Results 51 to 60 of about 6,168 (196)

Bcl11b, a novel GATA3-interacting protein, suppresses Th1 while limiting Th2 cell differentiation [PDF]

, 2018
GATA-binding protein 3 (GATA3) acts as the master transcription factor for type 2 T helper (Th2) cell differentiation and function. However, it is still elusive how GATA3 function is precisely regulated in Th2 cells.
Bing Sun, Gangqing Hu, Chao Zhong, Ming Zhao, Liu, P, Fang, D, Ryoji Yagi, Zhu, J, Kairong Cui, Keji Zhao, Cui, K, Oler, AJ, Suveena Sharma, Pentao Liu, Rama Krishna Gurram, Sun, B, Zhao, K, Hu, G, Gurram, RK, Zhong, C, Jinfang Zhu, Andrew J. Oler, Zhao, M, Yagi, R, Difeng Fang, Sharma, S   +25 more
core   +1 more source

GATA3 as a Prognostic Marker in Early‐Stage Classical Mycosis Fungoides: Association With Disease Progression and Survival Outcomes

Cancer Medicine
Background and Objective Classical mycosis fungoides (CMF), the most common form of primary cutaneous T‐cell lymphoma, shows marked heterogeneity in disease progression and prognosis, while reliable molecular prognostic markers remain scarce.
Pengfei Wen, Fan Li, Yao Xie, Wei Chen, Tingting Wang, Xiaoxue Zhuo, Lin Wang   +6 more
doaj   +1 more source

Decreased expression of the GATA3 gene is associated with poor prognosis in primary gastric adenocarcinoma. [PDF]

PLoS ONE, 2014
BACKGROUND: GATA binding protein 3 (GATA3) was recently proposed to function as a tumor suppressor gene in some types of human cancer. This study aims to investigate GATA3 expression and its prognostic significance in primary gastric adenocarcinoma ...
Rajiv Prasad Keshari, Wei Wang, Yu Zhang, Dan-dan Wang, Yuan-fang Li, Shu-qiang Yuan, Hai-bo Qiu, Chun-yu Huang, Yong-ming Chen, Jian-chuan Xia, Zhi-wei Zhou   +10 more
doaj   +1 more source

CHD8‐Dependent Chromatin Licensing Sustains Trophoblast Stem Cell Transcriptional Programs

Advanced Science, EarlyView.
In this study, Huang et al., identify chromatin remodeler CHD8 as an essential factor in TSC maintenance and placental development. CHD8‐dependent chromatin accessibility supports the occupancy of key trophoblast TFs and is coupled to KMT2A‐associated H3K4me3 deposition at TSC stem and cell cycle genes, providing a permissive chromatin environment for ...
Yuanyuan Huang, Zhenhua Hu, Jiali Liao, Lijun Huang, Jinyu Liu, Chen Tu, Yuchen Li, Lulu Xie, Shilei Bi, Xiaobo Fang, Jingsi Chen, Lili Du, Wei Sun, Haibin Wang, Shuang Zhang, Dunjin Chen, Zhaowei Tu   +16 more
wiley   +1 more source

Gata3 is necessary for maintenance of Ret expression.

, 2013
(A–F) Gata3 maintains Ret expression in the nephric duct at E11.5. (A) Whole mount in situ hybridization of control UGS with a Ret cRNA probe shows the smooth gradient of Ret expression along the entire length of the nephric duct.
Sami Kamel Boualia (375352), Maxime Bouchard (216093), Abdallah Souabni (375354), Calli Merkel (375356), David Grote (375350), Xuan Chi (136651), Frank Costantini (58908), Thomas Carroll (375358)   +7 more
core   +1 more source

Unilateral Ovarian Metastasis from an Occult Breast Primary Presenting as a Primary Ovarian Neoplasm: A Case Report [PDF]

Journal of Clinical and Diagnostic Research
Metastatic ovarian neoplasms may closely mimic primary ones, particularly when unilateral. Metastasis from breast carcinoma is recognised, but presentation as an isolated ovarian mass without an identifiable primary lesion is rare and diagnostically ...
Ankit Gupta, Neha Sharma, Anshul Singh
doaj   +1 more source

One‐Step Induction of Oogonia‐Like and Pro‐Spermatogonia‐Like Cells From Porcine Pluripotent Stem Cells

Advanced Science, EarlyView.
This study established a one‐step method inducing pro‐spermatogonia‐like (activating SOX17) and oogonia‐like (activating SOX17/TFAP2C) cells from porcine pgEpiSCs with a NANOS3‐tdTomato reporter. EGF activates the core PGC program and supports survival; BMP4 further induces NANOS3 and DDX4 expression; IWR1 enhances PGCLC efficiency by suppressing ...
Pengcheng He, Liang Zhong, Tianzhi Chen, Yaxuan Yan, Xinze Chen, Runbo Li, Yingjie Wang, Yadi Teng, Minglei Zhi, Meng Wang, Jinying Zhang, Fan Zhao, Dengfeng Gao, Suying Cao, Jianyong Han   +14 more
wiley   +1 more source

A novel frameshift variant of GATA3 (p.Ala17ProfsTer178) responsible for HDR syndrome in a Japanese family

Endocrine Journal
HDR syndrome is an autosomal dominant disorder characterized by hypoparathyroidism (H), deafness (D), and renal dysplasia (R) caused by genetic variants of the GATA3 gene.
Yutaka Hasegawa, Toshie Segawa, Ai Chida, Eriko Yoshida, Hirofumi Kinno, Hiraku Chiba, Tomoyasu Oda, Yoshihiko Takahashi, Koji Nata, Yasushi Ishigaki   +9 more
doaj   +1 more source

The Characteristics of Tumor Microenvironment by the Single Cell Profile in Endometrial Cancer of no Specific Molecular Profile (NSMP) Subtype

Advanced Science, EarlyView.
A subset of tumor‐associated macrophages (TAMs) characterized by SPP1 expression is discovered, which may remodel the tumor microenvironment by potentially promoting CD4+ T cell stress and maintaining epithelial cell stemness through SPP1‐CD44, thereby potentially contributing to the proliferation and migration of tumor cells, which has been verified ...
Xinhui Yuan, Zhengyao Zhai, Chuyu Jing, Wei Zhang, Wenjuan Tian, Yulan Ren   +5 more
wiley   +1 more source

Negative regulation of GATA3 on SLCO4C1 expression.

, 2013
(A) Overexpression of GATA3. (B and C) Knockdown of GATA3. (B) Time-dependent alteration of the GATA3 and SLCO4C1 mRNA expression levels. (C) Western blot analysis of GATA3 (left) and SLCO4C1 (right).
Yoichi Takeuchi (431933), Chitose Suzuki (431941), Hisato Shima (431939), Tomokazu Souma (431942), Yoshihisa Tomioka (431944), Sadayoshi Ito (431945), Daisuke Saigusa (431932), Yasutoshi Akiyama (431930), Daisuke Jinno (431938), Takaaki Abe (431946), Yasuaki Yamamoto (431935), Daiki Sugawara (431937), Ayako Ishida (431936), Takashi Moriguchi (431943), Takehiro Suzuki (299577), Koichi Kikuchi (431931), Eikan Mishima (431934), Takafumi Toyohara (431940)   +17 more
core   +1 more source