael D., Michael D. Walsh, Papadimos, David J.   +5 more
core   +1 more source

Structure and Expression of the Human GATA3 Gene

Genomics, 1994
GATA3, a member of the GATA family that is abundantly expressed in the T-lymphocyte lineage, is thought to participate in T-cell receptor gene activation through binding to enhancers. To understand GATA3 gene regulation, we cloned the human gene and the 5' end of the mouse GATA3 gene.
M C, Labastie, D, Bories, C, Chabret, J M, Grégoire, S, Chrétien, P H, Roméo   +5 more
openaire   +2 more sources

Variation in phenotypes from a Bmp-Gata3 genetic pathway is modulated by Shh signaling.

PLoS Genetics, 2021
We sought to understand how perturbation of signaling pathways and their targets generates variable phenotypes. In humans, GATA3 associates with highly variable defects, such as HDR syndrome, microsomia and choanal atresia.
Mary E Swartz, C Ben Lovely, Johann K Eberhart   +2 more
doaj   +1 more source

Auditory and Vestibular Phenotypes Associated With GATA3 Mutation [PDF]

Otology & Neurotology, 2014
To report the auditory and vestibular phenotypes of patients with GATA3 mutation.Case series of 6 patients.Tertiary referral center.All patients had the classic triad of GATA3 deficiency: hypoparathyroidism, hearing loss, and renal dysplasia. Patients (29-60 yr old; mean age, 42.5 yr; 3 male and 3 female subjects) were confirmed to have heterozygous ...
Wade Wei-De, Chien, Jennifer W, Leiding, Amy P, Hsu, Christopher, Zalewski, Kelly, King, Steven M, Holland, Carmen, Brewer   +6 more
openaire   +2 more sources

Out of the Orphanage and into the Clinic — Therapeutic Targeting of GATA3 [PDF]

New England Journal of Medicine, 2015
In 1986, Mosmann et al. reported that T-cell lines can be divided into type 1 (Th1) and type 2 (Th2) on the basis of patterns of cytokine production.1 This classification of T cells according to their products subsequently expanded to include Th9, Th17, Th22, regulatory T cells, and follicular helper T cells.
Bruce S, Bochner, Robert P, Schleimer
openaire   +2 more sources

Hypoparathyroidism, deafness and renal dysplasia syndrome with bilateral cataract and bicornuate uterus caused by a de novo GATA3 mutation [PDF]

Exploration of Endocrine and Metabolic Diseases
Hypoparathyroidism, deafness and renal dysplasia (HDR) syndrome is a rare genetic disorder caused by haploinsufficiency of the GATA3 gene. A very limited number of cases have been reported in the literature to date.
Rajesh Chetiwal, Amit Kumar, Shweta Tanwar, Priyank Rastogi   +3 more
doaj   +1 more source

Immunohistochemical expression of GATA3 in urothelial carcinoma of urinary bladder

Zanco Journal of Medical Sciences
Background and objective: GATA3, an emerging immunohistochemical marker, is a zinc finger transcription factor that is expressed in normal urothelial epithelium and its corresponding neoplasms, and it has been recognized as a reliable urothelial related ...
Shadan Abdulkhaliq Jaf, Jalal Ali Jalal
doaj   +1 more source

GATA3 abnormalities and the phenotypic spectrum of HDR syndrome [PDF]

Journal of Medical Genetics, 2001
We report on GATA3 analysis and the phenotypic spectrum in nine Japanese families with the HDR syndrome ( h ypoparathyroidism, sensorineural d eafness, and r enal dysplasia) (MIM 146255).
K, Muroya, T, Hasegawa, Y, Ito, T, Nagai, H, Isotani, Y, Iwata, K, Yamamoto, S, Fujimoto, S, Seishu, Y, Fukushima, Y, Hasegawa, T, Ogata   +11 more
openaire   +2 more sources